RIN2 and RAB5A

Data Source:
HPRD (two hybrid)

		RIN2	RAB5A
Description		Ras and Rab interactor 2	RAB5A, member RAS oncogene family
Image		No pdb structure
GO Annotations	Cellular Component	Cellular_component Cytosol	Ruffle Nucleoplasm Cytoplasm Endosome Early Endosome Cytosol Plasma Membrane Synaptic Vesicle Endosome Membrane Endomembrane System Actin Cytoskeleton Endocytic Vesicle Axon Dendrite Clathrin-coated Vesicle Membrane Phagocytic Vesicle Membrane Early Endosome Membrane Early Phagosome Somatodendritic Compartment Melanosome Neuronal Cell Body Terminal Bouton Intracellular Membrane-bounded Organelle Axon Terminus Membrane Raft Phagocytic Vesicle Extracellular Exosome Cytoplasmic Side Of Early Endosome Membrane Postsynaptic Early Endosome Anchored Component Of Synaptic Vesicle Membrane
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity GTPase Regulator Activity	GTPase Activity Protein Binding GTP Binding GDP Binding
	Biological Process	Endocytosis Small GTPase Mediated Signal Transduction Positive Regulation Of Endothelial Cell Migration Positive Regulation Of GTPase Activity Positive Regulation Of Endothelial Cell-matrix Adhesion Via Fibronectin Positive Regulation Of Vasculogenesis	Phosphatidylinositol Biosynthetic Process Intracellular Protein Transport Endocytosis Phagocytosis Blood Coagulation Regulation Of Endocytosis Synaptic Vesicle Recycling Viral RNA Genome Replication Post-translational Protein Modification Early Endosome To Late Endosome Transport Positive Regulation Of Exocytosis Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Endosome Size Regulation Of Filopodium Assembly Membrane Organization Amyloid-beta Clearance By Transcytosis Receptor Internalization Involved In Canonical Wnt Signaling Pathway Regulation Of Synaptic Vesicle Exocytosis Regulation Of Autophagosome Assembly
Pathways		RAB GEFs exchange GTP for GDP on RABs	Synthesis of PIPs at the plasma membrane TBC/RABGAPs Clathrin-mediated endocytosis RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs Prevention of phagosomal-lysosomal fusion Factors involved in megakaryocyte development and platelet production
Drugs			L-methionine (S)-S-oxide Guanosine-5'-Triphosphate Guanosine-5'-Diphosphate
Diseases		Macrocephaly, alopecia, cutis laxa, and scoliosis; MACS syndrome
GWAS		Bipolar disorder and schizophrenia ( 20889312) Bone mineral density (total hip) ( 29883787) Femoral neck bone mineral density and trunk fat mass adjusted by trunk lean mass ( 32239398) HDL cholesterol ( 31170924) Metabolite levels ( 23823483) Obesity-related traits ( 23251661) Platelet distribution width ( 32888494 27863252) Response to valproic acid in genetic generalized epilepsy ( 32308125) Smoking status (ever vs never smokers) ( 30643258) Trunk fat mass adjusted for trunk lean mass ( 32239398) Verbal declarative memory ( 25648963) Weight ( 28552196)	Heel bone mineral density ( 30598549) Iris color (L* coordinate) ( 30895295)
Interacting Genes		7 interacting genes: BIN1 CDKN2A EGFR ERBB2 RAB5A RAB5B RAB5C	35 interacting genes: AGTR1 ALS2CL ANKFY1 APPL1 APPL2 CHML EEA1 GDI2 GRIK4 HTATIP2 ITSN1 NME2 OCRL RAB37 RABAC1 RABEP1 RABEP2 RABGGTB RASA1 RBSN RIN1 RIN2 RIN3 RIT2 RUFY1 SDCBP SGSM3 STX4 TBC1D15 TBC1D17 TBC1D3C TBC1D3F TRIM14 TSC2 USP6NL
Entrez ID		54453	5868
HPRD ID		15249	01542
Ensembl ID		ENSG00000132669	ENSG00000144566
Uniprot IDs		A1A4T0 Q8WYP3	A0A024R2K1 P20339
PDB IDs			1N6H 1N6I 1N6K 1N6L 1N6N 1N6O 1N6P 1N6R 1R2Q 1TU3 1TU4 3MJH 4Q9U
Enriched GO Terms of Interacting Partners?
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