SYTL2 and RAB27A

Data Source:
HPRD (in vitro, in vivo)

		SYTL2	RAB27A
Description		synaptotagmin like 2	RAB27A, member RAS oncogene family
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GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Membrane Extrinsic Component Of Plasma Membrane Melanosome Exocytic Vesicle	Photoreceptor Outer Segment Extracellular Region Lysosome Late Endosome Golgi Apparatus Cytosol Apical Plasma Membrane Secretory Granule Dendrite Secretory Granule Membrane Multivesicular Body Membrane Weibel-Palade Body Melanosome Membrane Specific Granule Lumen Melanosome Extracellular Exosome Exocytic Vesicle
	Molecular Function	Phosphatidylserine Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Phosphatase Binding Neurexin Family Protein Binding	GTPase Activity Protein Binding GTP Binding GDP Binding Protein Domain Specific Binding Myosin V Binding
	Biological Process	Intracellular Protein Transport Exocytosis Vesicle Docking Involved In Exocytosis Negative Regulation Of Phosphatase Activity Vesicle-mediated Transport	Protein Targeting Exocytosis Blood Coagulation Positive Regulation Of Gene Expression Antigen Processing And Presentation Melanocyte Differentiation Melanosome Localization Melanosome Transport Multivesicular Body Organization Neutrophil Degranulation Cytotoxic T Cell Degranulation Natural Killer Cell Degranulation Positive Regulation Of Exocytosis Synaptic Vesicle Transport Positive Regulation Of Phagocytosis Multivesicular Body Sorting Pathway Complement-dependent Cytotoxicity Positive Regulation Of Regulated Secretory Pathway Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Positive Regulation Of Constitutive Secretory Pathway Exosomal Secretion
Pathways			Insulin processing Neutrophil degranulation RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases			Other phagocyte defects, including the following eight diseases: Chediak-Higashi syndrome; Griscelli syndrome, type 1 (GS1); Griscelli syndrome, type 2 (GS2); Griscelli syndrome, type 3 (GS3); beta-actin deficiency; Neutrophil-specific granule deficiency; Myeloperoxidase deficiency; Glucose 6-phosphate dehydrogenase deficiency; Shwachman syndrome
GWAS		Pallidum volume ( 31530798) Refractive error ( 32231278)	Fractional exhaled nitric oxide levels ( 25431337) Glioma ( 30714141)
Interacting Genes		9 interacting genes: FBXO25 LNX1 MORN4 MTERF1 NRXN1 PPP1CA RAB27A RAB27B YIF1A	28 interacting genes: ADRB2 APP CEP126 COPS6 EEF1A1 ERG28 EXPH5 GDF9 GDI1 GZMB LRIF1 MLPH MYO5A MYRIP RABGGTB RBM48 RIMS1 RIMS2 RPH3A RPH3AL STX1A SYTL1 SYTL2 SYTL3 SYTL4 SYTL5 UNC13D ZBTB16
Entrez ID		54843	5873
HPRD ID		10260	04845
Ensembl ID		ENSG00000137501	ENSG00000069974
Uniprot IDs		A0A0U1RR07 Q9HCH5	A2RU94 P51159
PDB IDs		3BC1	6HUF
Enriched GO Terms of Interacting Partners?
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