SGTB and BTC

Data Source:
BioGRID (two hybrid)

		SGTB	BTC
Description		small glutamine rich tetratricopeptide repeat co-chaperone beta	betacellulin
Image		No pdb structure
GO Annotations	Cellular Component	Membrane TRC Complex	Extracellular Region Extracellular Space Plasma Membrane Integral Component Of Membrane Clathrin-coated Vesicle Membrane
	Molecular Function	Protein Binding Molecular Adaptor Activity	Epidermal Growth Factor Receptor Binding Protein Binding Growth Factor Activity
	Biological Process	Posttranslational Protein Targeting To Endoplasmic Reticulum Membrane Ubiquitin-dependent ERAD Pathway Positive Regulation Of Chaperone-mediated Protein Folding	MAPK Cascade Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Positive Regulation Of Urine Volume ERBB2 Signaling Pathway Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Apoptotic Process Positive Regulation Of Cell Differentiation Positive Regulation Of Epidermal Growth Factor-activated Receptor Activity Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Fibroblast Proliferation Positive Regulation Of Cell Division Positive Regulation Of Protein Kinase B Signaling Membrane Organization Regulation Of Cell Motility
Pathways			Signaling by ERBB2 Signaling by ERBB4 SHC1 events in ERBB2 signaling SHC1 events in ERBB2 signaling PI3K events in ERBB4 signaling SHC1 events in ERBB4 signaling Nuclear signaling by ERBB4 PIP3 activates AKT signaling Signaling by EGFR GRB2 events in EGFR signaling GAB1 signalosome SHC1 events in EGFR signaling EGFR downregulation GRB2 events in ERBB2 signaling PI3K events in ERBB2 signaling EGFR interacts with phospholipase C-gamma Constitutive Signaling by Aberrant PI3K in Cancer Inhibition of Signaling by Overexpressed EGFR RAF/MAP kinase cascade ERBB2 Regulates Cell Motility PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling ERBB2 Activates PTK6 Signaling Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Downregulation of ERBB2 signaling Extra-nuclear estrogen signaling Estrogen-dependent nuclear events downstream of ESR-membrane signaling Signaling by ERBB2 KD Mutants Signaling by ERBB2 TMD/JMD mutants
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Breast size ( 27182965) Chronic obstructive pulmonary disease ( 30804561) Diverticular disease ( 30177863) Electroencephalogram traits ( 25387704) FEV1 ( 30804560) Lung function (FEV1/FVC) ( 30804560)
Interacting Genes		116 interacting genes: ABCG4 ADAT2 ADIPOQ AGR2 AGR3 ASPH BTC C1QA C1QL4 C1QTNF5 C1QTNF6 C5orf46 CALR CCL3L3 CD200R1 CD3D CD68 CD79B CD99L2 CDH15 CDSN CMPK1 COL10A1 COL1A2 COLQ COMP CREB3L3 CSH1 CSH2 CTAG1A CTAG1B CYB5R1 DEFA6 DEXI DMKN ECM1 EFEMP2 EMCN ERP29 ETNK1 EVA1A FBN1 FGF21 FZD7 GALNT11 GGH GIP GPX7 GYPA HSP90B1 HSPA13 IL6R IL6ST ITPRIP ITPRIPL1 KCNE5 KRT1 LAMP3 LAT LCN2 LHB LMO2 MYDGF NAXD NME3 OSMR PAGE3 PDIA6 PGRMC1 PODXL PPIB PPIC PRAP1 PRB1 PRB3 PRB4 PRR4 PSORS1C2 RAI2 RCN1 RNASE10 RNF144A RNF144B RNF170 SDC4 SDF2L1 SELENOM SERPINE1 SERPINF1 SERPINI2 SGCA SGTA SHISA5 SIL1 SLPI SOD3 SPINK4 SPP1 SRGN SYT11 SYT4 TFF1 TMEM108 TMEM123 TMPO TMUB1 TNFRSF19 TNFSF13 TXNDC12 UBL4A UPK3A VEGFC VWC2 WFDC12 ZG16 ZG16B	11 interacting genes: DNAJC5 EGFR ERBB2 ERBB4 GMPPA KPRP KRT31 KRTAP1-3 MMP9 SGTA SGTB
Entrez ID		54557	685
HPRD ID		18049	02643
Ensembl ID		ENSG00000197860	ENSG00000174808
Uniprot IDs		Q96EQ0	A0A0S2Z3I5 A0A0S2Z437 P35070
PDB IDs			1IOX 1IP0
Enriched GO Terms of Interacting Partners?
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