PMP22 and CLEC14A

Data Source:
BioGRID (two hybrid)

		PMP22	CLEC14A
Description		peripheral myelin protein 22	C-type lectin domain containing 14A
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane Synapse	External Side Of Plasma Membrane Integral Component Of Membrane Collagen-containing Extracellular Matrix
	Molecular Function	Protein Binding	Protein Binding Carbohydrate Binding Extracellular Matrix Binding Extracellular Matrix Protein Binding
	Biological Process	Chemical Synaptic Transmission Peripheral Nervous System Development Cell Death Bleb Assembly Myelin Assembly	Lymphangiogenesis Cell Migration Involved In Sprouting Angiogenesis Cell Migration Vascular Endothelial Growth Factor Receptor-2 Signaling Pathway Vascular Endothelial Growth Factor Receptor-3 Signaling Pathway
Pathways		EGR2 and SOX10-mediated initiation of Schwann cell myelination
Drugs			Resveratrol
Diseases		Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
GWAS		Allergic rhinitis ( 25085501) Amyotrophic lateral sclerosis ( 29566793) Corneal structure ( 23291589) Metabolite levels ( 23823483) Night sleep phenotypes ( 27126917) Preterm birth (maternal effect) ( 28877031) Resting heart rate ( 27798624)	Metabolite levels (5-HIAA/ MHPG Ratio) ( 23319000) Type 2 diabetes ( 30297969 32499647) Type 2 diabetes (age of onset) ( 28060188)
Interacting Genes		59 interacting genes: APOL3 ARL13B ASGR2 ATP6AP2 C16orf54 CANX CD3G CD53 CD69 CEACAM3 CLDN18 CLDN5 CLDN6 CLEC12B CLEC14A CREB3 CREB3L1 DDX52 EBP EDA EMP1 ERGIC3 FAM209A FCGRT FFAR2 GJA8 GPR42 GPR61 GPRC5D IFNGR2 KCNJ6 KCNN4 KLRC1 LMNA MPZ MS4A7 OPRM1 PDZK1IP1 PEX19 PGRMC2 REEP4 SCN3B SDC4 SHISAL1 SLC18A1 SLC38A1 SMIM3 SPACA1 STOM SYT2 TLCD4 TM4SF18 TM4SF19 TMEM139 TMEM14B TMEM30B TMEM31 TMX1 TSPAN12	13 interacting genes: ATP6V0C CLDN19 CLDN4 CYB561D2 EMD LHFPL5 MALL MGST2 MS4A1 PMP22 TMEM243 TSPAN2 VAMP3
Entrez ID		5376	161198
HPRD ID		03059	10711
Ensembl ID		ENSG00000109099	ENSG00000176435
Uniprot IDs		A8MU75 Q01453 Q6FH25	Q86T13
PDB IDs
Enriched GO Terms of Interacting Partners?
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