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PLAT and BAG4
Data Source:
BioGRID
(affinity chromatography technology)
PLAT
BAG4
Description
plasminogen activator, tissue type
BAG cochaperone 4
Image
GO Annotations
Cellular Component
Extracellular Region
Extracellular Space
Cytoplasm
Cell Surface
Collagen-containing Extracellular Matrix
Extracellular Exosome
Nucleus
Cytoplasm
Cytosol
Plasma Membrane
Membrane
Molecular Function
Serine-type Endopeptidase Activity
Signaling Receptor Binding
Protein Binding
Phosphoprotein Binding
Adenyl-nucleotide Exchange Factor Activity
RNA Binding
Protein Binding
Heat Shock Protein Binding
Ubiquitin Protein Ligase Binding
Protein-containing Complex Binding
Chaperone Binding
Biological Process
Cellular Protein Modification Process
Proteolysis
Blood Coagulation
Smooth Muscle Cell Migration
Plasminogen Activation
Fibrinolysis
Negative Regulation Of Proteolysis
Platelet-derived Growth Factor Receptor Signaling Pathway
Protein Folding
Positive Regulation Of Fibroblast Migration
Positive Regulation Of Actin Filament Polymerization
Positive Regulation Of Peptidyl-serine Phosphorylation
Tumor Necrosis Factor-mediated Signaling Pathway
Negative Regulation Of Apoptotic Process
Positive Regulation Of Cell Adhesion
Protein Stabilization
Positive Regulation Of Stress Fiber Assembly
Positive Regulation Of Protein Kinase B Signaling
Cellular Response To Tumor Necrosis Factor
Cellular Response To Epidermal Growth Factor Stimulus
Protein Localization To Plasma Membrane
Negative Regulation Of MRNA Modification
Ruffle Assembly
Regulation Of Cellular Response To Heat
Negative Regulation Of Protein Targeting To Mitochondrion
Negative Regulation Of Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase Activity
Pathways
Signaling by PDGF
Dissolution of Fibrin Clot
Regulation of HSF1-mediated heat shock response
Signaling by FGFR1 in disease
TNF signaling
Signaling by plasma membrane FGFR1 fusions
Drugs
Aminocaproic acid
Iloprost
Human C1-esterase inhibitor
5-(DIMETHYLAMINO)-2-NAPHTHALENESULFONIC ACID
Dexibuprofen
Conestat alfa
Diseases
GWAS
Blood protein levels (
30072576
)
Plasma plasminogen activator levels (
24578379
)
Systemic lupus erythematosus (
28714469
)
Autism spectrum disorder or schizophrenia (
28540026
)
Schizophrenia (
28991256
29483656
)
Interacting Genes
27 interacting genes:
ANXA2
APP
CALR
CKAP4
CLEC3B
F10
FGA
FN1
GRIN1
HMGB1
KRT8
LAMA1
LAMA3
LRP1
LRP1B
MAPK1
MAPK3
MTDH
PDGFC
PLAU
PLG
SERPINA5
SERPINE1
SERPING1
SERPINI1
SPARC
VDAC1
117 interacting genes:
ABI2
ACOT7
ADAMTSL4
ALG13
APOBEC1
ARID5A
ATAD2
ATP23
BAP1
BCAS3
BCL2
BCL6B
BEX1
BLZF1
C3orf38
CASP2
CASZ1
CBFA2T2
CCL5
DDIT4L
DIRAS3
DZIP3
EFEMP1
EPSTI1
ERRFI1
FAM214B
FAM222B
FARS2
FTH1
FYN
GLCE
GPANK1
GPS2
GRAP2
HOXA1
HSPA1A
HSPA1B
HSPA1L
HSPA2
HSPA6
HSPA8
IL13RA2
IL24
IST1
ITIH5
KCTD6
KCTD7
KIF5B
KLK5
KLK7
KLK9
KRTAP13-1
KRTAP13-4
KRTAP4-12
KRTAP4-2
KRTAP4-4
KRTAP4-5
KRTAP6-3
LASP1
LRATD2
LYPD3
MAGED1
MEI4
MRC2
MTA3
MYOZ1
MYOZ3
MYPOP
NAT2
ODF1
ODF3L1
P4HA3
PDCD6
PDLIM2
PEF1
PGRMC2
PHF19
PLAC8
PPIL6
PPP1R32
PRDM14
PSMB5
PYCR3
RAMAC
RASL10B
RHOBTB2
RNF20
RPL22
RUNX1
SAMD4A
SAXO1
SCGB3A1
SH3RF2
SIAH1
SNRPB
SNRPC
SS18L1
SUOX
TBC1D3B
TBC1D3G
TBC1D7
TCL1B
TEKT5
TFAP2D
THRSP
TINAGL1
TLE5
TNFRSF1A
TNFRSF25
TRAPPC6A
TSG101
UNKL
USP22
VPS37C
ZBTB45
ZBTB5
ZIM2
Entrez ID
5327
9530
HPRD ID
01419
04861
Ensembl ID
ENSG00000104368
ENSG00000156735
Uniprot IDs
B4DN26
P00750
O95429
PDB IDs
1A5H
1BDA
1PK2
1PML
1RTF
1TPG
1TPK
1TPM
1TPN
5BRR
5ZLZ
1M62
1M7K
Enriched GO Terms of Interacting Partners
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