CABIN1 and CAMK4

Data Source:
BioGRID (enzymatic study)

		CABIN1	CAMK4
Description		calcineurin binding protein 1	calcium/calmodulin dependent protein kinase IV
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Aggresome	Fibrillar Center Nucleus Nucleoplasm Cytoplasm Extracellular Exosome Postsynapse Glutamatergic Synapse
	Molecular Function	Protein Phosphatase Inhibitor Activity Nucleosome Binding	Calmodulin-dependent Protein Kinase Activity Calmodulin Binding ATP Binding Calcium-dependent Protein Serine/threonine Kinase Activity
	Biological Process	DNA Replication-independent Nucleosome Assembly Cell Surface Receptor Signaling Pathway Negative Regulation Of Phosphoprotein Phosphatase Activity	Adaptive Immune Response Myeloid Dendritic Cell Cytokine Production Protein Phosphorylation Inflammatory Response Signal Transduction Long-term Memory Peptidyl-serine Phosphorylation Regulation Of T Cell Differentiation In Thymus Intracellular Signal Transduction Myeloid Dendritic Cell Differentiation Regulation Of Osteoclast Differentiation Positive Regulation Of Transcription, DNA-templated Protein Autophosphorylation
Pathways		Formation of Senescence-Associated Heterochromatin Foci (SAHF)	CaMK IV-mediated phosphorylation of CREB CaMK IV-mediated phosphorylation of CREB Transcriptional activation of mitochondrial biogenesis CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde Loss of phosphorylation of MECP2 at T308 Regulation of MECP2 expression and activity Negative regulation of NMDA receptor-mediated neuronal transmission
Drugs			K-00546 3-({[(3S)-3,4-dihydroxybutyl]oxy}amino)-1H,2'H-2,3'-biindol-2'-one
Diseases
GWAS		Acne (severe) ( 24927181) Amyotrophic lateral sclerosis ( 23624525) Coronary artery disease ( 29212778) S-phenylmercapturic acid levels in smokers ( 26959369) Urinary metabolite levels in chronic kidney disease ( 31959995)	Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406 29785011) Allergic rhinitis ( 30013184) Allergic sensitization ( 23817571) Allergy ( 27182965) Alzheimer's disease (cognitive decline) ( 23535033) Asthma ( 31959851 30929738 31619474) Asthma (childhood onset) ( 30929738) Asthma onset (childhood vs adult) ( 30929738) Autoimmune thyroid disease ( 32581359) Blood pressure ( 17903302) Lymphocyte counts ( 32888494) Lymphocyte percentage of white cells ( 32888494) Medication use (thyroid preparations) ( 31015401) Monocyte count ( 32888494) Periodontitis (PAL4Q3) ( 24024966) Self-reported allergy ( 23817569)
Interacting Genes		12 interacting genes: AMPH BORCS8-MEF2B CALM1 CAMK4 DNM1 GRM1 MEF2B MEF2D PPP3CA PPP3CB PPP3CC YWHAQ	10 interacting genes: CABIN1 CAMKK1 CAMKK2 CREBBP GAPDH HDAC4 NEDD4 NOS1 NOTCH1 RELA
Entrez ID		23523	814
HPRD ID		10369	07169
Ensembl ID		ENSG00000099991	ENSG00000152495
Uniprot IDs		A0A024R1E5 A0A087WWW8 Q9Y6J0	Q16566
PDB IDs		1N6J	2W4O
Enriched GO Terms of Interacting Partners?
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