PKN3 and PLD1

Data Source:
HPRD (in vivo, in vitro)

		PKN3	PLD1
Description		protein kinase N3	phospholipase D1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Golgi Apparatus Perinuclear Region Of Cytoplasm	Golgi Membrane Lysosomal Membrane Endosome Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Membrane Apical Plasma Membrane Endocytic Vesicle Late Endosome Membrane Specific Granule Membrane Perinuclear Region Of Cytoplasm Tertiary Granule Membrane Cholinergic Synapse
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Calcium-dependent Protein Kinase C Activity Protein Binding ATP Binding	Phospholipase D Activity Protein Binding Phosphatidylinositol Binding N-acylphosphatidylethanolamine-specific Phospholipase D Activity
	Biological Process	Protein Phosphorylation Signal Transduction Epithelial Cell Migration Peptidyl-serine Phosphorylation Intracellular Signal Transduction	Phosphatidic Acid Biosynthetic Process Chemotaxis Small GTPase Mediated Signal Transduction Ras Protein Signal Transduction Lipid Catabolic Process Regulation Of Microvillus Assembly Neutrophil Degranulation Positive Regulation Of Translation Inositol Lipid-mediated Signaling Cell Motility Regulation Of Synaptic Vesicle Cycle
Pathways		RHO GTPases activate PKNs	Synthesis of PG Synthesis of PA Role of phospholipids in phagocytosis Neutrophil degranulation
Drugs			Choline LAX-101 Choline salicylate
Diseases
GWAS		Apolipoprotein B levels ( 32203549) Asthma ( 31361310) Axial length ( 24144296) Body mass index ( 26426971) Eating disorders (purging via substances) ( 23568457) Gamma glutamyl transferase levels ( 29403010) LDL cholesterol levels ( 32203549) Low density lipoprotein cholesterol levels ( 32154731) Neutrophil count ( 32888494) Obesity-related traits ( 23251661) Platelet count ( 32888494) Plateletcrit ( 32888494 27863252) White blood cell count ( 32888494)	Cerebrospinal fluid AB1-42 levels ( 29274321) Eosinophil counts ( 32888494) Red cell distribution width ( 32888494 27863252 28957414) Reticulocyte fraction of red cells ( 32888494)
Interacting Genes		9 interacting genes: ARHGAP10 ARHGAP26 GOLGA2 KRT31 MTUS2 PLD1 PNMA1 TFIP11 VPS52	26 interacting genes: ACTA1 ACTB ACTG1 ARF1 ARF6 ARIH1 BIN1 CAV1 CDC42 EGFR EGLN1 HIF1A PEA15 PIP5K1A PKN1 PKN3 PRKCA RAC1 RALA RHEB RHOA RHOG SNCA SRC STXBP1 VHL
Entrez ID		29941	5337
HPRD ID		17856	03855
Ensembl ID		ENSG00000160447	ENSG00000075651
Uniprot IDs		A0A024R8D6 Q6P5Z2	Q13393 Q59EA4
PDB IDs			6U8Z
Enriched GO Terms of Interacting Partners?
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