UBE2W and TOPORS

Data Source:
BioGRID (two hybrid)

		UBE2W	TOPORS
Description		ubiquitin conjugating enzyme E2 W	TOP1 binding arginine/serine rich protein, E3 ubiquitin ligase
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm	Ubiquitin Ligase Complex Spindle Pole Gamma-tubulin Complex Nucleus Nucleoplasm Centriole Cytoplasmic Dynein Complex PML Body Nuclear Speck Midbody Photoreceptor Connecting Cilium Ciliary Basal Body
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Ubiquitin Protein Ligase Binding Ubiquitin Conjugating Enzyme Activity	DNA Binding Antigen Binding Ubiquitin-protein Transferase Activity Protein Binding SUMO Transferase Activity DNA Topoisomerase Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Protein Polyubiquitination DNA Repair Protein Monoubiquitination Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K11-linked Ubiquitination Cellular Response To Misfolded Protein	Protein Polyubiquitination Transcription, DNA-templated Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Cellular Response To DNA Damage Stimulus Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Retina Layer Formation Protein Sumoylation Protein Localization To Nucleus Photoreceptor Cell Outer Segment Organization Regulation Of Cell Population Proliferation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Transcription, DNA-templated Retinal Rod Cell Development Retinal Cone Cell Development Positive Regulation Of Ubiquitin-protein Transferase Activity Maintenance Of Protein Location In Nucleus Protein K48-linked Ubiquitination
Pathways		Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation	SUMOylation of transcription cofactors SUMOylation of SUMOylation proteins SUMOylation of immune response proteins
Drugs
Diseases			Retinitis pigmentosa (RP)
GWAS		Malaria ( 31844061) Manganese levels ( 26025379) Urate levels in obese individuals ( 25811787)	Early spontaneous preterm birth ( 31194736) Immune response to smallpox vaccine (IL-6) ( 22610502) Metabolite levels ( 23823483)
Interacting Genes		78 interacting genes: AKR1C3 AMFR BARD1 BFAR BIRC2 BIRC8 BRCA1 CADPS2 CBL CHFR CNOT4 DNMT3B DTX3 DTX3L DZIP3 EED FANCL LRSAM1 MAP3K1 MAPT MARCHF3 MARCHF5 MGRN1 MIB1 MID1 MKRN1 MKRN3 MUL1 PJA2 POLR2C PSTPIP1 RFWD3 RMND5B RNF10 RNF103 RNF111 RNF114 RNF115 RNF123 RNF125 RNF138 RNF14 RNF150 RNF152 RNF165 RNF166 RNF167 RNF183 RNF185 RNF2 RNF26 RNF31 RNF4 RNF5 RNF8 ROPN1 SNCA STUB1 TOPORS TRIM17 TRIM2 TRIM21 TRIM23 TRIM27 TRIM31 TRIM35 TRIM39 TRIM5 TRIM59 TRIM8 UBA1 UBOX5 UFM1 UHRF2 USHBP1 XIAP ZNRF1 ZNRF4	28 interacting genes: CASP8 CREBBP EPM2A H2AX HABP4 MTDH NKX3-1 SATB1 SERBP1 SIN3A SNIP1 SPOP SUMO1 SUMO2 TOP1 TP53 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2I UBE2J1 UBE2L6 UBE2N UBE2W XRCC1
Entrez ID		55284	10210
HPRD ID		07724	11642
Ensembl ID		ENSG00000104343	ENSG00000197579
Uniprot IDs		Q96B02 Q96FI0 X6REH9	Q9NS56
PDB IDs		2A7L 2MT6
Enriched GO Terms of Interacting Partners?
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