UBXN2B and PAX5

Data Source:
BioGRID (two hybrid)

		UBXN2B	PAX5
Description		UBX domain protein 2B	paired box 5
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Endoplasmic Reticulum Golgi Apparatus Cytosol Spindle Pole Centrosome	Chromatin Fibrillar Center Nucleoplasm Cytosol Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Binding Ubiquitin Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding
	Biological Process	Autophagosome Assembly Establishment Of Mitotic Spindle Orientation Golgi Organization Nuclear Envelope Reassembly Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Mitotic Centrosome Separation Membrane Fusion Negative Regulation Of Protein Localization To Centrosome	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Humoral Immune Response Multicellular Organism Development Spermatogenesis Aging Animal Organ Morphogenesis Lateral Ventricle Development Cerebral Cortex Development Adult Behavior Skeletal Muscle Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Embryonic Cranial Skeleton Morphogenesis Anatomical Structure Development Regulation Of B Cell Receptor Signaling Pathway Negative Regulation Of Histone H3-K9 Methylation
Pathways			RUNX1 regulates transcription of genes involved in BCR signaling
Drugs
Diseases			Lymphoplasmacytic lymphoma
GWAS		Gallstone disease ( 27094239) LDL cholesterol levels ( 30698716) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Loneliness ( 27629369) Low density lipoprotein cholesterol levels ( 29403010) Medication use (HMG CoA reductase inhibitors) ( 31015401) Narcolepsy with cataplexy ( 23496005) Systolic blood pressure response to hydrochlorothiazide in hypertension ( 27802415) Total cholesterol levels ( 29403010) Triglyceride levels ( 30698716) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716)	Adult body size ( 32376654) Alzheimer's disease ( 30636644) Composite immunoglobulin trait (IgA/IgM) ( 28628107) Coronary artery disease in type 1 diabetes ( 29695241) HIV-1 susceptibility ( 25786224) Intelligence ( 22449649) Major depressive disorder ( 27479909) Moderate to vigorous physical activity levels ( 29899525) Morning person ( 30696823) Obesity-related traits ( 22013104)
Interacting Genes		14 interacting genes: CRX FAM104A INCA1 MEOX1 MEOX2 NGLY1 PAX5 PAX6 PIN1 PPP1R11 UBXN6 VAT1L VCP XAF1	55 interacting genes: ACOT12 BCAS2 C1orf109 CCNC CDK3 CIB3 CKS1B CREBBP CSNK2A1 CXorf38 DAXX DTX2 EBF1 EP300 ETS1 FBLN1 GNG13 GRHL2 HGS HMBOX1 HMGB3 HOXC8 ID2 ID3 KLHL38 KPNA1 KPNA2 KRTAP10-8 KRTAP9-3 LARP4 LDLRAP1 LONRF1 MAPK1 MAPK9 MYB NEIL2 NFYC NGLY1 OSGIN1 PNMA5 RAD52 RB1 RNF144B RUNX1 SAE1 SEC14L4 STAC TBP TLE4 TLK2 UBE2I UBE3A UBXN2B UBXN7 ZMYM5
Entrez ID		137886	5079
HPRD ID		18973	01334
Ensembl ID		ENSG00000215114	ENSG00000196092
Uniprot IDs		E5RJ36 Q14CS0	C0KTE5 C0KTF5 E7EQT0 E7ERK2 E7ERW5 E7ES87 Q02548
PDB IDs			1K78 1MDM
Enriched GO Terms of Interacting Partners?
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