FAM118A and ZNF451

Data Source:
BioGRID (two hybrid)

		FAM118A	ZNF451
Description		family with sequence similarity 118 member A	zinc finger protein 451
Image		No pdb structure
GO Annotations	Cellular Component	Integral Component Of Membrane	Nucleus PML Body
	Molecular Function	Protein Binding Identical Protein Binding	Transcription Corepressor Activity Protein Binding Metal Ion Binding SUMO Ligase Activity
	Biological Process		Regulation Of Gene Expression Protein Sumoylation Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Transcription Initiation From RNA Polymerase II Promoter Negative Regulation Of Histone H3-K9 Acetylation
Pathways
Drugs
Diseases
GWAS		Birth weight ( 31043758) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Chronotype ( 30696823) Dentures ( 31235808) Heel bone mineral density ( 30598549) Height ( 31562340) Number of decayed, missing and filled tooth surfaces or use of dentures ( 31235808) Peanut allergy (maternal genetic effects) ( 29489655) Periventricular white matter hyperintensities ( 32517579)
Interacting Genes		14 interacting genes: AIDA ATOX1 CDC37 DCDC2 FAM118B GLRX3 LNX1 MOB1A MOB3C RNF4 SDCBP UBE2I WDR4 ZNF451	33 interacting genes: AR CALCOCO2 CDC5L CDCA4 CPTP CREB1 CREBBP FAM118A FXR2 HTT JMJD6 KDM1A KLHL40 LZTR1 MID2 OPLAH PCBD1 PIAS1 PIAS2 PIK3R3 PML PRMT1 PRMT8 PRPF40A RAP1GDS1 RNF40 SNIP1 SUMO1 SUMO2 SUV39H1 UBC UBE2I ZNF467
Entrez ID		55007	26036
HPRD ID		07936	10332
Ensembl ID		ENSG00000100376	ENSG00000112200
Uniprot IDs		A0A024R4V3 Q9NWS6	B4DYS2 Q96JY2 Q9Y4E5
PDB IDs			5D2M
Enriched GO Terms of Interacting Partners?
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