RFK and RAB1A

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		RFK	RAB1A
Description		riboflavin kinase	RAB1A, member RAS oncogene family
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GO Annotations	Cellular Component	Cytoplasm Mitochondrion Cytosol	Golgi Membrane Early Endosome Endoplasmic Reticulum Golgi Apparatus Cytosol Endomembrane System Transport Vesicle Membrane Melanosome Extracellular Exosome
	Molecular Function	Protein Binding ATP Binding Riboflavin Kinase Activity Metal Ion Binding	GTPase Activity Protein Binding GTP Binding Cadherin Binding
	Biological Process	Riboflavin Metabolic Process Apoptotic Process Riboflavin Biosynthetic Process FMN Biosynthetic Process Phosphorylation Positive Regulation Of NAD(P)H Oxidase Activity Reactive Oxygen Species Metabolic Process	Autophagosome Assembly Intracellular Protein Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Endocytosis Autophagy Golgi Organization Vesicle-mediated Transport Cell Migration Virion Assembly Growth Hormone Secretion Melanosome Transport Interleukin-8 Production Substrate Adhesion-dependent Cell Spreading Defense Response To Bacterium Post-translational Protein Modification Vesicle Transport Along Microtubule COPII Vesicle Coating Cilium Assembly COPII-coated Vesicle Cargo Loading Establishment Of Endothelial Intestinal Barrier Positive Regulation Of Glycoprotein Metabolic Process Positive Regulation Of Ubiquitin Protein Ligase Activity
Pathways		Vitamin B2 (riboflavin) metabolism	Golgi Cisternae Pericentriolar Stack Reorganization Golgi Cisternae Pericentriolar Stack Reorganization COPII-mediated vesicle transport COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs
Drugs		Riboflavin Flavin mononucleotide
Diseases
GWAS		Metabolite levels ( 23823483) Multiple sclerosis (age of onset) ( 19010793)	High light scatter reticulocyte percentage of red cells ( 32888494) Reticulocyte count ( 32888494) Triglyceride levels ( 32154731)
Interacting Genes		3 interacting genes: CNTLN DNAJB9 RAB1A	28 interacting genes: ADCK1 CAPNS1 CDKN1A CHML CREB1 CSNK1D FSCN1 GOLGA2 GOLGA5 GORASP2 HIVEP1 MAPRE3 MICAL1 MICALL1 OCRL PSMD7 RABAC1 RABEP1 RABGGTA RABGGTB RABIF RFK RUSC2 SLC16A8 SYT5 TBC1D17 USO1 ZNF593
Entrez ID		55312	5861
HPRD ID		17969	01538
Ensembl ID		ENSG00000135002	ENSG00000138069
Uniprot IDs		B2RDZ2 Q969G6	B7Z8M7 P62820 Q5U0I6
PDB IDs		1NB0 1NB9 1P4M 1Q9S	2FOL 2WWX 3L0I 3SFV 3TKL 4FMB 4FMC 4FMD 4FME 4IRU 4JVS
Enriched GO Terms of Interacting Partners?
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