SMG1 and UPF3A

Data Source:
HPRD (in vivo)

		SMG1	UPF3A
Description		SMG1 nonsense mediated mRNA decay associated PI3K related kinase	UPF3A regulator of nonsense mediated mRNA decay
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol TORC1 Complex TORC2 Complex	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Exon-exon Junction Complex Intracellular Membrane-bounded Organelle
	Molecular Function	RNA Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Telomeric DNA Binding Metal Ion Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity	RNA Binding Protein Binding Structural Constituent Of Nuclear Pore Telomeric DNA Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay DNA Repair MRNA Export From Nucleus Negative Regulation Of Macroautophagy Peptidyl-serine Phosphorylation Regulation Of Telomere Maintenance TORC1 Signaling Protein Autophosphorylation Phosphatidylinositol Phosphorylation Regulation Of Response To DNA Damage Stimulus	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Nucleocytoplasmic Transport Positive Regulation Of Translation MRNA Transport
Pathways		Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	Regulation of expression of SLITs and ROBOs Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS		Health literacy ( 31250787) Heel bone mineral density ( 30598549) Refractive error ( 32231278)	Height ( 31562340) Nodular sclerosis Hodgkin lymphoma ( 29196614) Pulse pressure ( 30578418)
Interacting Genes		9 interacting genes: CDH5 PRKCI SMAD9 SMG5 SMG8 SNAPIN UPF1 UPF2 UPF3A	9 interacting genes: ALYREF APP GSK3B IFITM2 NXF1 PIGT RBM8A SMG1 UPF1
Entrez ID		23049	65110
HPRD ID		06123	09274
Ensembl ID		ENSG00000157106	ENSG00000169062
Uniprot IDs		Q96Q15	B3KUE7 Q9H1J1
PDB IDs		6L53 6L54 6SYT 6Z3R	2L08
Enriched GO Terms of Interacting Partners?
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