PMS2 and FANCC

Data Source:
BioGRID (two hybrid)

		PMS2	FANCC
Description		PMS1 homolog 2, mismatch repair system component	FA complementation group C
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Plasma Membrane Mismatch Repair Complex MutLalpha Complex Cytoplasmic Ribonucleoprotein Granule	Nucleus Nucleoplasm Cytoplasm Cytosol Fanconi Anaemia Nuclear Complex
	Molecular Function	DNA Binding Single-stranded DNA Binding Endonuclease Activity Protein Binding ATP Binding ATPase Activity Single Base Insertion Or Deletion Binding MutSalpha Complex Binding	Protein Binding
	Biological Process	Mismatch Repair Somatic Hypermutation Of Immunoglobulin Genes Response To Drug Nucleic Acid Phosphodiester Bond Hydrolysis	Myeloid Cell Homeostasis DNA Repair Nucleotide-excision Repair Germ Cell Development Removal Of Superoxide Radicals Cellular Response To Oxidative Stress Interstrand Cross-link Repair Brain Morphogenesis Protein-containing Complex Assembly Neuronal Stem Cell Population Maintenance
Pathways		Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Defective Mismatch Repair Associated With MLH1 Defective Mismatch Repair Associated With PMS2 TP53 Regulates Transcription of DNA Repair Genes	Fanconi Anemia Pathway TP53 Regulates Transcription of DNA Repair Genes
Drugs		Adenosine 5'-[gamma-thio]triphosphate
Diseases		Mismatch repair deficiency, including: Hereditary non-polyposis colorectal cancer (HNPCC); Lynch syndrome; Muir-Torre syndrome; Turcot syndrome	Fanconi anemia
GWAS			Birth weight ( 31043758) Hematocrit ( 32888494) Offspring birth weight ( 31043758) Polycystic ovary syndrome ( 26284813)
Interacting Genes		16 interacting genes: AKT1 ANP32B CCDC180 EXO1 FANCC GALNT12 MEOX2 MLH1 PCNA PPP2CB RASA1 SFRP4 TRMO UBC XPA ZNF189	54 interacting genes: APC AZIN1 BMPR1A BUB1 CAPN10 CCNA2 CCND1 CDK1 CTBP1 DLC1 DNAJB1 EGFR FANCA FANCD2 FANCE FANCF FANCG FBXW7 GSTP1 HSP90AA1 HSP90B1 HSPA1A HSPA4 HSPA8 IK KRAS KRT1 MEOX2 MLH3 MT-ATP6 MUTYH NRAS PDGFRL PIK3CA PMS2 POR PRDX3 PRPF31 PTPN12 PTPRJ RB1 RPL18 RPS3A SMAD4 SPTA1 SPTAN1 SRC STAT1 STMN1 STMN2 TCERG1 TGFBR2 USP14 ZBTB32
Entrez ID		5395	2176
HPRD ID		02598	01967
Ensembl ID		ENSG00000122512	ENSG00000158169
Uniprot IDs		A0A2R8Y6S3 B4DGM0 C9J167 P54278 Q7Z3Q2	A0A024R9N2 A0A087WW44 B4E3W2 Q00597
PDB IDs		1EA6 1H7S 1H7U 5U5R 6MFQ
Enriched GO Terms of Interacting Partners?
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