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PRKN and FBXO7
Data Source:
BioGRID
(pull down)
PRKN
FBXO7
Description
parkin RBR E3 ubiquitin protein ligase
F-box protein 7
Image
GO Annotations
Cellular Component
Ubiquitin Ligase Complex
Nucleus
Cytoplasm
Mitochondrion
Endoplasmic Reticulum
Golgi Apparatus
Cytosol
Aggresome
Nuclear Speck
SCF Ubiquitin Ligase Complex
Neuron Projection
Perinuclear Region Of Cytoplasm
Lewy Body
Presynapse
Mitochondrion-derived Vesicle
Parkin-FBXW7-Cul1 Ubiquitin Ligase Complex
Ubiquitin Ligase Complex
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Cytosol
SCF Ubiquitin Ligase Complex
Protein-containing Complex
Glial Cytoplasmic Inclusion
Classical Lewy Body
Lewy Neurite
Lewy Body Core
Lewy Body Corona
Molecular Function
G Protein-coupled Receptor Binding
Transcription Corepressor Activity
Actin Binding
Ubiquitin-protein Transferase Activity
Protein Binding
Beta-catenin Binding
Zinc Ion Binding
Tubulin Binding
SH3 Domain Binding
Enzyme Binding
Kinase Binding
Protein Kinase Binding
PDZ Domain Binding
Hsp70 Protein Binding
Heat Shock Protein Binding
Ubiquitin Conjugating Enzyme Binding
Ubiquitin Protein Ligase Binding
Identical Protein Binding
Histone Deacetylase Binding
Ubiquitin Binding
Phospholipase Binding
Protein-containing Complex Binding
Chaperone Binding
Ubiquitin Protein Ligase Activity
Cullin Family Protein Binding
Ubiquitin-specific Protease Binding
F-box Domain Binding
Ubiquitin-protein Transferase Activity
Protein Binding
Protein Kinase Binding
Ubiquitin Protein Ligase Binding
Ubiquitin Binding
Protein Heterodimerization Activity
Ubiquitin Ligase-substrate Adaptor Activity
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Protein Polyubiquitination
Mitochondrial Fission
Autophagy Of Mitochondrion
Mitophagy
Negative Regulation Of Protein Phosphorylation
Startle Response
Ubiquitin-dependent Protein Catabolic Process
Protein Monoubiquitination
Response To Oxidative Stress
Mitochondrion Organization
Central Nervous System Development
Learning
Adult Locomotory Behavior
Proteasomal Protein Catabolic Process
Regulation Of Autophagy
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Positive Regulation Of Mitochondrial Fusion
Negative Regulation Of Mitochondrial Fusion
Regulation Of Mitochondrion Organization
Regulation Of Glucose Metabolic Process
Free Ubiquitin Chain Polymerization
Regulation Of Dopamine Secretion
Macroautophagy
Protein Ubiquitination
Protein Deubiquitination
Regulation Of Protein Ubiquitination
Regulation Of Protein Stability
Protein Destabilization
Positive Regulation Of Protein Binding
Negative Regulation Of Actin Filament Bundle Assembly
Regulation Of Lipid Transport
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Glucokinase Activity
Cellular Response To Unfolded Protein
Response To Endoplasmic Reticulum Stress
Synaptic Transmission, Glutamatergic
Protein K29-linked Ubiquitination
ERAD Pathway
Regulation Of Dopamine Metabolic Process
Norepinephrine Metabolic Process
Dopamine Metabolic Process
Regulation Of Apoptotic Process
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of DNA Binding
Negative Regulation Of Neuron Apoptotic Process
Cellular Protein Catabolic Process
Cellular Protein Metabolic Process
Protein K27-linked Ubiquitination
Negative Regulation By Host Of Viral Genome Replication
Positive Regulation Of Protein Catabolic Process
