SMYD3 and CSTF2T

Data Source:
BioGRID (two hybrid)

		SMYD3	CSTF2T
Description		SET and MYND domain containing 3	cleavage stimulation factor subunit 2 tau variant
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol	Nucleoplasm MRNA Cleavage And Polyadenylation Specificity Factor Complex Intracellular Membrane-bounded Organelle
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding RNA Polymerase II Complex Binding RNA Polymerase II Intronic Transcription Regulatory Region Sequence-specific DNA Binding Protein Binding Histone-lysine N-methyltransferase Activity Metal Ion Binding	RNA Binding MRNA Binding Protein Binding
	Biological Process	Nucleosome Assembly Negative Regulation Of Protein Kinase Activity Myotube Cell Development Positive Regulation Of Peptidyl-serine Phosphorylation Histone Lysine Methylation Establishment Of Protein Localization Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Dexamethasone Stimulus	MRNA Splicing, Via Spliceosome Termination Of RNA Polymerase II Transcription MRNA 3'-end Processing Pre-mRNA Cleavage Required For Polyadenylation
Pathways		PKMTs methylate histone lysines	mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination Processing of Intronless Pre-mRNAs
Drugs
Diseases
GWAS		Bipolar disorder ( 31043756) Blood metabolite levels ( 26401656) Coffee consumption ( 31046077) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Fractional exhaled nitric oxide (childhood) ( 24315451) Gut microbiota relative abundance (Bifidobacterium) ( 33208821) Malaria ( 31844061) Obesity-related traits ( 23251661) Post bronchodilator FEV1 ( 26634245) PR interval ( 32439900) Renal underexcretion gout ( 32238385) Response to serotonin reuptake inhibitors in non-psychotic unipolar depression ( 26348319) Systemic lupus erythematosus ( 29848360) Upper eyelid sagging severity ( 24869959)	Interferon alpha levels in systemic lupus erythematosus ( 25338677) Logical memory (delayed recall) in normal cognition ( 29274321) Mammographic density (non-dense area) ( 25342443)
Interacting Genes		21 interacting genes: APP CAMK2B CSTF2T CYP39A1 EED EZH2 H3-4 H3-5 HELZ HSP90AA1 MKRN3 NDUFAB1 NFYB NUP54 PBX2 PKN1 POLR2K SHC3 TRIT1 VANGL1 ZNF557	23 interacting genes: AKAP8L ATP23 CDSN COL17A1 CPSF1 CTAG1A CTAG1B CTDSP1 FAM168B FOXI1 FOXJ2 GOLGA2 HGS LASP1 PKNOX2 SMYD3 SPAG8 STH TLE5 TOX2 UBQLN1 UBQLN2 UBQLN4
Entrez ID		64754	23283
HPRD ID		12297	09900
Ensembl ID		ENSG00000185420	ENSG00000177613
Uniprot IDs		B3KN46 Q9H7B4	Q9H0L4
PDB IDs		3MEK 3OXF 3OXG 3OXL 3PDN 3QWP 3RU0 5CCL 5CCM 5EX0 5EX3 5HI7 5HQ8 5V37 5XXD 5XXG 5XXJ 5YJO 6IJL 6O9O 6P6G 6P6K 6P7Z 6PAF
Enriched GO Terms of Interacting Partners?
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