CHRM5 and NLE1

Data Source:
BioGRID (two hybrid)

		CHRM5	NLE1
Description		cholinergic receptor muscarinic 5	notchless homolog 1
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GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Dendrite Synapse Postsynaptic Membrane	Nucleoplasm Nucleolus
	Molecular Function	Phosphatidylinositol Phospholipase C Activity G Protein-coupled Serotonin Receptor Activity Protein Binding G Protein-coupled Acetylcholine Receptor Activity Neurotransmitter Receptor Activity
	Biological Process	Gastric Acid Secretion G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting G Protein-coupled Acetylcholine Receptor Signaling Pathway G Protein-coupled Acetylcholine Receptor Signaling Pathway Chemical Synaptic Transmission Dopamine Transport Transmission Of Nerve Impulse Regulation Of Phosphatidylinositol Dephosphorylation G Protein-coupled Serotonin Receptor Signaling Pathway	Ribosomal Large Subunit Assembly Somitogenesis Kidney Development Inner Cell Mass Cell Differentiation Notch Signaling Pathway Negative Regulation Of Mitotic Cell Cycle Skeletal System Morphogenesis Hematopoietic Stem Cell Homeostasis Positive Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway
Pathways		Muscarinic acetylcholine receptors G alpha (q) signalling events
Drugs		Ziprasidone Amitriptyline Metixene Terfenadine Clozapine Doxylamine Trihexyphenidyl Loxapine Meperidine Imipramine Darifenacin Nortriptyline Amoxapine Cinnarizine Atropine Nicardipine Paroxetine Homatropine methylbromide Trimipramine Scopolamine Benzquinamide Propiomazine Brompheniramine Maprotiline Methantheline Tolterodine Promethazine Doxepin Desipramine Ketamine Quetiapine Aripiprazole Chlorprothixene Methotrimeprazine Tiotropium Solifenacin ALKS 27 Fesoterodine Aclidinium Umeclidinium Dosulepin Etoperidone Homatropine Thonzylamine Revefenacin Propiverine Rociverine Aripiprazole lauroxil
Diseases
GWAS		Malaria ( 31844061)
Interacting Genes		31 interacting genes: ASPH ASTN2 ATP2A2 ATP9A CBFB CD82 EPB41L1 EPC1 ERCC1 GJB6 GOLGA8A GPRASP1 HLA-F MAP3K1 MSMO1 MYH7 NLE1 NPAS3 PRSS16 REEP5 RGS7 RTN1 SLC2A6 SLC5A6 SLC6A8 SMAD6 SNCA SPNS1 STARD3NL TMEM161A USP33	2 interacting genes: CHRM5 EWSR1
Entrez ID		1133	54475
HPRD ID		00331	16903
Ensembl ID		ENSG00000184984	ENSG00000073536
Uniprot IDs		A0A024R9I2 P08912 Q8IVW0	Q9NVX2
PDB IDs		6OL9	6WAJ
Enriched GO Terms of Interacting Partners?
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