C1orf109 and MDM4

Data Source:
BioGRID (two hybrid)

		C1orf109	MDM4
Description		chromosome 1 open reading frame 109	MDM4 regulator of p53
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol	Nucleus Nucleoplasm
	Molecular Function	Protein Binding	DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding Zinc Ion Binding Enzyme Binding
	Biological Process		Negative Regulation Of Transcription By RNA Polymerase II Heart Valve Development Atrioventricular Valve Morphogenesis Endocardial Cushion Morphogenesis Ventricular Septum Development Atrial Septum Development Regulation Of Transcription By RNA Polymerase II DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Negative Regulation Of Cell Population Proliferation Protein Deubiquitination DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of Protein Catabolic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II Protein Stabilization Protein-containing Complex Assembly Negative Regulation Of Cell Cycle Arrest Cellular Response To Hypoxia Regulation Of Signal Transduction By P53 Class Mediator
Pathways			Oxidative Stress Induced Senescence Oncogene Induced Senescence Ub-specific processing proteases Regulation of TP53 Activity through Phosphorylation Regulation of TP53 Degradation Regulation of TP53 Activity through Methylation Stabilization of p53
Drugs
Diseases
GWAS		Axial length ( 24144296) Eyebrow thickness ( 26926045)	Breast cancer ( 23535733 27117709) Breast cancer (estrogen-receptor negative) ( 27117709 29058716) Breast cancer (estrogen-receptor negative, progesterone-receptor negative, and human epidermal growth factor-receptor negative) ( 24325915) Breast Cancer in BRCA1 mutation carriers ( 23544013) Cognitive performance ( 19734545) Diastolic blood pressure ( 27618452 30578418) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Fish- and plant-related diet ( 32066663) Glioma ( 28346443) Levodopa wearing off effect (time symptoms uncontrolled) in Parkinson's disease (response to zonisamide) ( 32355309) Non-glioblastoma glioma ( 28346443) Oily fish consumption ( 32066663) Pork consumption ( 32066663) Prostate cancer ( 23535732) Regular attendance at a religious group ( 29970889) Systolic blood pressure ( 27618452) Type 2 diabetes ( 32499647)
Interacting Genes		144 interacting genes: ABI2 ADD1 ANTKMT ATP23 AVPI1 BORCS6 C1orf94 C1QTNF2 C9orf24 CBY2 CCDC120 CCDC125 CCDC33 CCDC88B CCHCR1 CDCA4 CEP55 CINP CRX CSNK2A1 CT55 CTAG1A CTAG1B DISC1 ECM1 ECSIT FAM217B FAM86C1P FTO GET4 GIGYF1 GOLGA2 GOLGA6A GOLGA6L9 HESX1 HOOK2 HOXC8 IHO1 IKZF1 IKZF3 INKA1 KATNAL1 KIAA0753 KIFC3 KLF15 KRT13 KRT16 KRT18 KRT19 KRT24 KRT31 KRT35 KRT40 KRT75 KRT76 KRT80 KRTAP13-3 LDOC1 LMO2 LZTS2 MBD3L1 MDM4 MEI4 MEOX1 MEOX2 MIPOL1 MKRN2 MTFR1L MTUS2 NDUFB7 NECAB2 NFKBID NME4 NUP54 NUTM2F OOEP PAX5 PAX6 PAX7 PBX4 PDE4DIP PHC2 PLK4 PNMA1 POMC POU6F2 PPP1R12C PRDM6 PRMT5 PSMB4 PUDP REL RINT1 RNF20 RNF41 RPH3AL RUSC1 SAPCD2 SDCBP SERTAD1 SERTAD2 SLAIN1 SMARCD1 SOCS6 SORBS3 SPAG5 STMN3 STN1 STX11 TADA2A TASOR2 TCF12 TCF4 TEKT4 TEPSIN TFIP11 TLE5 TNNI2 TRAF1 TRIM27 TRIM42 TRIM54 TSGA10IP TTC12 TTC23 TTC23L UHMK1 USH1G USHBP1 VBP1 VGLL1 VPS52 YPEL3 ZBED1 ZBTB42 ZMAT1 ZMAT5 ZMYND12 ZNF17 ZNF20 ZNF398 ZNF420 ZNF688 ZSCAN9	63 interacting genes: AKT1 APP ARF1 ATM BECN1 C1orf109 CAPN7 CASP3 CBLC CD160 CD44 CDK1 CDK4 CDKN2A CDKN2B CHEK1 CHEK2 CSNK1A1 E2F1 EP300 EPHA2 FGFR4 GLIS2 HGF LATS2 LRSAM1 MAGEA1 MAP2K5 MDM2 MKRN3 MNAT1 NAA10 NF2 PELI1 PRKAA1 RAD54B RB1 RNF115 S100B SFN SMAD3 SMAD4 SMARCA2 TP53 TP63 TP73 TRIM46 TRIM55 UBC UBE2D1 UBE2D2 UBE2D3 USP7 VPS26C WDR5 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ ZKSCAN3 ZKSCAN4
Entrez ID		54955	4194
HPRD ID		07918	04082
Ensembl ID		ENSG00000116922	ENSG00000198625
Uniprot IDs		B4DRQ5 B7Z9X8 Q9NX04	A0A087WTR9 A0A087WUE3 A0A087WZ58 O15151 Q59FS6 Q68DC0
PDB IDs			2CR8 2MWY 2N06 2N0U 2N0W 2N14 2VJE 2VJF 2VYR 3DAB 3EQY 3FDO 3FE7 3FEA 3JZO 3JZP 3JZQ 3LBJ 3MQR 3U15 4RXZ 5MNJ 5UML 5VK1 6Q9Q 6Q9S 6Q9U 6Q9W 6Q9Y 7C3Q 7C3Y 7C44
Enriched GO Terms of Interacting Partners?
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