SMG1 and SNAPIN

Data Source:
BioGRID (two hybrid)

		SMG1	SNAPIN
Description		SMG1 nonsense mediated mRNA decay associated PI3K related kinase	SNAP associated protein
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol TORC1 Complex TORC2 Complex	Golgi Membrane Acrosomal Vesicle Manchette Lysosomal Membrane Synaptic Vesicle Secretory Granule Synaptic Vesicle Membrane BLOC-1 Complex Synapse Perinuclear Region Of Cytoplasm BORC Complex Axon Cytoplasm
	Molecular Function	RNA Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Telomeric DNA Binding Metal Ion Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity	SNARE Binding Protein Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay DNA Repair MRNA Export From Nucleus Negative Regulation Of Macroautophagy Peptidyl-serine Phosphorylation Regulation Of Telomere Maintenance TORC1 Signaling Protein Autophosphorylation Phosphatidylinositol Phosphorylation Regulation Of Response To DNA Damage Stimulus	Intracellular Protein Transport Lysosome Organization Lysosomal Lumen Acidification Neurotransmitter Secretion Anterograde Axonal Transport Retrograde Axonal Transport Endosome To Lysosome Transport Negative Regulation Of Neuron Projection Development Viral Process Synaptic Vesicle Exocytosis Synaptic Vesicle Maturation Neuron Projection Development Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Lysosome Localization Melanosome Organization Cellular Protein-containing Complex Localization Regulation Of Protein Binding Synaptic Vesicle Transport Anterograde Synaptic Vesicle Transport Protein Maturation Terminal Button Organization Autophagosome Maturation Late Endosome To Lysosome Transport Positive Regulation Of Late Endosome To Lysosome Transport Regulation Of Synaptic Vesicle Exocytosis
Pathways		Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	Golgi Associated Vesicle Biogenesis
Drugs
Diseases
GWAS		Health literacy ( 31250787) Heel bone mineral density ( 30598549) Refractive error ( 32231278)
Interacting Genes		9 interacting genes: CDH5 PRKCI SMAD9 SMG5 SMG8 SNAPIN UPF1 UPF2 UPF3A	103 interacting genes: ABI2 ACTN2 ATG14 ATP1A1 BANP BFSP1 BFSP2 BIN1 BLOC1S1 BLOC1S2 BLOC1S4 BLOC1S5 BLOC1S6 BNIPL C20orf202 CCDC102B CDC42BPA CEP170 CMYA5 CSNK1D DDR1 DENND1C DES DNM2 DOCK9 DST DTNBP1 DYSF EBAG9 EEF1G ELP1 ENO3 ENTHD1 EXOC1 EXOC7 FAM114A1 FSD2 GPRASP1 HAP1 IKBIP IMMT INSYN1 KANK2 KAT5 KAT7 KIF5C KPNB1 KRT10 KRT15 KRT16 KRT17 KRT19 KRT20 KRT24 KRT26 KRT27 LAMA2 LAMC1 LMNB1 LRP12 MACF1 MAPK14 MET MTNR1A MYH14 MYH3 MYH7 NECAB2 NEDD9 NME7 NUP62CL PCYT1A PLAC9 PLEC PRKACA RABEP1 RABGEF1 RETREG1 RGS7 RNF13 SHBG SKA1 SMAD2 SMG1 SNAP23 SNAP25 SPAG5 SPP1 SPTB SPTBN1 ST7 TFIP11 TOMM70 TPM1 TPM2 TPM3 TPM4 TRIM63 TRPV1 TSG101 WASHC3 YWHAE YWHAZ
Entrez ID		23049	23557
HPRD ID		06123	06111
Ensembl ID		ENSG00000157106	ENSG00000143553
Uniprot IDs		Q96Q15	O95295
PDB IDs		6L53 6L54 6SYT 6Z3R
Enriched GO Terms of Interacting Partners?
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