RIN2 and RAB5B

Data Source:
HPRD (in vitro, two hybrid)

		RIN2	RAB5B
Description		Ras and Rab interactor 2	RAB5B, member RAS oncogene family
Image		No pdb structure
GO Annotations	Cellular Component	Cellular_component Cytosol	Endosome Early Endosome Plasma Membrane Endomembrane System Membrane Endocytic Vesicle Secretory Granule Membrane Early Endosome Membrane Melanosome Intracellular Membrane-bounded Organelle Extracellular Exosome Anchored Component Of Synaptic Vesicle Membrane
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity GTPase Regulator Activity	GTPase Activity Protein Binding GTP Binding GDP Binding GTP-dependent Protein Binding
	Biological Process	Endocytosis Small GTPase Mediated Signal Transduction Positive Regulation Of Endothelial Cell Migration Positive Regulation Of GTPase Activity Positive Regulation Of Endothelial Cell-matrix Adhesion Via Fibronectin Positive Regulation Of Vasculogenesis	Intracellular Protein Transport Endocytosis Endosome Organization Antigen Processing And Presentation Regulation Of Endocytosis Neutrophil Degranulation Plasma Membrane To Endosome Transport
Pathways		RAB GEFs exchange GTP for GDP on RABs	Neutrophil degranulation TBC/RABGAPs Clathrin-mediated endocytosis RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases		Macrocephaly, alopecia, cutis laxa, and scoliosis; MACS syndrome
GWAS		Bipolar disorder and schizophrenia ( 20889312) Bone mineral density (total hip) ( 29883787) Femoral neck bone mineral density and trunk fat mass adjusted by trunk lean mass ( 32239398) HDL cholesterol ( 31170924) Metabolite levels ( 23823483) Obesity-related traits ( 23251661) Platelet distribution width ( 32888494 27863252) Response to valproic acid in genetic generalized epilepsy ( 32308125) Smoking status (ever vs never smokers) ( 30643258) Trunk fat mass adjusted for trunk lean mass ( 32239398) Verbal declarative memory ( 25648963) Weight ( 28552196)	Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29785011) Anorexia nervosa ( 28494655) Asthma ( 31959851 30929738 31619474) Asthma (adult onset) ( 31036433) Asthma (childhood onset) ( 31036433 30929738) Asthma or allergic disease (pleiotropy) ( 29785011) Brain morphology (MOSTest) ( 32665545) Cognitive function ( 25644384) FEV1 ( 30804560) Gastroesophageal reflux disease ( 31527586) HDL cholesterol levels ( 32203549) High density lipoprotein cholesterol levels ( 31928498) Lung function (FEV1) ( 30061609) Lung function (FEV1/FVC) ( 30804560) Medication use (drugs for peptic ulcer and gastro-oesophageal reflux disease) ( 31015401) Polycystic ovary syndrome ( 22885925 30566500) Refractive error ( 32231278) Sum eosinophil basophil counts ( 27863252) Type 1 diabetes ( 18198356) Vitiligo ( 22951725)
Interacting Genes		7 interacting genes: BIN1 CDKN2A EGFR ERBB2 RAB5A RAB5B RAB5C	16 interacting genes: APOA5 CDK1 CHM EEA1 GLP1R PIK3CB RABAC1 REEP5 RIN1 RIN2 RIN3 SGSM3 SUN2 TBC1D15 TBC1D17 TFRC
Entrez ID		54453	5869
HPRD ID		15249	01544
Ensembl ID		ENSG00000132669	ENSG00000111540
Uniprot IDs		A1A4T0 Q8WYP3	A0A024RB09 P61020
PDB IDs			2HEI
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?