ZNF451 and PRMT8

Data Source:
BioGRID (two hybrid)

		ZNF451	PRMT8
Description		zinc finger protein 451	protein arginine methyltransferase 8
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GO Annotations	Cellular Component	Nucleus PML Body	Nucleus Plasma Membrane Anchored Component Of The Cytoplasmic Side Of The Plasma Membrane
	Molecular Function	Transcription Corepressor Activity Protein Binding Metal Ion Binding SUMO Ligase Activity	Protein Binding Histone-arginine N-methyltransferase Activity S-adenosylmethionine-dependent Methyltransferase Activity Enzyme Binding Protein-arginine Omega-N Monomethyltransferase Activity Protein-arginine Omega-N Asymmetric Methyltransferase Activity Identical Protein Binding Protein Homodimerization Activity S-adenosyl-L-methionine Binding
	Biological Process	Regulation Of Gene Expression Protein Sumoylation Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Transcription Initiation From RNA Polymerase II Promoter Negative Regulation Of Histone H3-K9 Acetylation	Protein Methylation Histone Methylation Peptidyl-arginine Methylation Peptidyl-arginine Methylation, To Asymmetrical-dimethyl Arginine Histone Arginine Methylation Regulation Of Protein Binding Protein Homooligomerization
Pathways
Drugs
Diseases
GWAS			Cardiac Troponin-T levels ( 31014085) Erosive tooth wear (severe vs non-severe) ( 29898447) Erosive tooth wear (severe vs none or mild) ( 29898447) Gut microbiota (bacterial taxa) ( 27723756) HDL cholesterol ( 19060911)
Interacting Genes		33 interacting genes: AR CALCOCO2 CDC5L CDCA4 CPTP CREB1 CREBBP FAM118A FXR2 HTT JMJD6 KDM1A KLHL40 LZTR1 MID2 OPLAH PCBD1 PIAS1 PIAS2 PIK3R3 PML PRMT1 PRMT8 PRPF40A RAP1GDS1 RNF40 SNIP1 SUMO1 SUMO2 SUV39H1 UBC UBE2I ZNF467	22 interacting genes: CARM1 CEP162 COIL DCAF8 EWSR1 FBL FYN GPATCH2L H4C1 KRTAP6-3 OFCC1 PIK3R1 PLCG1 PPARA PRMT1 PRMT2 SERBP1 SYNCRIP TNPO2 UBL5 VHL ZNF451
Entrez ID		26036	56341
HPRD ID		10332	11029
Ensembl ID		ENSG00000112200	ENSG00000111218
Uniprot IDs		B4DYS2 Q96JY2 Q9Y4E5	Q59GT2 Q9NR22
PDB IDs		5D2M	4X41 5DST
Enriched GO Terms of Interacting Partners?
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