EXOC6 and ECSIT

Data Source:
BioGRID (two hybrid)

		EXOC6	ECSIT
Description		exocyst complex component 6	ECSIT signaling integrator
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Exocyst Cytosol Plasma Membrane Membrane Growth Cone Perinuclear Region Of Cytoplasm Flemming Body	Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Inner Membrane Cytosol
	Molecular Function	Protein Binding	Protein Binding
	Biological Process	Exocytosis Golgi To Plasma Membrane Transport Vesicle Docking Involved In Exocytosis Protein Transport	Mitochondrial Respiratory Chain Complex I Assembly Innate Immune Response Regulation Of Oxidoreductase Activity Regulation Of Protein Complex Stability
Pathways		Translocation of SLC2A4 (GLUT4) to the plasma membrane Insulin processing VxPx cargo-targeting to cilium	MyD88:MAL(TIRAP) cascade initiated on plasma membrane Complex I biogenesis TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88 cascade initiated on plasma membrane
Drugs
Diseases
GWAS		Age-related cognitive decline (attention/processing speed) (slope of z-scores) ( 30954325) Body mass index ( 28892062) Coronary artery disease ( 29212778) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Eosinophil percentage of white cells ( 32888494) Estimated glomerular filtration rate ( 31015462) Glaucoma (primary open-angle) ( 29449654) Hemoglobin A1c levels ( 29403010) High density lipoprotein cholesterol levels ( 29403010) Insulin levels in response to oral glucose tolerance test (30 minutes) ( 29093273) Intraocular pressure ( 30054594) Metabolic syndrome ( 31589552) Platelet distribution width ( 32888494) Refractive error ( 32231278) Total bilirubin levels ( 29403010)	Presence of antiphospholipid antibodies ( 27098658)
Interacting Genes		12 interacting genes: APP CYP2C8 ECSIT EXOC5 EXOSC1 GCDH LOXL4 MAST1 NOS3 PRDX2 PSEN2 RNF32	52 interacting genes: A2M AP1M2 APOE APP BFSP2 BLMH C1orf109 CDC37 CEP55 CTNNA3 CYP2C18 CYP2C8 CYP2C9 DNAJB1 DTX2 ELAVL3 EXOC6 EXOSC1 FARSA FBXL12 FBXW4 GCDH GEM IFIT3 IFIT5 IMMT LONP1 LOXL4 MAGEB2 MAST1 MKRN3 NFKB1 NXF1 PAXIP1 PI4K2A PRDX2 PSEN1 RAB3A RAD23A RELA RHEB RNF32 SETDB1 SMAD1 SMAD4 SMURF1 STAMBPL1 STRN4 TARS3 TRAF6 TRIM59 TSSK3
Entrez ID		54536	51295
HPRD ID		10216	12225
Ensembl ID		ENSG00000138190	ENSG00000130159
Uniprot IDs		A5YP36 B2RDH5 B3KXY5 B7Z6G5 E7EW84 Q8TAG9	Q9BQ95
PDB IDs
Enriched GO Terms of Interacting Partners?
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