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POLR2K and SH3KBP1
Data Source:
BioGRID
(two hybrid)
POLR2K
SH3KBP1
Description
RNA polymerase II, I and III subunit K
SH3 domain containing kinase binding protein 1
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
RNA Polymerase II, Core Complex
RNA Polymerase III Complex
RNA Polymerase I Complex
Cytosol
Cytoplasm
Cytosol
Cytoskeleton
Plasma Membrane
Cell-cell Junction
Focal Adhesion
Endocytic Vesicle
Cytoplasmic Vesicle Membrane
Neuron Projection
Synapse
Molecular Function
DNA Binding
DNA-directed 5'-3' RNA Polymerase Activity
Protein Binding
Zinc Ion Binding
Protein Binding
SH3 Domain Binding
Biological Process
MRNA Splicing, Via Spliceosome
Transcription-coupled Nucleotide-excision Repair
Transcription, DNA-templated
Regulation Of Transcription By RNA Polymerase I
Transcription Initiation From RNA Polymerase I Promoter
Transcription Elongation From RNA Polymerase I Promoter
Termination Of RNA Polymerase I Transcription
Transcription By RNA Polymerase II
Transcription Initiation From RNA Polymerase II Promoter
Transcription Elongation From RNA Polymerase II Promoter
7-methylguanosine MRNA Capping
Transcription By RNA Polymerase III
Fibroblast Growth Factor Receptor Signaling Pathway
RNA Metabolic Process
Positive Regulation Of Type I Interferon Production
Somatic Stem Cell Population Maintenance
SnRNA Transcription By RNA Polymerase II
Positive Regulation Of Gene Expression, Epigenetic
Positive Regulation Of Viral Transcription
Regulation Of Gene Silencing By MiRNA
Endocytosis
Apoptotic Process
Cytoskeleton Organization
Actin Filament Organization
Cell-cell Signaling
Axon Guidance
Regulation Of Cell Shape
Cell Migration
Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Positive Regulation Of B Cell Activation
Membrane Organization
Pathways
Formation of RNA Pol II elongation complex
Formation of the Early Elongation Complex
Formation of HIV elongation complex in the absence of HIV Tat
Formation of the HIV-1 Early Elongation Complex
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection
HIV Transcription Initiation
RNA Polymerase II HIV Promoter Escape
Transcription of the HIV genome
Formation of HIV-1 elongation complex containing HIV-1 Tat
Formation of HIV-1 elongation complex containing HIV-1 Tat
Pausing and recovery of Tat-mediated HIV elongation
Abortive elongation of HIV-1 transcript in the absence of Tat
Tat-mediated HIV elongation arrest and recovery
Tat-mediated elongation of the HIV-1 transcript
HIV elongation arrest and recovery
Pausing and recovery of HIV elongation
Viral Messenger RNA Synthesis
Cytosolic sensors of pathogen-associated DNA
MicroRNA (miRNA) biogenesis
NoRC negatively regulates rRNA expression
B-WICH complex positively regulates rRNA expression
Transcriptional regulation by small RNAs
PIWI-interacting RNA (piRNA) biogenesis
Activation of anterior HOX genes in hindbrain development during early embryogenesis
RNA Polymerase II Pre-transcription Events
Formation of TC-NER Pre-Incision Complex
Transcription-Coupled Nucleotide Excision Repair (TC-NER)
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
TP53 Regulates Transcription of DNA Repair Genes
FGFR2 alternative splicing
RNA polymerase II transcribes snRNA genes
RNA polymerase II transcribes snRNA genes
mRNA Capping
mRNA Splicing - Major Pathway
mRNA Splicing - Minor Pathway
Processing of Capped Intron-Containing Pre-mRNA
RNA Polymerase I Transcription Initiation
RNA Polymerase I Transcription Initiation
RNA Polymerase I Promoter Escape
RNA Polymerase II Promoter Escape
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
RNA Polymerase III Chain Elongation
RNA Polymerase I Transcription Termination
RNA Polymerase III Transcription Termination
RNA Polymerase III Abortive And Retractive Initiation
RNA Polymerase II Transcription Initiation
RNA Polymerase II Transcription Elongation
RNA Polymerase II Transcription Initiation And Promoter Clearance
RNA Polymerase III Transcription Initiation From Type 1 Promoter
RNA Polymerase III Transcription Initiation From Type 1 Promoter
RNA Polymerase III Transcription Initiation From Type 2 Promoter
RNA Polymerase III Transcription Initiation From Type 2 Promoter
RNA Polymerase III Transcription Initiation From Type 3 Promoter
RNA Polymerase III Transcription Initiation From Type 3 Promoter
RNA Pol II CTD phosphorylation and interaction with CE
Signaling by FGFR2 IIIa TM
Estrogen-dependent gene expression
Inhibition of DNA recombination at telomere
EGFR downregulation
Negative regulation of MET activity
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
Reelin signalling pathway
InlB-mediated entry of Listeria monocytogenes into host cell
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Drugs
Diseases
GWAS
Platelet count (
32888494
)
Interacting Genes
13 interacting genes:
APP
BRCA1
FBXO7
POLR2B
POLR2C
POLR2D
POLR2E
POLR2F
POLR2G
POLR2H
POLR2J
SH3KBP1
SMYD3
58 interacting genes:
ABI2
ANKS1A
ARAP3
ARHGAP27
ASAP1
ASAP2
BCAR1
BHLHB9
BLNK
BMPR1B
CAPZA1
CBL
CBLB
CCDC57
CCDC88B
CD2
CYSRT1
DENND2A
GGN
GRB2
HCK
HIVEP1
INPP5D
ITSN2
KPRP
KRTAP6-3
LZTS2
MVB12A
NEDD4
NELFA
PAK2
PDCD6
PDCD6IP
PIK3CA
PIK3R1
PNMA5
POLR2K
PSMA3
SEPTIN2
SEPTIN6
SH3BP2
SH3GL2
SH3GL3
SH3GLB1
SH3GLB2
SHKBP1
SOS1
SPRY2
STAP1
SYNJ1
TAF6
TJP2
TP53BP2
UBB
UBC
UBE2I
ZBTB7B
ZNF219
Entrez ID
5440
30011
HPRD ID
05826
02301
Ensembl ID
ENSG00000147669
ENSG00000147010
Uniprot IDs
A0A024R9G0
P53803
B7Z6E8
Q5JPT6
Q96B97
PDB IDs
5IY6
5IY7
5IY8
5IY9
5IYA
5IYB
5IYC
5IYD
6DRD
6O9L
2BZ8
2K6D
2K9G
2N64
2O2O
2YDL
5ABS
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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