CABIN1 and GRM1

Data Source:
BioGRID (pull down)

		CABIN1	GRM1
Description		calcineurin binding protein 1	glutamate metabotropic receptor 1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Aggresome	Nucleus Plasma Membrane Integral Component Of Plasma Membrane Dendrite G Protein-coupled Receptor Dimeric Complex G Protein-coupled Receptor Homodimeric Complex Schaffer Collateral - CA1 Synapse Postsynaptic Density Membrane Glutamatergic Synapse
	Molecular Function	Protein Phosphatase Inhibitor Activity Nucleosome Binding	Adenylate Cyclase Inhibiting G Protein-coupled Glutamate Receptor Activity G Protein-coupled Receptor Activity Protein Binding Glutamate Receptor Activity G Protein-coupled Neurotransmitter Receptor Activity Involved In Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration G Protein-coupled Receptor Activity Involved In Regulation Of Postsynaptic Membrane Potential Neurotransmitter Receptor Activity Involved In Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration
	Biological Process	DNA Replication-independent Nucleosome Assembly Cell Surface Receptor Signaling Pathway Negative Regulation Of Phosphoprotein Phosphatase Activity	Activation Of MAPKK Activity Activation Of MAPK Activity G Protein-coupled Receptor Signaling Pathway G Protein-coupled Glutamate Receptor Signaling Pathway Chemical Synaptic Transmission Locomotory Behavior Sensory Perception Of Pain Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G Protein-coupled Signaling Pathway Regulation Of Sensory Perception Of Pain Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Postsynaptic Membrane Potential Cellular Response To Electrical Stimulus L-glutamate Import Across Plasma Membrane Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration
Pathways		Formation of Senescence-Associated Heterochromatin Foci (SAHF)	G alpha (q) signalling events Class C/3 (Metabotropic glutamate/pheromone receptors) Neurexins and neuroligins Neurexins and neuroligins
Drugs			Glutamic acid (S)-alpha-methyl-4-carboxyphenylglycine
Diseases
GWAS		Acne (severe) ( 24927181) Amyotrophic lateral sclerosis ( 23624525) Coronary artery disease ( 29212778) S-phenylmercapturic acid levels in smokers ( 26959369) Urinary metabolite levels in chronic kidney disease ( 31959995)	Cerebral amyloid deposition (PET imaging) ( 26252872) Suicide ( 31476763) Waist circumference ( 29212154)
Interacting Genes		12 interacting genes: AMPH BORCS8-MEF2B CALM1 CAMK4 DNM1 GRM1 MEF2B MEF2D PPP3CA PPP3CB PPP3CC YWHAQ	40 interacting genes: ADORA1 BECN1 CABIN1 CASR CCND2 CCNE1 CD44 CDK4 CDK6 CDKN2B CDKN2C EFNB2 EPB41L2 EPHA2 ERBB2 FGFR4 GAPDH GPRASP1 GRK2 HOMER1 HOMER2 IGF1R ITPR1 KAT2A KDELR2 LATS2 MAP2K5 MYC NF2 OPRM1 OPTN PDGFRA PRKCA RAF1 RASSF1 STK11 TAMALIN TERT TTYH2 TUBB
Entrez ID		23523	2911
HPRD ID		10369	05129
Ensembl ID		ENSG00000099991	ENSG00000152822
Uniprot IDs		A0A024R1E5 A0A087WWW8 Q9Y6J0	Q13255 Q59HC2
PDB IDs		1N6J	3KS9 4OR2
Enriched GO Terms of Interacting Partners?
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