UBE2R2 and PRKN

Data Source:
BioGRID (pull down)

		UBE2R2	PRKN
Description		ubiquitin conjugating enzyme E2 R2	parkin RBR E3 ubiquitin protein ligase
Image
GO Annotations	Cellular Component	Cytosol	Ubiquitin Ligase Complex Nucleus Cytoplasm Mitochondrion Endoplasmic Reticulum Golgi Apparatus Cytosol Aggresome Nuclear Speck SCF Ubiquitin Ligase Complex Neuron Projection Perinuclear Region Of Cytoplasm Lewy Body Presynapse Mitochondrion-derived Vesicle Parkin-FBXW7-Cul1 Ubiquitin Ligase Complex
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Ubiquitin Conjugating Enzyme Activity	G Protein-coupled Receptor Binding Transcription Corepressor Activity Actin Binding Ubiquitin-protein Transferase Activity Protein Binding Beta-catenin Binding Zinc Ion Binding Tubulin Binding SH3 Domain Binding Enzyme Binding Kinase Binding Protein Kinase Binding PDZ Domain Binding Hsp70 Protein Binding Heat Shock Protein Binding Ubiquitin Conjugating Enzyme Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Histone Deacetylase Binding Ubiquitin Binding Phospholipase Binding Protein-containing Complex Binding Chaperone Binding Ubiquitin Protein Ligase Activity Cullin Family Protein Binding Ubiquitin-specific Protease Binding F-box Domain Binding
	Biological Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Protein Ubiquitination Protein K48-linked Ubiquitination	Negative Regulation Of Transcription By RNA Polymerase II Protein Polyubiquitination Mitochondrial Fission Autophagy Of Mitochondrion Mitophagy Negative Regulation Of Protein Phosphorylation Startle Response Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Response To Oxidative Stress Mitochondrion Organization Central Nervous System Development Learning Adult Locomotory Behavior Proteasomal Protein Catabolic Process Regulation Of Autophagy Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Mitochondrial Fusion Negative Regulation Of Mitochondrial Fusion Regulation Of Mitochondrion Organization Regulation Of Glucose Metabolic Process Free Ubiquitin Chain Polymerization Regulation Of Dopamine Secretion Macroautophagy Protein Ubiquitination Protein Deubiquitination Regulation Of Protein Ubiquitination Regulation Of Protein Stability Protein Destabilization Positive Regulation Of Protein Binding Negative Regulation Of Actin Filament Bundle Assembly Regulation Of Lipid Transport Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Glucokinase Activity Cellular Response To Unfolded Protein Response To Endoplasmic Reticulum Stress Synaptic Transmission, Glutamatergic Protein K29-linked Ubiquitination ERAD Pathway Regulation Of Dopamine Metabolic Process Norepinephrine Metabolic Process Dopamine Metabolic Process Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of DNA Binding Negative Regulation Of Neuron Apoptotic Process Cellular Protein Catabolic Process Cellular Protein Metabolic Process Protein K27-linked Ubiquitination Negative Regulation By Host Of Viral Genome Replication Positive Regulation Of Protein Catabolic Process Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of JNK Cascade Negative Regulation Of Insulin Secretion Protein Stabilization Positive Regulation Of Neurotransmitter Uptake Dopamine Uptake Involved In Synaptic Transmission Protein Autoubiquitination Regulation Of Mitochondrial Membrane Potential Zinc Ion Homeostasis Negative Regulation Of Cell Death Regulation Of Canonical Wnt Signaling Pathway Parkin-mediated Stimulation Of Mitophagy In Response To Mitochondrial Depolarization Neuron Cellular Homeostasis Protein K63-linked Ubiquitination Protein Localization To Mitochondrion Aggresome Assembly Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Cellular Response To Manganese Ion Protein K6-linked Ubiquitination Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Mitochondrial Fission Negative Regulation Of Release Of Cytochrome C From Mitochondria Cellular Response To Toxic Substance Positive Regulation Of Mitophagy In Response To Mitochondrial Depolarization Mitochondrion To Lysosome Transport Regulation Of Cellular Response To Oxidative Stress Negative Regulation Of Neuron Death Positive Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Negative Regulation Of Primary Amine Oxidase Activity Positive Regulation Of Protein Linear Polyubiquitination Regulation Of Synaptic Vesicle Transport Negative Regulation Of Oxidative Stress-induced Cell Death Regulation Of Protein Targeting To Mitochondrion Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Cellular Response To Dopamine Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Exosomal Secretion Positive Regulation Of Autophagy Of Mitochondrion Positive Regulation Of Dendrite Extension Negative Regulation Of Spontaneous Neurotransmitter Secretion Positive Regulation Of Retrograde Transport, Endosome To Golgi Negative Regulation Of Intralumenal Vesicle Formation Positive Regulation Of Protein Localization To Membrane Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation	PINK1-PRKN Mediated Mitophagy Josephin domain DUBs Aggrephagy Amyloid fiber formation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases			Parkinson's disease (PD)
GWAS		Bipolar disorder ( 20351715) Body mass index ( 25673413) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Estimated glomerular filtration rate ( 31015462) Health literacy ( 31250787) Immature fraction of reticulocytes ( 32888494) Mean corpuscular hemoglobin concentration ( 32888494) Refractive error ( 32231278)
Interacting Genes		27 interacting genes: APPBP2 ARHGDIA ARIH2 BTRC CBLC CSNK2A1 CSNK2A2 CTNNB1 CUL3 DTX3L DZIP3 FBXW5 GSC2 INF2 ITCH MAEA MDM2 MEOX1 MUL1 PNPLA2 PRKN RBX1 RNF113B RNF31 SDCBP UBA1 UBC	115 interacting genes: ADRM1 AIMP2 ARRB1 ARRB2 ATXN3 BAG5 BCL2L1 CASK CASP1 CASP8 CCNB1 CCND1 CDC34 CDK5 CDKN1A CHPF COMMD1 CRX CUL1 DLG1 DLX2 DNM1L DYRK1A EPS15 FAF1 FBP1 FBXO7 FBXW7 GPR37 GRIN2B HDAC6 HEXD HSD17B10 IKBKG MDM2 MEOX1 MEOX2 MFN1 MFN2 NDUFA4L2 NEK2 PAFAH1B2 PDCD2 PICK1 PKM PLK1 PRKAA2 PSMA1 PSMA7 PSMC1 PSMC2 PSMC5 PSMD4 PTPN5 PTTG1 RAB7A RAC1 RAD1 RAD23A RANBP2 RBCK1 REL RGS2 RGS3 RHOT2 SEPTIN4 SEPTIN5 SIM2 SNCA SNCAIP STUB1 SUMO1 SYT11 TCF4 TENT5C TOMM40 TOMM70 TP53 TRIP13 TUBA4A TUBB UBASH3A UBASH3B UBB UBC UBE2A UBE2B UBE2C UBE2D1 UBE2D2 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2G1 UBE2G2 UBE2H UBE2J1 UBE2J2 UBE2K UBE2L3 UBE2L6 UBE2M UBE2N UBE2O UBE2R2 UBE2S UBE2T UBE2V1 UBE2Z UCHL1 USP30 VDAC1 YWHAH ZNF746
Entrez ID		54926	5071
HPRD ID		15602	03967
Ensembl ID		ENSG00000107341	ENSG00000185345
Uniprot IDs		Q712K3	O60260 X5DR79
PDB IDs		6NYO	1IYF 2JMO 4BM9 4I1F 4I1H 5C1Z 5C23 5C9V 5N2W 5N38 5TR5 6GLC 6HUE 6N13
Enriched GO Terms of Interacting Partners?
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