PLRG1 and MX1

Data Source:
BioGRID (two hybrid)

		PLRG1	MX1
Description		pleiotropic regulator 1	MX dynamin like GTPase 1
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GO Annotations	Cellular Component	Prp19 Complex Fibrillar Center Nucleus Nucleoplasm DNA Replication Factor A Complex Nuclear Speck Nuclear Membrane U2-type Catalytic Step 2 Spliceosome Catalytic Step 2 Spliceosome Cul4-RING E3 Ubiquitin Ligase Complex	Nucleus Cytoplasm Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Postsynaptic Density Microtubule Cytoskeleton Membrane Axon Cytoplasmic Vesicle Nuclear Membrane Mitochondrial Membrane Dendritic Spine Head Perinuclear Region Of Cytoplasm Presynapse Postsynaptic Endocytic Zone Membrane
	Molecular Function	Protein Binding	GTPase Activity Protein Binding GTP Binding Microtubule Binding Identical Protein Binding
	Biological Process	MRNA Splicing, Via Spliceosome Protein Localization To Nucleus Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle	Mitochondrial Fission Dynamin Family Protein Polymerization Involved In Mitochondrial Fission Apoptotic Process Defense Response Signal Transduction Response To Virus Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Receptor Internalization Response To Type I Interferon Negative Regulation Of Viral Genome Replication Innate Immune Response Regulation Of Synapse Structure Or Activity Defense Response To Virus Type I Interferon Signaling Pathway Membrane Fusion Postsynaptic Neurotransmitter Receptor Internalization
Pathways		mRNA Splicing - Major Pathway	ISG15 antiviral mechanism Interferon alpha/beta signaling
Drugs
Diseases
GWAS		Fibrinogen ( 21757653) Fibrinogen levels ( 29403010 28107422)
Interacting Genes		14 interacting genes: APP CDC5L CNN1 HNRNPM MIR106B MIR205 MIR93 MIRLET7A2 MIRLET7E MIRLET7G MIRLET7I MX1 SF3B1 ZSCAN1	41 interacting genes: ACTB ADRM1 APP BLM BRD7 C7orf25 CAB39L CASP8AP2 CBX4 CHD3 DAXX EPM2AIP1 FANCA GMEB1 HMGXB4 KIF26B KLHL35 LRRC4B MCCD1 PIAS1 PIAS2 PLRG1 PSD3 RELA SIAH1 SIRPA SLC25A3 SP100 TDG TRPC1 TRPC3 TRPC4 TRPC5 TRPC6 TRPC7 TUBA1A TUBB ZBTB16 ZCCHC12 ZNF251 ZNF623
Entrez ID		5356	4599
HPRD ID		16181	00919
Ensembl ID		ENSG00000171566	ENSG00000157601
Uniprot IDs		O43660	P20591
PDB IDs		4YVD 5MQF 5XJC 5YZG 5Z56 5Z57 5Z58 6FF4 6FF7 6ICZ 6ID0 6ID1 6QDV 6ZYM	3LJB 3SZR 3ZYS 4P4S 4P4T 4P4U 5GTM
Enriched GO Terms of Interacting Partners?
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