RAB5B and TBC1D17

Data Source:
BioGRID (two hybrid)

		RAB5B	TBC1D17
Description		RAB5B, member RAS oncogene family	TBC1 domain family member 17
Image			No pdb structure
GO Annotations	Cellular Component	Endosome Early Endosome Plasma Membrane Endomembrane System Membrane Endocytic Vesicle Secretory Granule Membrane Early Endosome Membrane Melanosome Intracellular Membrane-bounded Organelle Extracellular Exosome Anchored Component Of Synaptic Vesicle Membrane	Autophagosome Cytosol Recycling Endosome
	Molecular Function	GTPase Activity Protein Binding GTP Binding GDP Binding GTP-dependent Protein Binding	GTPase Activator Activity Protein Binding
	Biological Process	Intracellular Protein Transport Endocytosis Endosome Organization Antigen Processing And Presentation Regulation Of Endocytosis Neutrophil Degranulation Plasma Membrane To Endosome Transport	Intracellular Protein Transport Autophagy Retrograde Transport, Endosome To Golgi Activation Of GTPase Activity Regulation Of Cilium Assembly
Pathways		Neutrophil degranulation TBC/RABGAPs Clathrin-mediated endocytosis RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs	TBC/RABGAPs
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29785011) Anorexia nervosa ( 28494655) Asthma ( 31959851 30929738 31619474) Asthma (adult onset) ( 31036433) Asthma (childhood onset) ( 31036433 30929738) Asthma or allergic disease (pleiotropy) ( 29785011) Brain morphology (MOSTest) ( 32665545) Cognitive function ( 25644384) FEV1 ( 30804560) Gastroesophageal reflux disease ( 31527586) HDL cholesterol levels ( 32203549) High density lipoprotein cholesterol levels ( 31928498) Lung function (FEV1) ( 30061609) Lung function (FEV1/FVC) ( 30804560) Medication use (drugs for peptic ulcer and gastro-oesophageal reflux disease) ( 31015401) Polycystic ovary syndrome ( 22885925 30566500) Refractive error ( 32231278) Sum eosinophil basophil counts ( 27863252) Type 1 diabetes ( 18198356) Vitiligo ( 22951725)
Interacting Genes		16 interacting genes: APOA5 CDK1 CHM EEA1 GLP1R PIK3CB RABAC1 REEP5 RIN1 RIN2 RIN3 SGSM3 SUN2 TBC1D15 TBC1D17 TFRC	19 interacting genes: ASCC2 CALCOCO1 CCT5 CDKN2D DHX29 FBL GABARAPL1 GPS1 GTF3C1 MAP1LC3A MAP1LC3B NIPSNAP1 OPTN RAB1A RAB5A RAB5B RAB5C SLC1A5 TAX1BP1
Entrez ID		5869	79735
HPRD ID		01544	15471
Ensembl ID		ENSG00000111540	ENSG00000104946
Uniprot IDs		A0A024RB09 P61020	Q9HA65
PDB IDs		2HEI
Enriched GO Terms of Interacting Partners?
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