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PLAT and PPP2CB
Data Source:
BioGRID
(affinity chromatography technology)
PLAT
PPP2CB
Description
plasminogen activator, tissue type
protein phosphatase 2 catalytic subunit beta
Image
No pdb structure
GO Annotations
Cellular Component
Extracellular Region
Extracellular Space
Cytoplasm
Cell Surface
Collagen-containing Extracellular Matrix
Extracellular Exosome
Protein Phosphatase Type 2A Complex
Chromosome, Centromeric Region
Spindle Pole
Nucleus
Cytosol
Molecular Function
Serine-type Endopeptidase Activity
Signaling Receptor Binding
Protein Binding
Phosphoprotein Binding
Protein Serine/threonine Phosphatase Activity
Protein Binding
Protein C-terminus Binding
Metal Ion Binding
Tau Protein Binding
Protein Serine Phosphatase Activity
Protein Threonine Phosphatase Activity
Biological Process
Cellular Protein Modification Process
Proteolysis
Blood Coagulation
Smooth Muscle Cell Migration
Plasminogen Activation
Fibrinolysis
Negative Regulation Of Proteolysis
Platelet-derived Growth Factor Receptor Signaling Pathway
Protein Dephosphorylation
Apoptotic Mitochondrial Changes
Response To Lead Ion
Regulation Of Gene Expression
Response To Endoplasmic Reticulum Stress
Peptidyl-threonine Dephosphorylation
Response To Hydrogen Peroxide
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Ras Protein Signal Transduction
Response To Antibiotic
Peptidyl-serine Dephosphorylation
Positive Regulation Of Microtubule Binding
Pathways
Signaling by PDGF
Dissolution of Fibrin Clot
Inhibition of replication initiation of damaged DNA by RB1/E2F1
Spry regulation of FGF signaling
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Integration of energy metabolism
PP2A-mediated dephosphorylation of key metabolic factors
DARPP-32 events
Degradation of beta-catenin by the destruction complex
Beta-catenin phosphorylation cascade
ERK/MAPK targets
ERKs are inactivated
MASTL Facilitates Mitotic Progression
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
CTLA4 inhibitory signaling
Platelet sensitization by LDL
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Signaling by GSK3beta mutants
S33 mutants of beta-catenin aren't phosphorylated
S37 mutants of beta-catenin aren't phosphorylated
S45 mutants of beta-catenin aren't phosphorylated
T41 mutants of beta-catenin aren't phosphorylated
APC truncation mutants have impaired AXIN binding
AXIN missense mutants destabilize the destruction complex
Truncations of AMER1 destabilize the destruction complex
RHO GTPases Activate Formins
RAF activation
Negative regulation of MAPK pathway
Regulation of TP53 Degradation
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Mitotic Prometaphase
Cyclin D associated events in G1
Cyclin A/B1/B2 associated events during G2/M transition
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism
EML4 and NUDC in mitotic spindle formation
Drugs
Aminocaproic acid
Iloprost
Human C1-esterase inhibitor
5-(DIMETHYLAMINO)-2-NAPHTHALENESULFONIC ACID
Dexibuprofen
Conestat alfa
Vitamin E
Diseases
GWAS
Blood protein levels (
30072576
)
Plasma plasminogen activator levels (
24578379
)
Systemic lupus erythematosus (
28714469
)
Daytime sleep phenotypes (
27126917
)
Interacting Genes
27 interacting genes:
ANXA2
APP
CALR
CKAP4
CLEC3B
F10
FGA
FN1
GRIN1
HMGB1
KRT8
LAMA1
LAMA3
LRP1
LRP1B
MAPK1
MAPK3
MTDH
PDGFC
PLAU
PLG
SERPINA5
SERPINE1
SERPING1
SERPINI1
SPARC
VDAC1
41 interacting genes:
ACP5
AURKA
AXIN1
BHLHE41
BUB1
C22orf39
DOCK7
DYNLT2B
EGFR
GAD1
GSTA1
HK3
KRAS
LCMT1
MAK
MAPT
MID1
MLH1
MLH3
NRAS
PACS1
PDGFRL
PLXNA3
PMS2
PRKCB
PTPRJ
RAF1
RELA
RPLP1
SGO1
SMAD4
SRC
STK11
TAB1
TAB2
TGFBR2
TIPRL
TLX1
TRMT61B
ZFP28
ZNF775
Entrez ID
5327
5516
HPRD ID
01419
01487
Ensembl ID
ENSG00000104368
ENSG00000104695
Uniprot IDs
B4DN26
P00750
A0A140VJS0
P62714
PDB IDs
1A5H
1BDA
1PK2
1PML
1RTF
1TPG
1TPK
1TPM
1TPN
5BRR
5ZLZ
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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