TRPM4 and CCR9

Data Source:
BioGRID (two hybrid)

		TRPM4	CCR9
Description		transient receptor potential cation channel subfamily M member 4	C-C motif chemokine receptor 9
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GO Annotations	Cellular Component	Nucleoplasm Endoplasmic Reticulum Golgi Apparatus Cytosol Plasma Membrane Integral Component Of Plasma Membrane Sodium Channel Complex Neuronal Cell Body Spanning Component Of Plasma Membrane Spanning Component Of Membrane	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface
	Molecular Function	Calcium Activated Cation Channel Activity Cation Channel Activity Calcium Ion Binding Protein Binding Calmodulin Binding ATP Binding Ligand-gated Calcium Channel Activity	Chemokine Receptor Activity C-C Chemokine Receptor Activity C-C Chemokine Binding
	Biological Process	Adaptive Immune Response Dendritic Cell Chemotaxis Regulation Of T Cell Cytokine Production Positive Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Cell Population Proliferation Positive Regulation Of Heart Rate Protein Sumoylation Calcium-mediated Signaling Negative Regulation Of Bone Mineralization Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Vasoconstriction Positive Regulation Of Fat Cell Differentiation Negative Regulation Of Osteoblast Differentiation Positive Regulation Of Vasoconstriction Protein Homotetramerization Calcium Ion Transmembrane Transport Cellular Response To ATP Membrane Depolarization During AV Node Cell Action Potential Membrane Depolarization During Purkinje Myocyte Cell Action Potential Membrane Depolarization During Bundle Of His Cell Action Potential Regulation Of Heart Rate By Cardiac Conduction Positive Regulation Of Canonical Wnt Signaling Pathway Cation Transmembrane Transport Inorganic Cation Transmembrane Transport Sodium Ion Import Across Plasma Membrane Regulation Of Ventricular Cardiac Muscle Cell Action Potential Positive Regulation Of Atrial Cardiac Muscle Cell Action Potential Positive Regulation Of Adipose Tissue Development Positive Regulation Of Regulation Of Vascular Associated Smooth Muscle Cell Membrane Depolarization	CD8-positive, Gamma-delta Intraepithelial T Cell Differentiation Chemotaxis Immune Response Cellular Defense Response G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Viral Process Calcium-mediated Signaling Cell Chemotaxis Chemokine-mediated Signaling Pathway
Pathways		TRP channels	Chemokine receptors bind chemokines G alpha (i) signalling events
Drugs		Glyburide	Vercirnon
Diseases
GWAS			Celiac disease ( 20190752) Severe COVID-19 infection with respiratory failure (analysis I) ( 32558485) Severe COVID-19 infection with respiratory failure (analysis II) ( 32558485)
Interacting Genes		1 interacting genes: CCR9	19 interacting genes: ADGRG1 AIG1 CCL25 CD81 DGAT1 G6PC3 HLA-A KDELR1 NEU1 OSTC RHBDD2 SAP130 SCAMP4 SPNS1 TMC6 TRPM4 TSPAN7 TTYH1 YWHAE
Entrez ID		54795	10803
HPRD ID		09502	09200
Ensembl ID		ENSG00000130529	ENSG00000173585
Uniprot IDs		B4DIX5 Q8TD43	B2R734 P51686
PDB IDs		5WP6 6BQR 6BQV 6BWI	5LWE
Enriched GO Terms of Interacting Partners?
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