CHRM5 and NPAS3

Data Source:
BioGRID (two hybrid)

		CHRM5	NPAS3
Description		cholinergic receptor muscarinic 5	neuronal PAS domain protein 3
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Dendrite Synapse Postsynaptic Membrane	Chromatin Nucleoplasm
	Molecular Function	Phosphatidylinositol Phospholipase C Activity G Protein-coupled Serotonin Receptor Activity Protein Binding G Protein-coupled Acetylcholine Receptor Activity Neurotransmitter Receptor Activity	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Heterodimerization Activity
	Biological Process	Gastric Acid Secretion G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting G Protein-coupled Acetylcholine Receptor Signaling Pathway G Protein-coupled Acetylcholine Receptor Signaling Pathway Chemical Synaptic Transmission Dopamine Transport Transmission Of Nerve Impulse Regulation Of Phosphatidylinositol Dephosphorylation G Protein-coupled Serotonin Receptor Signaling Pathway	Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription, DNA-templated
Pathways		Muscarinic acetylcholine receptors G alpha (q) signalling events
Drugs		Ziprasidone Amitriptyline Metixene Terfenadine Clozapine Doxylamine Trihexyphenidyl Loxapine Meperidine Imipramine Darifenacin Nortriptyline Amoxapine Cinnarizine Atropine Nicardipine Paroxetine Homatropine methylbromide Trimipramine Scopolamine Benzquinamide Propiomazine Brompheniramine Maprotiline Methantheline Tolterodine Promethazine Doxepin Desipramine Ketamine Quetiapine Aripiprazole Chlorprothixene Methotrimeprazine Tiotropium Solifenacin ALKS 27 Fesoterodine Aclidinium Umeclidinium Dosulepin Etoperidone Homatropine Thonzylamine Revefenacin Propiverine Rociverine Aripiprazole lauroxil
Diseases
GWAS		Malaria ( 31844061)	Alcoholic chronic pancreatitis ( 28754779) anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Arterial stiffness index ( 31235810) Bipolar disorder ( 31043756) Body mass index ( 26426971 28892062 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index in physically active individuals ( 28448500) Coffee consumption ( 31046077) Colorectal or endometrial cancer ( 26621817) Diisocyanate-induced asthma ( 25918132) Familial squamous cell lung carcinoma ( 29924316) Height ( 28552196) Inflammatory biomarkers ( 22228203) Intraocular pressure ( 29617998) Lean body mass ( 28552196) Metabolite levels ( 23823483) Mitochondrial DNA levels ( 25240745) Moderate-to-late spontaneous preterm birth ( 31194736) Modified Stumvoll Insulin Sensitivity Index (BMI interaction) ( 27416945) Night sleep phenotypes ( 27126917) Plasma amyloid beta peptide concentrations (ABx-40) ( 24535457) QRS duration in Tripanosoma cruzi seropositivity ( 24324551) Schizophrenia ( 28991256) Schizophrenia, bipolar disorder and depression (combined) ( 20713499) Serum immune biomarker levels ( 32066700) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Squamous cell lung carcinoma ( 28604730)
Interacting Genes		31 interacting genes: ASPH ASTN2 ATP2A2 ATP9A CBFB CD82 EPB41L1 EPC1 ERCC1 GJB6 GOLGA8A GPRASP1 HLA-F MAP3K1 MSMO1 MYH7 NLE1 NPAS3 PRSS16 REEP5 RGS7 RTN1 SLC2A6 SLC5A6 SLC6A8 SMAD6 SNCA SPNS1 STARD3NL TMEM161A USP33	2 interacting genes: ARNT2 CHRM5
Entrez ID		1133	64067
HPRD ID		00331	11400
Ensembl ID		ENSG00000184984	ENSG00000151322
Uniprot IDs		A0A024R9I2 P08912 Q8IVW0	Q8IXF0 X5D2Q4 X5D7M0 X5D988
PDB IDs		6OL9
Enriched GO Terms of Interacting Partners?
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