TOPORS and HABP4

Data Source:
HPRD (two hybrid)

		TOPORS	HABP4
Description		TOP1 binding arginine/serine rich protein, E3 ubiquitin ligase	hyaluronan binding protein 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Spindle Pole Gamma-tubulin Complex Nucleus Nucleoplasm Centriole Cytoplasmic Dynein Complex PML Body Nuclear Speck Midbody Photoreceptor Connecting Cilium Ciliary Basal Body	Extracellular Region Nucleus Nucleoplasm Nucleolus Cytoplasm Golgi Apparatus Cytosol Cytoplasmic Stress Granule Cajal Body Sarcoplasm Nuclear Speck Sarcomere Gemini Of Coiled Bodies
	Molecular Function	DNA Binding Antigen Binding Ubiquitin-protein Transferase Activity Protein Binding SUMO Transferase Activity DNA Topoisomerase Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	RNA Binding Protein Binding SUMO Binding
	Biological Process	Protein Polyubiquitination Transcription, DNA-templated Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Cellular Response To DNA Damage Stimulus Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Retina Layer Formation Protein Sumoylation Protein Localization To Nucleus Photoreceptor Cell Outer Segment Organization Regulation Of Cell Population Proliferation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Transcription, DNA-templated Retinal Rod Cell Development Retinal Cone Cell Development Positive Regulation Of Ubiquitin-protein Transferase Activity Maintenance Of Protein Location In Nucleus Protein K48-linked Ubiquitination	Platelet Degranulation MRNA Processing RNA Splicing PML Body Organization Positive Regulation Of RNA Splicing Negative Regulation Of DNA Binding Positive Regulation Of Translational Initiation Cellular Response To Mechanical Stimulus
Pathways		SUMOylation of transcription cofactors SUMOylation of SUMOylation proteins SUMOylation of immune response proteins	Platelet degranulation
Drugs			Hyaluronic acid
Diseases		Retinitis pigmentosa (RP)
GWAS		Early spontaneous preterm birth ( 31194736) Immune response to smallpox vaccine (IL-6) ( 22610502) Metabolite levels ( 23823483)	Height ( 25282103 31562340) Household income (MTAG) ( 31844048)
Interacting Genes		28 interacting genes: CASP8 CREBBP EPM2A H2AX HABP4 MTDH NKX3-1 SATB1 SERBP1 SIN3A SNIP1 SPOP SUMO1 SUMO2 TOP1 TP53 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2I UBE2J1 UBE2L6 UBE2N UBE2W XRCC1	25 interacting genes: C1QBP CHD3 CRK DAXX ENO2 FRA10AC1 HMGXB4 KAT5 PIAS3 PPP1R15A PRKCA PRKCB PRKCD PRKCG PRKCQ PRKCZ PRMT1 RACK1 SRSF9 SYNCRIP TOPORS TP53 UBE2I VIM YBX1
Entrez ID		10210	22927
HPRD ID		11642	13628
Ensembl ID		ENSG00000197579	ENSG00000130956
Uniprot IDs		Q9NS56	Q5JVS0
PDB IDs
Enriched GO Terms of Interacting Partners?
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