TRPC3 and SLC8A1

Data Source:
HPRD (in vitro, in vivo)

		TRPC3	SLC8A1
Description		transient receptor potential cation channel subfamily C member 3	solute carrier family 8 member A1
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Cation Channel Complex	Nucleoplasm Mitochondrion Microtubule Plasma Membrane Integral Component Of Plasma Membrane Postsynaptic Density Intercalated Disc Membrane Z Disc T-tubule Axon Dendrite Sarcolemma Neuronal Cell Body Dendritic Spine Dendritic Shaft Axon Terminus Synapse Cell Periphery Postsynapse Integral Component Of Postsynaptic Membrane
	Molecular Function	Calcium Channel Activity Protein Binding Store-operated Calcium Channel Activity Inositol 1,4,5 Trisphosphate Binding	Calcium:sodium Antiporter Activity Calcium Ion Binding Protein Binding Calmodulin Binding Cytoskeletal Protein Binding Cation:cation Antiporter Activity Ankyrin Binding Ion Channel Binding Ion Antiporter Activity Involved In Regulation Of Postsynaptic Membrane Potential Calcium:cation Antiporter Activity Involved In Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration
	Biological Process	Calcium Ion Transport Manganese Ion Transport Single Fertilization Phototransduction Positive Regulation Of Calcium Ion Transport Into Cytosol Platelet Activation Response To ATP Regulation Of Cytosolic Calcium Ion Concentration Response To Calcium Ion Calcium Ion Transmembrane Transport Positive Regulation Of Cardiac Muscle Hypertrophy In Response To Stress	Regulation Of The Force Of Heart Contraction Regulation Of Heart Rate Regulation Of Sodium Ion Transport Ion Transport Cellular Calcium Ion Homeostasis Cellular Sodium Ion Homeostasis Muscle Contraction Response To Nutrient Response To Glucose Regulation Of Gene Expression Regulation Of Cell Communication By Electrical Coupling Positive Regulation Of Fibroblast Migration Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Vascular Associated Smooth Muscle Contraction Telencephalon Development Metal Ion Transport Positive Regulation Of Bone Mineralization Response To ATP Sodium Ion Transmembrane Transport Response To Immobilization Stress Response To Muscle Stretch Sodium Ion Export Across Plasma Membrane Response To Drug Response To Hydrogen Peroxide Relaxation Of Smooth Muscle Negative Regulation Of Cytosolic Calcium Ion Concentration Cardiac Muscle Cell Development Calcium Ion Homeostasis Relaxation Of Cardiac Muscle Cardiac Muscle Contraction Cytosolic Calcium Ion Transport Calcium Ion Transport Into Cytosol Calcium Ion Import Calcium Ion Transmembrane Transport Cellular Response To Caffeine Cellular Response To CAMP Cellular Response To Hypoxia Negative Regulation Of Protein Serine/threonine Kinase Activity Membrane Depolarization During Cardiac Muscle Cell Action Potential Cell Communication By Electrical Coupling Involved In Cardiac Conduction Calcium Ion Import Across Plasma Membrane Sodium Ion Import Across Plasma Membrane Positive Regulation Of The Force Of Heart Contraction Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration Regulation Of Cardiac Conduction
Pathways		Effects of PIP2 hydrolysis Elevation of cytosolic Ca2+ levels TRP channels Role of second messengers in netrin-1 signaling MECP2 regulates neuronal receptors and channels	Reduction of cytosolic Ca++ levels Sodium/Calcium exchangers Ion homeostasis
Drugs			alpha-Linolenic acid Icosapent Dronedarone Caldaret
Diseases
GWAS		Asthma ( 31959851) Celiac disease and Rheumatoid arthritis ( 26546613) Emphysema imaging phenotypes ( 26030696) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Rosacea symptom severity ( 29771307)	Adult body size ( 32376654) Asthma ( 27611488) Chronotype ( 30696823) Diastolic blood pressure ( 28135244) Early spontaneous preterm birth ( 31194736) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic traits ( 32602732 25055868) Estimated glomerular filtration rate ( 31152163 31451708) Estimated glomerular filtration rate in non-diabetics ( 31451708) Fractional exhaled nitric oxide levels ( 25431337) Fractures ( 30158200 30598549) Hand grip strength ( 29691431 29313844) Heel bone mineral density ( 30598549 28869591) HIV-associated dementia ( 22628157) Immune response to measles-mumps-rubella vaccine ( 24811271) Lymphocyte percentage of white cells ( 32888494) Mitochondrial DNA levels ( 25240745) Neutrophil percentage of white cells ( 32888494) Obesity (early onset extreme) ( 23563609) Obesity-related traits ( 23251661) PR interval ( 29127183 32439900 25035420) Proportion of activated microglia (inferior temporal cortex) ( 30679421) QT interval ( 29213071 24952745 22726844) Refractive error ( 32231278) Serum immune biomarker levels ( 32066700) Systolic blood pressure ( 30578418) Tea consumption ( 31046077) Total body bone mineral density ( 29304378) TPE interval (resting) ( 32386560)
Interacting Genes		20 interacting genes: CALM1 FKBP1A GNA11 ITPR1 ITPR3 MX1 NAPA ORAI1 PLCB1 PLCB2 PLCB3 PLCG1 PRKCA PRKG1 SLC8A1 STX3 TRPC1 TRPC6 TRPC7 VAMP2	7 interacting genes: CAV3 FXYD1 PPP3CB TRPC3 YWHAB YWHAE YWHAQ
Entrez ID		7222	6546
HPRD ID		15999	01659
Ensembl ID		ENSG00000138741	ENSG00000183023
Uniprot IDs		Q13507	P32418 Q4QQH3
PDB IDs		5ZBG 6CUD 6D7L 6DJS
Enriched GO Terms of Interacting Partners?
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