Positive Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of JNK Cascade
Negative Regulation Of Insulin Secretion
Protein Stabilization
Positive Regulation Of Neurotransmitter Uptake
Dopamine Uptake Involved In Synaptic Transmission
Protein Autoubiquitination
Regulation Of Mitochondrial Membrane Potential
Zinc Ion Homeostasis
Negative Regulation Of Cell Death
Regulation Of Canonical Wnt Signaling Pathway
Parkin-mediated Stimulation Of Mitophagy In Response To Mitochondrial Depolarization
Neuron Cellular Homeostasis
Protein K63-linked Ubiquitination
Protein Localization To Mitochondrion
Aggresome Assembly
Protein K48-linked Ubiquitination
Protein K11-linked Ubiquitination
Cellular Response To Manganese Ion
Protein K6-linked Ubiquitination
Negative Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Mitochondrial Fission
Negative Regulation Of Release Of Cytochrome C From Mitochondria
Cellular Response To Toxic Substance
Positive Regulation Of Mitophagy In Response To Mitochondrial Depolarization
Mitochondrion To Lysosome Transport
Regulation Of Cellular Response To Oxidative Stress
Negative Regulation Of Neuron Death
Positive Regulation Of Proteasomal Protein Catabolic Process
Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway
Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator
Negative Regulation Of Primary Amine Oxidase Activity
Positive Regulation Of Protein Linear Polyubiquitination
Regulation Of Synaptic Vesicle Transport
Negative Regulation Of Oxidative Stress-induced Cell Death
Regulation Of Protein Targeting To Mitochondrion
Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Cellular Response To Dopamine
Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway
Negative Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway
Negative Regulation Of Exosomal Secretion
Positive Regulation Of Autophagy Of Mitochondrion
Positive Regulation Of Dendrite Extension
Negative Regulation Of Spontaneous Neurotransmitter Secretion
Positive Regulation Of Retrograde Transport, Endosome To Golgi
Negative Regulation Of Intralumenal Vesicle Formation
Positive Regulation Of Protein Localization To Membrane
Regulation Of Reactive Oxygen Species Metabolic Process
Negative Regulation Of Reactive Oxygen Species Metabolic Process
Protein Polyubiquitination
Autophagy Of Mitochondrion
Ubiquitin-dependent Protein Catabolic Process
Protein Targeting To Mitochondrion
Regulation Of Neuron Projection Development
Protein Ubiquitination
Regulation Of Protein Stability
Regulation Of Locomotion
Post-translational Protein Modification
Negative Regulation Of Lymphocyte Differentiation
Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Negative Regulation Of Oxidative Stress-induced Neuron Death
Positive Regulation Of Autophagy Of Mitochondrion
Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways
PINK1-PRKN Mediated Mitophagy
Josephin domain DUBs
Aggrephagy
Amyloid fiber formation
Antigen processing: Ubiquitination & Proteasome degradation
Neddylation
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
Parkinson's disease (PD)
Parkinson's disease (PD)
GWAS
Blood protein levels (
29875488
)
Mean corpuscular hemoglobin (
29403010
32888494
27863252
)
Mean corpuscular volume (
29403010
32888494
27863252
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Red blood cell count (
32888494
27863252
)
Red blood cell traits (
