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POLR2K and SMYD3
Data Source:
HPRD
(in vivo, in vitro)
POLR2K
SMYD3
Description
RNA polymerase II, I and III subunit K
SET and MYND domain containing 3
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
RNA Polymerase II, Core Complex
RNA Polymerase III Complex
RNA Polymerase I Complex
Cytosol
Nucleus
Nucleoplasm
Cytosol
Molecular Function
DNA Binding
DNA-directed 5'-3' RNA Polymerase Activity
Protein Binding
Zinc Ion Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Complex Binding
RNA Polymerase II Intronic Transcription Regulatory Region Sequence-specific DNA Binding
Protein Binding
Histone-lysine N-methyltransferase Activity
Metal Ion Binding
Biological Process
MRNA Splicing, Via Spliceosome
Transcription-coupled Nucleotide-excision Repair
Transcription, DNA-templated
Regulation Of Transcription By RNA Polymerase I
Transcription Initiation From RNA Polymerase I Promoter
Transcription Elongation From RNA Polymerase I Promoter
Termination Of RNA Polymerase I Transcription
Transcription By RNA Polymerase II
Transcription Initiation From RNA Polymerase II Promoter
Transcription Elongation From RNA Polymerase II Promoter
7-methylguanosine MRNA Capping
Transcription By RNA Polymerase III
Fibroblast Growth Factor Receptor Signaling Pathway
RNA Metabolic Process
Positive Regulation Of Type I Interferon Production
Somatic Stem Cell Population Maintenance
SnRNA Transcription By RNA Polymerase II
Positive Regulation Of Gene Expression, Epigenetic
Positive Regulation Of Viral Transcription
Regulation Of Gene Silencing By MiRNA
Nucleosome Assembly
Negative Regulation Of Protein Kinase Activity
Myotube Cell Development
Positive Regulation Of Peptidyl-serine Phosphorylation
Histone Lysine Methylation
Establishment Of Protein Localization
Positive Regulation Of Transcription By RNA Polymerase II
Cellular Response To Dexamethasone Stimulus
Pathways
Formation of RNA Pol II elongation complex
Formation of the Early Elongation Complex
Formation of HIV elongation complex in the absence of HIV Tat
Formation of the HIV-1 Early Elongation Complex
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection
HIV Transcription Initiation
RNA Polymerase II HIV Promoter Escape
Transcription of the HIV genome
Formation of HIV-1 elongation complex containing HIV-1 Tat
Formation of HIV-1 elongation complex containing HIV-1 Tat
Pausing and recovery of Tat-mediated HIV elongation
Abortive elongation of HIV-1 transcript in the absence of Tat
Tat-mediated HIV elongation arrest and recovery
Tat-mediated elongation of the HIV-1 transcript
HIV elongation arrest and recovery
Pausing and recovery of HIV elongation
Viral Messenger RNA Synthesis
Cytosolic sensors of pathogen-associated DNA
MicroRNA (miRNA) biogenesis
NoRC negatively regulates rRNA expression
B-WICH complex positively regulates rRNA expression
Transcriptional regulation by small RNAs
PIWI-interacting RNA (piRNA) biogenesis
Activation of anterior HOX genes in hindbrain development during early embryogenesis
RNA Polymerase II Pre-transcription Events
Formation of TC-NER Pre-Incision Complex
Transcription-Coupled Nucleotide Excision Repair (TC-NER)
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
TP53 Regulates Transcription of DNA Repair Genes
FGFR2 alternative splicing
RNA polymerase II transcribes snRNA genes
RNA polymerase II transcribes snRNA genes
mRNA Capping
mRNA Splicing - Major Pathway
mRNA Splicing - Minor Pathway
Processing of Capped Intron-Containing Pre-mRNA
RNA Polymerase I Transcription Initiation
RNA Polymerase I Transcription Initiation
RNA Polymerase I Promoter Escape
RNA Polymerase II Promoter Escape
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
RNA Polymerase III Chain Elongation
RNA Polymerase I Transcription Termination
RNA Polymerase III Transcription Termination
RNA Polymerase III Abortive And Retractive Initiation
RNA Polymerase II Transcription Initiation
RNA Polymerase II Transcription Elongation
RNA Polymerase II Transcription Initiation And Promoter Clearance
RNA Polymerase III Transcription Initiation From Type 1 Promoter
RNA Polymerase III Transcription Initiation From Type 1 Promoter
RNA Polymerase III Transcription Initiation From Type 2 Promoter
RNA Polymerase III Transcription Initiation From Type 2 Promoter
RNA Polymerase III Transcription Initiation From Type 3 Promoter
RNA Polymerase III Transcription Initiation From Type 3 Promoter
RNA Pol II CTD phosphorylation and interaction with CE
Signaling by FGFR2 IIIa TM
Estrogen-dependent gene expression
Inhibition of DNA recombination at telomere
PKMTs methylate histone lysines
Drugs
Diseases
GWAS
Bipolar disorder (
31043756
)
Blood metabolite levels (
26401656
)
Coffee consumption (
31046077
)
Electrocardiogram morphology (amplitude at temporal datapoints) (
32916098
)
Fractional exhaled nitric oxide (childhood) (
24315451
)
Gut microbiota relative abundance (Bifidobacterium) (
33208821
)
Malaria (
31844061
)
Obesity-related traits (
23251661
)
Post bronchodilator FEV1 (
26634245
)
PR interval (
32439900
)
Renal underexcretion gout (
32238385
)
Response to serotonin reuptake inhibitors in non-psychotic unipolar depression (
26348319
)
Systemic lupus erythematosus (
29848360
)
Upper eyelid sagging severity (
24869959
)
Interacting Genes
13 interacting genes:
APP
BRCA1
FBXO7
POLR2B
POLR2C
POLR2D
POLR2E
POLR2F
POLR2G
POLR2H
POLR2J
SH3KBP1
SMYD3
21 interacting genes:
APP
CAMK2B
CSTF2T
CYP39A1
EED
EZH2
H3-4
H3-5
HELZ
HSP90AA1
MKRN3
NDUFAB1
NFYB
NUP54
PBX2
PKN1
POLR2K
SHC3
TRIT1
VANGL1
ZNF557
Entrez ID
5440
64754
HPRD ID
05826
12297
Ensembl ID
ENSG00000147669
ENSG00000185420
Uniprot IDs
A0A024R9G0
P53803
B3KN46
Q9H7B4
PDB IDs
5IY6
5IY7
5IY8
5IY9
5IYA
5IYB
5IYC
5IYD
6DRD
6O9L
3MEK
3OXF
3OXG
3OXL
3PDN
3QWP
3RU0
5CCL
5CCM
5EX0
5EX3
5HI7
5HQ8
5V37
5XXD
5XXG
5XXJ
5YJO
6IJL
6O9O
6P6G
6P6K
6P7Z
6PAF
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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