PLRG1 and MIR205

Data Source:
BioGRID (unspecified method)

		PLRG1	MIR205
Description		pleiotropic regulator 1	microRNA 205
Image			No pdb structure
GO Annotations	Cellular Component	Prp19 Complex Fibrillar Center Nucleus Nucleoplasm DNA Replication Factor A Complex Nuclear Speck Nuclear Membrane U2-type Catalytic Step 2 Spliceosome Catalytic Step 2 Spliceosome Cul4-RING E3 Ubiquitin Ligase Complex	Extracellular Space
	Molecular Function	Protein Binding	MRNA 3'-UTR Binding MRNA Binding Involved In Posttranscriptional Gene Silencing
	Biological Process	MRNA Splicing, Via Spliceosome Protein Localization To Nucleus Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle	Gene Silencing By MiRNA MiRNA Mediated Inhibition Of Translation Negative Regulation Of Receptor-mediated Endocytosis Negative Regulation Of Inflammatory Response Negative Regulation Of Fibroblast Growth Factor Production Regulation Of Aorta Morphogenesis Negative Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of Metalloendopeptidase Activity
Pathways		mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Fibrinogen ( 21757653) Fibrinogen levels ( 29403010 28107422)
Interacting Genes		14 interacting genes: APP CDC5L CNN1 HNRNPM MIR106B MIR205 MIR93 MIRLET7A2 MIRLET7E MIRLET7G MIRLET7I MX1 SF3B1 ZSCAN1	92 interacting genes: AIMP1 AIMP2 APOBEC3B AQR ATXN2L C1QBP CELF1 CELF2 CPSF1 DARS1 DDX1 DDX21 DDX3X DHX36 DHX37 EDC4 EIF2AK2 EPRS1 FAM98A FAM98B FIP1L1 FUS G3BP2 GRSF1 HNRNPA0 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPF HNRNPH1 HNRNPH2 HNRNPH3 HNRNPK HNRNPL HNRNPM HNRNPR IARS1 IGF2BP1 IGF2BP2 IGF2BP3 KARS1 KNOP1 LARP7 LARS1 LIN28A LIN28B LRPPRC MARS1 MATR3 MSI2 NOL6 NONO NUDT21 NUFIP2 PDCD11 PGAM5 PLRG1 PTBP1 PTBP3 PTCD3 PUF60 PURA QARS1 RARS1 RBFOX2 RBM14 RBM4 RBM45 RBMS1 RBMS2 RTCA RTCB SF3B1 SF3B2 SF3B3 SF3B4 SFPQ SPOUT1 SUGP2 SYNCRIP TAF15 TRA2A TRA2B TRIM25 U2SURP UPF1 UTP20 YBX1 YBX2 YBX3 ZC3H7B ZNF346
Entrez ID		5356	406988
HPRD ID		16181
Ensembl ID		ENSG00000171566	ENSG00000284485
Uniprot IDs		O43660
PDB IDs		4YVD 5MQF 5XJC 5YZG 5Z56 5Z57 5Z58 6FF4 6FF7 6ICZ 6ID0 6ID1 6QDV 6ZYM
Enriched GO Terms of Interacting Partners?
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