PMS2 and ZNF189

Data Source:
BioGRID (two hybrid)

		PMS2	ZNF189
Description		PMS1 homolog 2, mismatch repair system component	zinc finger protein 189
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Plasma Membrane Mismatch Repair Complex MutLalpha Complex Cytoplasmic Ribonucleoprotein Granule	Nucleus
	Molecular Function	DNA Binding Single-stranded DNA Binding Endonuclease Activity Protein Binding ATP Binding ATPase Activity Single Base Insertion Or Deletion Binding MutSalpha Complex Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Metal Ion Binding
	Biological Process	Mismatch Repair Somatic Hypermutation Of Immunoglobulin Genes Response To Drug Nucleic Acid Phosphodiester Bond Hydrolysis	Regulation Of Transcription By RNA Polymerase II
Pathways		Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Defective Mismatch Repair Associated With MLH1 Defective Mismatch Repair Associated With PMS2 TP53 Regulates Transcription of DNA Repair Genes	Generic Transcription Pathway
Drugs		Adenosine 5'-[gamma-thio]triphosphate
Diseases		Mismatch repair deficiency, including: Hereditary non-polyposis colorectal cancer (HNPCC); Lynch syndrome; Muir-Torre syndrome; Turcot syndrome
GWAS
Interacting Genes		16 interacting genes: AKT1 ANP32B CCDC180 EXO1 FANCC GALNT12 MEOX2 MLH1 PCNA PPP2CB RASA1 SFRP4 TRMO UBC XPA ZNF189	14 interacting genes: AURKA AXIN2 BMPR1A BRAF BUB1 CTNNA1 DLC1 ERBB2 KRAS MCC PMS2 SMAD4 SRC STK11
Entrez ID		5395	7743
HPRD ID		02598	11930
Ensembl ID		ENSG00000122512	ENSG00000136870
Uniprot IDs		A0A2R8Y6S3 B4DGM0 C9J167 P54278 Q7Z3Q2	A0A087X0K2 B7ZLK9 O75820
PDB IDs		1EA6 1H7S 1H7U 5U5R 6MFQ
Enriched GO Terms of Interacting Partners?
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