EXOC6 and EXOSC1

Data Source:
BioGRID (two hybrid)

		EXOC6	EXOSC1
Description		exocyst complex component 6	exosome component 1
Image		No pdb structure
GO Annotations	Cellular Component	Exocyst Cytosol Plasma Membrane Membrane Growth Cone Perinuclear Region Of Cytoplasm Flemming Body	Nuclear Exosome (RNase Complex) Exosome (RNase Complex) Nucleoplasm Nucleolus Cytoplasm Cytosol
	Molecular Function	Protein Binding	RNA Binding Exoribonuclease Activity Protein Binding
	Biological Process	Exocytosis Golgi To Plasma Membrane Transport Vesicle Docking Involved In Exocytosis Protein Transport	RRNA Processing Regulation Of MRNA Stability Exonucleolytic Catabolism Of Deadenylated MRNA RNA Phosphodiester Bond Hydrolysis, Exonucleolytic
Pathways		Translocation of SLC2A4 (GLUT4) to the plasma membrane Insulin processing VxPx cargo-targeting to cilium	ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases
GWAS		Age-related cognitive decline (attention/processing speed) (slope of z-scores) ( 30954325) Body mass index ( 28892062) Coronary artery disease ( 29212778) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Eosinophil percentage of white cells ( 32888494) Estimated glomerular filtration rate ( 31015462) Glaucoma (primary open-angle) ( 29449654) Hemoglobin A1c levels ( 29403010) High density lipoprotein cholesterol levels ( 29403010) Insulin levels in response to oral glucose tolerance test (30 minutes) ( 29093273) Intraocular pressure ( 30054594) Metabolic syndrome ( 31589552) Platelet distribution width ( 32888494) Refractive error ( 32231278) Total bilirubin levels ( 29403010)	Blood protein levels ( 30072576) Early spontaneous preterm birth ( 31194736) Spontaneous preterm birth with premature rupture of membranes ( 31194736)
Interacting Genes		12 interacting genes: APP CYP2C8 ECSIT EXOC5 EXOSC1 GCDH LOXL4 MAST1 NOS3 PRDX2 PSEN2 RNF32	34 interacting genes: A2M APP ASB9 CDC37 DDIT4L DMRTB1 ECSIT EXOC6 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 EXOSC9 FHL3 KCTD1 LNX1 LSM3 MAST1 MPHOSPH6 NOS3 NUP160 PAK5 PTEN RBPMS REL RNF32 SH3GLB2 TCF4 TEX11 UPF2 XRN1 ZNF143 ZNF76
Entrez ID		54536	51013
HPRD ID		10216	16223
Ensembl ID		ENSG00000138190	ENSG00000171311
Uniprot IDs		A5YP36 B2RDH5 B3KXY5 B7Z6G5 E7EW84 Q8TAG9	B1AMU3 Q9Y3B2
PDB IDs			2NN6 6D6Q 6D6R 6H25
Enriched GO Terms of Interacting Partners?
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