PMP22 and DDX52

Data Source:
BioGRID (two hybrid)

		PMP22	DDX52
Description		peripheral myelin protein 22	DExD-box helicase 52
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane Synapse	Nucleoplasm Nucleolus Membrane
	Molecular Function	Protein Binding	RNA Binding RNA Helicase Activity ATP Binding
	Biological Process	Chemical Synaptic Transmission Peripheral Nervous System Development Cell Death Bleb Assembly Myelin Assembly	RRNA Processing Maturation Of SSU-rRNA
Pathways		EGR2 and SOX10-mediated initiation of Schwann cell myelination	rRNA modification in the nucleus and cytosol Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases		Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
GWAS		Allergic rhinitis ( 25085501) Amyotrophic lateral sclerosis ( 29566793) Corneal structure ( 23291589) Metabolite levels ( 23823483) Night sleep phenotypes ( 27126917) Preterm birth (maternal effect) ( 28877031) Resting heart rate ( 27798624)	Ovarian cancer ( 23535730)
Interacting Genes		59 interacting genes: APOL3 ARL13B ASGR2 ATP6AP2 C16orf54 CANX CD3G CD53 CD69 CEACAM3 CLDN18 CLDN5 CLDN6 CLEC12B CLEC14A CREB3 CREB3L1 DDX52 EBP EDA EMP1 ERGIC3 FAM209A FCGRT FFAR2 GJA8 GPR42 GPR61 GPRC5D IFNGR2 KCNJ6 KCNN4 KLRC1 LMNA MPZ MS4A7 OPRM1 PDZK1IP1 PEX19 PGRMC2 REEP4 SCN3B SDC4 SHISAL1 SLC18A1 SLC38A1 SMIM3 SPACA1 STOM SYT2 TLCD4 TM4SF18 TM4SF19 TMEM139 TMEM14B TMEM30B TMEM31 TMX1 TSPAN12	5 interacting genes: AP4M1 HLCS MTNR1A PMP22 UTP23
Entrez ID		5376	11056
HPRD ID		03059	09911
Ensembl ID		ENSG00000109099	ENSG00000278053
Uniprot IDs		A8MU75 Q01453 Q6FH25	B3KM65 Q9Y2R4
PDB IDs			3DKP
Enriched GO Terms of Interacting Partners?
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