SMG8 and SMG1

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology)

		SMG8	SMG1
Description		SMG8 nonsense mediated mRNA decay factor	SMG1 nonsense mediated mRNA decay associated PI3K related kinase
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GO Annotations	Cellular Component	Cellular_component Cytosol	Nucleus Nucleoplasm Cytoplasm Cytosol TORC1 Complex TORC2 Complex
	Molecular Function	Protein Binding	RNA Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Telomeric DNA Binding Metal Ion Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Regulation Of Protein Kinase Activity	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay DNA Repair MRNA Export From Nucleus Negative Regulation Of Macroautophagy Peptidyl-serine Phosphorylation Regulation Of Telomere Maintenance TORC1 Signaling Protein Autophosphorylation Phosphatidylinositol Phosphorylation Regulation Of Response To DNA Damage Stimulus
Pathways		Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS			Health literacy ( 31250787) Heel bone mineral density ( 30598549) Refractive error ( 32231278)
Interacting Genes		1 interacting genes: SMG1	9 interacting genes: CDH5 PRKCI SMAD9 SMG5 SMG8 SNAPIN UPF1 UPF2 UPF3A
Entrez ID		55181	23049
HPRD ID		08551	06123
Ensembl ID		ENSG00000167447	ENSG00000157106
Uniprot IDs		Q8ND04	Q96Q15
PDB IDs		6L54 6SYT 6Z3R	6L53 6L54 6SYT 6Z3R
Enriched GO Terms of Interacting Partners?
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