PPP3CB and SLC8A3

Data Source:
HPRD (in vivo)

		PPP3CB	SLC8A3
Description		protein phosphatase 3 catalytic subunit beta	solute carrier family 8 member A3
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Calcineurin Complex Z Disc T-tubule Glutamatergic Synapse	Mitochondrial Outer Membrane Endoplasmic Reticulum Membrane Microtubule Plasma Membrane Integral Component Of Plasma Membrane Postsynaptic Density Membrane Sarcoplasm Axon Dendrite Intrinsic Component Of Plasma Membrane Neuromuscular Junction Sarcolemma Neuronal Cell Body Dendritic Spine Perikaryon Axon Terminus Synapse Perinuclear Region Of Cytoplasm Postsynapse Integral Component Of Postsynaptic Membrane
	Molecular Function	Protein Serine/threonine Phosphatase Activity Calcium Ion Binding Protein Binding Calmodulin Binding Enzyme Binding Protein Phosphatase 2B Binding Calmodulin-dependent Protein Phosphatase Activity Protein Dimerization Activity Protein Serine Phosphatase Activity Protein Threonine Phosphatase Activity	Calcium:sodium Antiporter Activity Calmodulin Binding Cation:cation Antiporter Activity Metal Ion Binding Ion Antiporter Activity Involved In Regulation Of Postsynaptic Membrane Potential Calcium:cation Antiporter Activity Involved In Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration
	Biological Process	Negative Regulation Of T Cell Mediated Cytotoxicity Lymphangiogenesis Protein Phosphorylation Protein Dephosphorylation Signal Transduction Wnt Signaling Pathway, Calcium Modulating Pathway Heart Development Learning Memory Dephosphorylation Calcium-ion Regulated Exocytosis T Cell Differentiation Locomotion Involved In Locomotory Behavior Calcineurin-NFAT Signaling Cascade Response To Cytokine Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Fc-epsilon Receptor Signaling Pathway T Cell Proliferation T Cell Activation T Cell Homeostasis Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Synaptic Plasticity Axon Extension Regulation Of Insulin Secretion Calcineurin-mediated Signaling Regulation Of Synaptic Vesicle Endocytosis	Hematopoietic Progenitor Cell Differentiation Ion Transport Mitochondrial Calcium Ion Transmembrane Transport Cellular Calcium Ion Homeostasis Cell Communication Learning Or Memory Learning Memory Regulation Of Skeletal Muscle Contraction Telencephalon Development Metal Ion Transport Sodium Ion Transmembrane Transport Myelination Oligodendrocyte Differentiation Synapse Organization Mitochondrial Calcium Ion Homeostasis Long-term Synaptic Potentiation Calcium Ion Transmembrane Transport Cellular Response To CAMP Cellular Response To Hypoxia Negative Regulation Of Protein Serine/threonine Kinase Activity Calcium Ion Import Across Plasma Membrane Modulation Of Excitatory Postsynaptic Potential Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration Regulation Of Cardiac Conduction Calcium Ion Export Across Plasma Membrane
Pathways		DARPP-32 events Calcineurin activates NFAT Calcineurin activates NFAT FCERI mediated Ca+2 mobilization Ca2+ pathway CLEC7A (Dectin-1) induces NFAT activation ROBO receptors bind AKAP5	Reduction of cytosolic Ca++ levels Sodium/Calcium exchangers Ion homeostasis Mitochondrial calcium ion transport
Drugs
Diseases
GWAS			Bipolar disorder ( 31043756) Corneal curvature ( 22969067) Cystic fibrosis severity ( 21602797) Daytime sleep phenotypes ( 27126917) Metabolite levels ( 23823483)
Interacting Genes		18 interacting genes: AATK CABIN1 EGFR FBXL17 IRAK1 IRF2 JUN LMTK2 MARCHF7 MYOZ2 MYOZ3 NFATC2 PTK7 ROR2 SLC8A1 SLC8A2 SLC8A3 SOCS3	5 interacting genes: GJA8 PPP3CB YWHAB YWHAE YWHAQ
Entrez ID		5532	6547
HPRD ID		00235	09723
Ensembl ID		ENSG00000107758	ENSG00000100678
Uniprot IDs		B7Z781 P16298	B3KU59 P57103
PDB IDs		4OR9 4ORA 4ORC
Enriched GO Terms of Interacting Partners?
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