23222517
)
Red cell distribution width (
32888494
27863252
)
Refractive error (
32231278
)
Interacting Genes
115 interacting genes:
ADRM1
AIMP2
ARRB1
ARRB2
ATXN3
BAG5
BCL2L1
CASK
CASP1
CASP8
CCNB1
CCND1
CDC34
CDK5
CDKN1A
CHPF
COMMD1
CRX
CUL1
DLG1
DLX2
DNM1L
DYRK1A
EPS15
FAF1
FBP1
FBXO7
FBXW7
GPR37
GRIN2B
HDAC6
HEXD
HSD17B10
IKBKG
MDM2
MEOX1
MEOX2
MFN1
MFN2
NDUFA4L2
NEK2
PAFAH1B2
PDCD2
PICK1
PKM
PLK1
PRKAA2
PSMA1
PSMA7
PSMC1
PSMC2
PSMC5
PSMD4
PTPN5
PTTG1
RAB7A
RAC1
RAD1
RAD23A
RANBP2
RBCK1
REL
RGS2
RGS3
RHOT2
SEPTIN4
SEPTIN5
SIM2
SNCA
SNCAIP
STUB1
SUMO1
SYT11
TCF4
TENT5C
TOMM40
TOMM70
TP53
TRIP13
TUBA4A
TUBB
UBASH3A
UBASH3B
UBB
UBC
UBE2A
UBE2B
UBE2C
UBE2D1
UBE2D2
UBE2D4
UBE2E1
UBE2E2
UBE2E3
UBE2G1
UBE2G2
UBE2H
UBE2J1
UBE2J2
UBE2K
UBE2L3
UBE2L6
UBE2M
UBE2N
UBE2O
UBE2R2
UBE2S
UBE2T
UBE2V1
UBE2Z
UCHL1
USP30
VDAC1
YWHAH
ZNF746
345 interacting genes:
AATF
ABCF3
ABL1
ACOT8
ACSL5
ACSM3
ACTC1
ACVR1
ACVR2B
AK8
AKAP14
AKIRIN2
AKT3
ALKBH3
AMOTL2
ANGPTL7
ANKRD36BP1
ANP32E
APEX1
APOBEC3C
APOBEC4
ASPH
ASPHD1
ATAT1
ATF5
ATP5F1C
BAG3
BCKDK
BIRC2
BLK
BUB1
BUB1B
C11orf16
C15orf48
C1orf105
C1orf115
C22orf31
C2orf88
CACYBP
CAMK1
CAPN5
CASQ2
CCBE1
CCDC186
CCDC60
CCDC88C
CCNE2
CDC34
CDK10
CDK14
CENPJ
CEP112
CFAP300
CHCHD2
CHCHD6
CHMP2B
CHMP3
CILK1
CIRBP
CKAP2
CLHC1
CLIP3
CMTR2
CNOT7
COLEC12
CPEB4
CSNK1E
CXCL12
CXCL9
DDRGK1
DDX10
DHRS2
DHX40
DNAH14
DNAJA3
DNAJB12
DNAJC30
DPY19L2P1
DRAP1
ELF4
EP400P1
EPHA3
EPHB2
EPHB3
EPHB4
ERBB2
ERICH2
FGF10
FGF13
FGFR1
FGFR2
FMOD
FUT8
FYTTD1
GADD45GIP1
GAPDH
GBP2
GEMIN2
GGA2
GLCE
GLIPR2
GLRX2
GMCL2
GNLY
GORAB
GPAM
GPKOW
GRK6
GSK3B
H1-0
H2AZ2
H3-3B
HADH
HMG20A
HMG20B
HMGB2
HMGCS2
HNRNPK
HPF1
IDH2
IFT88
IGKV1-5
IL4
IL7
ILKAP
INKA2
INPP5K
INTS7
IPO9
IRF3
JADE2
KCNAB1
KCTD14
KHDRBS3
KIAA1586
KIF12
KIFC3
KIRREL3-AS3
KLF4
KMO
KPNA5
LETMD1
LGALS3BP
LIMK1
LIMK2
LINC01483
LMNA
LRRC20
LRRC8E
LRRFIP1
MAK
MAP2K6
MAPK10
MAPK9
MAPRE2
MARK2
MARK3
MBD5
MBNL1
MCM2
MCM5
MDK
MED22
MED27
MEF2D
MEST
MIR1-1HG-AS1
MIS18BP1
MITF
MMP13
MMP8
MNDA
MOB3A
MOB3C
MPG
MPP3
MPZL1
MRM3
MRPL27
MRPS14
MTIF3
MTUS1
MYOG
NANS
NDE1
NFIA
NFIC
NKD2
NPHP1
NUDT16L1
NUMB
NVL
ODF2L
OLFML2A
OR14K1
ORC3
OSTF1
PABPC3
PACRG
PAFAH1B1
PAK6
PCBD2
PDCD7
PDE12
PDE4D
PDGFB
PGAP4
PHLDA1
PIEZO1
PIGY
PIM1
PIM2
PINK1
PLEKHA1
PNOC
PNRC2
POLDIP2
POLR2K
PPHLN1
PPP1CB
PPP1R17
PPP1R21
PRAME
PRICKLE2
PRKACB
PRKCA
PRKCB
PRKCG
PRKN
PRMT1
PRRC2B
PUF60
PUSL1
QKI
RBBP6
RBM23
RBM33
RCC1
REEP3
REEP4
RET
RGS1
RGS22
RNF121
RNF20
RORB
RPL14
RPL26
RPL36A
RPL37A
RPL3L
RPL6
RPS15A
RPS18
RPS19BP1
RPS2
RPS6KA3
RPS6KB1
RSL24D1
RWDD4
S100A13
S100A16
S100B
SAMHD1
SCARA5
SDCCAG8
SEC16B
SEC24C
SET
SFR1
SHMT1
SHMT2
SKP1
SLAIN1
SLC25A26
SLC35B3
SLC7A6OS
SMARCD1
SMOC2
SNAP25
SNRPA
SNX33
SPATA4
SPDYA
SPRY2
SRCIN1
SRPK3
SRSF10
SRSF7
SS18L2
STAT6
STYX
TAF9B
TARDBP
TBC1D3P2
TBPL1
TC2N
TCP10L3
TEAD4
TEC
TECR
TECRL
TENT5D
TEX29
TGIF2
THAP7
TLE3
TMED10
TMEM120A
TMEM237
TMOD2
TMPRSS5
TOMM20
TRAPPC12
TRIB3
TRIM44
TSBP1
TSLP
UBE2D1
UBE2D2
UBE2D3
UBE2E1
UBE2J2
UBE2M
UROD
USF1
USH1C
UXS1
UXT
VPS16
VRK3
WDR18
WDR24
XPO1
XRN1
YPEL5
ZBTB44
ZC2HC1C
ZFYVE21
ZKSCAN8
ZMYM5
ZNF462
ZNF574
ZNF684
ZNF688
Entrez ID
5071
25793
HPRD ID
03967
07292
Ensembl ID
ENSG00000185345
ENSG00000100225
Uniprot IDs
O60260
X5DR79
Q9Y3I1
PDB IDs
1IYF
2JMO
4BM9
4I1F
4I1H
5C1Z
5C23
5C9V
5N2W
5N38
5TR5
6GLC
6HUE
6N13
4L9C
4L9H
Enriched GO Terms of Interacting Partners
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