TRPC3 and STX3

Data Source:
HPRD (in vivo)

		TRPC3	STX3
Description		transient receptor potential cation channel subfamily C member 3	syntaxin 3
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Cation Channel Complex	Vacuole Plasma Membrane Cell-cell Junction Synaptic Vesicle Endomembrane System Integral Component Of Membrane Apical Plasma Membrane Lamellipodium Dendrite Growth Cone SNARE Complex Melanosome Specific Granule Azurophil Granule Zymogen Granule Membrane Neuron Projection Presynaptic Active Zone Membrane Extracellular Exosome Schaffer Collateral - CA1 Synapse Postsynapse Glutamatergic Synapse
	Molecular Function	Calcium Channel Activity Protein Binding Store-operated Calcium Channel Activity Inositol 1,4,5 Trisphosphate Binding	SNARE Binding SNAP Receptor Activity Protein Binding Arachidonic Acid Binding
	Biological Process	Calcium Ion Transport Manganese Ion Transport Single Fertilization Phototransduction Positive Regulation Of Calcium Ion Transport Into Cytosol Platelet Activation Response To ATP Regulation Of Cytosolic Calcium Ion Concentration Response To Calcium Ion Calcium Ion Transmembrane Transport Positive Regulation Of Cardiac Muscle Hypertrophy In Response To Stress	Intracellular Protein Transport Exocytosis Vesicle Fusion Positive Regulation Of Cell Population Proliferation Synaptic Vesicle Docking Cytokine-mediated Signaling Pathway Neuron Projection Development Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Positive Regulation Of Cell Adhesion Vesicle Docking Positive Regulation Of Chemotaxis Long-term Synaptic Potentiation Exocytic Insertion Of Neurotransmitter Receptor To Postsynaptic Membrane Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Protein Localization To Cell Surface
Pathways		Effects of PIP2 hydrolysis Elevation of cytosolic Ca2+ levels TRP channels Role of second messengers in netrin-1 signaling MECP2 regulates neuronal receptors and channels	Other interleukin signaling
Drugs
Diseases
GWAS		Asthma ( 31959851) Celiac disease and Rheumatoid arthritis ( 26546613) Emphysema imaging phenotypes ( 26030696) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Rosacea symptom severity ( 29771307)	High chromosomal aberration frequency (chromosome type) ( 31586183)
Interacting Genes		20 interacting genes: CALM1 FKBP1A GNA11 ITPR1 ITPR3 MX1 NAPA ORAI1 PLCB1 PLCB2 PLCB3 PLCG1 PRKCA PRKG1 SLC8A1 STX3 TRPC1 TRPC6 TRPC7 VAMP2	52 interacting genes: AQP6 CD79A COQ9 CPLX2 CPLX4 CREB3L1 CYB561 DNAJC5 EBAG9 ELOVL4 ERGIC3 EVI5 FAM209A FXYD3 GPR152 GPX8 JAGN1 LMNA MANBAL MFSD14B MGST3 MMGT1 MSMO1 MTIF3 NAPB PGRMC2 REEP4 RMDN3 SCN3B SLC35C2 SNAP23 SNAP25 SNAP29 STX1A STX2 STX4 STX5 STXBP1 STXBP2 SYT1 SYT4 SYT7 TBC1D30 TMEM14B TMPPE TMX2 TRPC3 TXLNA VAMP3 VAMP7 VAMP8 ZDHHC15
Entrez ID		7222	6809
HPRD ID		15999	15985
Ensembl ID		ENSG00000138741	ENSG00000166900
Uniprot IDs		Q13507	Q13277 Q53YE2
PDB IDs		5ZBG 6CUD 6D7L 6DJS
Enriched GO Terms of Interacting Partners?
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