NLE1 and CHRM5

Data Source:
BioGRID (two hybrid)

		NLE1	CHRM5
Description		notchless homolog 1	cholinergic receptor muscarinic 5
Image
GO Annotations	Cellular Component	Nucleoplasm Nucleolus	Plasma Membrane Integral Component Of Plasma Membrane Dendrite Synapse Postsynaptic Membrane
	Molecular Function		Phosphatidylinositol Phospholipase C Activity G Protein-coupled Serotonin Receptor Activity Protein Binding G Protein-coupled Acetylcholine Receptor Activity Neurotransmitter Receptor Activity
	Biological Process	Ribosomal Large Subunit Assembly Somitogenesis Kidney Development Inner Cell Mass Cell Differentiation Notch Signaling Pathway Negative Regulation Of Mitotic Cell Cycle Skeletal System Morphogenesis Hematopoietic Stem Cell Homeostasis Positive Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway	Gastric Acid Secretion G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting G Protein-coupled Acetylcholine Receptor Signaling Pathway G Protein-coupled Acetylcholine Receptor Signaling Pathway Chemical Synaptic Transmission Dopamine Transport Transmission Of Nerve Impulse Regulation Of Phosphatidylinositol Dephosphorylation G Protein-coupled Serotonin Receptor Signaling Pathway
Pathways			Muscarinic acetylcholine receptors G alpha (q) signalling events
Drugs			Ziprasidone Amitriptyline Metixene Terfenadine Clozapine Doxylamine Trihexyphenidyl Loxapine Meperidine Imipramine Darifenacin Nortriptyline Amoxapine Cinnarizine Atropine Nicardipine Paroxetine Homatropine methylbromide Trimipramine Scopolamine Benzquinamide Propiomazine Brompheniramine Maprotiline Methantheline Tolterodine Promethazine Doxepin Desipramine Ketamine Quetiapine Aripiprazole Chlorprothixene Methotrimeprazine Tiotropium Solifenacin ALKS 27 Fesoterodine Aclidinium Umeclidinium Dosulepin Etoperidone Homatropine Thonzylamine Revefenacin Propiverine Rociverine Aripiprazole lauroxil
Diseases
GWAS			Malaria ( 31844061)
Interacting Genes		2 interacting genes: CHRM5 EWSR1	31 interacting genes: ASPH ASTN2 ATP2A2 ATP9A CBFB CD82 EPB41L1 EPC1 ERCC1 GJB6 GOLGA8A GPRASP1 HLA-F MAP3K1 MSMO1 MYH7 NLE1 NPAS3 PRSS16 REEP5 RGS7 RTN1 SLC2A6 SLC5A6 SLC6A8 SMAD6 SNCA SPNS1 STARD3NL TMEM161A USP33
Entrez ID		54475	1133
HPRD ID		16903	00331
Ensembl ID		ENSG00000073536	ENSG00000184984
Uniprot IDs		Q9NVX2	A0A024R9I2 P08912 Q8IVW0
PDB IDs		6WAJ	6OL9
Enriched GO Terms of Interacting Partners?
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