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SEMA4C and DLG3
Data Source:
HPRD
(two hybrid, in vitro)
SEMA4C
DLG3
Description
semaphorin 4C
discs large MAGUK scaffold protein 3
Image
GO Annotations
Cellular Component
Extracellular Space
Integral Component Of Plasma Membrane
Postsynaptic Density
Synaptic Vesicle Membrane
Postsynaptic Density Membrane
Extracellular Space
Cytosol
Plasma Membrane
Ionotropic Glutamate Receptor Complex
Basolateral Plasma Membrane
Cell Junction
Molecular Function
Protein Binding
Semaphorin Receptor Binding
Chemorepellent Activity
Protein Binding
Kinase Binding
Phosphatase Binding
Biological Process
Neural Crest Cell Migration
Neural Tube Closure
Axon Guidance
Cell Migration In Hindbrain
Cerebellum Development
Positive Regulation Of Cell Migration
Positive Regulation Of Stress-activated MAPK Cascade
Muscle Cell Differentiation
Negative Regulation Of Axon Extension Involved In Axon Guidance
Negative Chemotaxis
Semaphorin-plexin Signaling Pathway
MAPK Cascade
Negative Regulation Of Cell Population Proliferation
Embryo Development
Negative Regulation Of Phosphatase Activity
Receptor Clustering
Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity
Positive Regulation Of Protein Tyrosine Kinase Activity
Receptor Localization To Synapse
Cell-cell Adhesion
Regulation Of NMDA Receptor Activity
Pathways
Unblocking of NMDA receptors, glutamate binding and activation
Unblocking of NMDA receptors, glutamate binding and activation
Ras activation upon Ca2+ influx through NMDA receptor
NrCAM interactions
Activation of Ca-permeable Kainate Receptor
RAF/MAP kinase cascade
Neurexins and neuroligins
Neurexins and neuroligins
Synaptic adhesion-like molecules
Assembly and cell surface presentation of NMDA receptors
Negative regulation of NMDA receptor-mediated neuronal transmission
Long-term potentiation
Drugs
Diseases
Non-syndromic X-linked mental retardation
GWAS
Blood protein levels (
30072576
)
Mean platelet volume (
32888494
)
Interacting Genes
20 interacting genes:
CYSRT1
DLG1
DLG2
DLG3
DLG4
GIPC1
HSF2BP
KRT16
KRT27
KRT31
KRT34
KRT40
KRTAP6-3
NBPF19
NCDN
NOTCH2NLA
PNMA1
RCHY1
TRIM54
USHBP1
48 interacting genes:
ABCA1
ADGRL1
APC
ATP2B4
CACNG2
CALM1
CNKSR2
CRIPT
DHRS11
DLG1
DLG4
DLGAP1
DLGAP2
DLGAP3
DLGAP4
EIF4H
ERBB4
EXOC4
EXOC7
GDA
GLS2
GRIK2
GRIN1
GRIN2A
GRIN2B
GRIN2C
GUCY1A2
KCNA4
KCNJ12
KCNJ2
KDELR1
KHDRBS1
KIF1B
LIN7A
LRP2
MAPK12
NLGN1
NLGN2
NLGN3
OSBP2
PLEKHA2
PTK2B
RPS8
SCN4A
SCN5A
SEMA4C
SYNGAP1
VTN
Entrez ID
54910
1741
HPRD ID
07257
02177
Ensembl ID
ENSG00000168758
ENSG00000082458
Uniprot IDs
Q9C0C4
Q59FY1
Q92796
PDB IDs
6N5Z
1UM7
2FE5
2I1N
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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