PLAGL1 and KAT2B

Data Source:
BioGRID (pull down)

		PLAGL1	KAT2B
Description		PLAG1 like zinc finger 1	lysine acetyltransferase 2B
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Golgi Apparatus Nuclear Body Intracellular Membrane-bounded Organelle	PCAF Complex Kinetochore Nucleus Nucleoplasm Ada2/Gcn5/Ada3 Transcription Activator Complex Centrosome Cytosol A Band I Band Protein-containing Complex Actomyosin
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Metal Ion Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Chromatin Binding Transcription Coregulator Activity Transcription Coactivator Activity Diamine N-acetyltransferase Activity Histone Acetyltransferase Activity Lysine N-acetyltransferase Activity, Acting On Acetyl Phosphate As Donor Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Protein Binding Transcription Factor Binding Acetyltransferase Activity Protein Kinase Binding Histone Deacetylase Binding Peptide-lysine-N-acetyltransferase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Apoptotic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Cell Cycle Arrest Positive Regulation Of Transcription By RNA Polymerase II	Chromatin Remodeling Transcription Initiation From RNA Polymerase II Promoter Protein Acetylation Cell Cycle Arrest Notch Signaling Pathway Positive Regulation Of Transcription Of Notch Receptor Target Heart Development Negative Regulation Of Cell Population Proliferation Regulation Of Protein ADP-ribosylation Viral Process Protein Deubiquitination N-terminal Peptidyl-lysine Acetylation Protein Phosphopantetheinylation Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation Cellular Response To Insulin Stimulus Histone H3 Acetylation Histone H3-K9 Acetylation Regulation Of Megakaryocyte Differentiation Positive Regulation Of Gluconeogenesis Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Notch Signaling Pathway Positive Regulation Of Gene Expression, Epigenetic Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Centriole Replication Rhythmic Process Limb Development Negative Regulation Of RRNA Processing
Pathways		TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	Pre-NOTCH Transcription and Translation Pre-NOTCH Transcription and Translation YAP1- and WWTR1 (TAZ)-stimulated gene expression Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells NOTCH1 Intracellular Domain Regulates Transcription NOTCH1 Intracellular Domain Regulates Transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants HATs acetylate histones Notch-HLH transcription pathway B-WICH complex positively regulates rRNA expression Physiological factors Metalloprotease DUBs RNA Polymerase I Transcription Initiation RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX3 regulates NOTCH signaling RUNX3 regulates NOTCH signaling NOTCH3 Intracellular Domain Regulates Transcription NOTCH3 Intracellular Domain Regulates Transcription NOTCH4 Intracellular Domain Regulates Transcription Estrogen-dependent gene expression Regulation of FOXO transcriptional activity by acetylation
Drugs			Coenzyme A (3E)-4-(1-METHYL-1H-INDOL-3-YL)BUT-3-EN-2-ONE N-(3-AMINOPROPYL)-2-NITROBENZENAMINE
Diseases		Transient neonatal diabetes mellitus (TNDM)
GWAS		Anti-saccade response ( 29064472) Eosinophil percentage of granulocytes ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) Lymphocyte percentage of white cells ( 32888494) Monocyte count ( 27863252) Monocyte percentage of white cells ( 32888494 27863252) Neutrophil percentage of granulocytes ( 27863252) Neutrophil percentage of white cells ( 32888494 27863252) Peanut allergy (maternal genetic effects) ( 29489655) Post bronchodilator FEV1/FVC ratio ( 26634245)	Drug abuse ( 26202629) High light scatter reticulocyte count ( 32888494) Mean arterial pressure (alcohol consumption interaction) ( 24376456) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular volume ( 29403010 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Optic disc size ( 31809533) Post-traumatic stress disorder ( 24677629) Red blood cell count ( 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Staphylococcus aureus nasal carriage (intermittent) ( 26569114) Systolic blood pressure ( 30224653 30578418)
Interacting Genes		11 interacting genes: CREBBP DAXX EP300 KAT2B PIAS2 PML SMAD3 SUMO1 TLE5 TP53 UBE2I	121 interacting genes: ACTN1 ACTN2 AKT1 AR ARHGDIA ARNTL ATF4 ATXN3 BRCA2 CCNA2 CCND1 CCNT1 CDC25B CDCA4 CDK2 CDKN1B CDT1 CEBPB CEP250 CIITA CLOCK CREBBP CTBP1 CTNNB1 CUX1 DACH2 DEK EP300 ESRRA ETV1 EZH2 GATAD2A GATAD2B H1-1 H1-5 H2AC20 H2AC4 H2BC21 H2BC3 H3-3A H3-4 H3C1 H3C14 H4-16 H4C1 HIPK2 HMGA1 HMGN2 HNF1A HNRNPU HOXB9 HSD11B2 HTT ING1 IRF1 IRF2 IRF7 JDP2 KLF10 KLF13 KLF2 LIN28B MAPK14 MAPRE1 MDM2 MECOM MYC MYOD1 NCOA1 NCOA3 NCOA4 NFATC1 NFE2 NFE4 NOTCH1 NOTCH3 NPAS2 NR1H3 NR4A1 NRIP1 ONECUT1 PARP1 PDK1 PGR PLAGL1 PNMA1 POLR2A PTF1A RAB11A RARA RB1 RBM8A RBPJ RELA RPS6KB1 RPS6KB2 SAT2 SATB1 SERBP1 SERTAD1 SERTAD2 SIRT2 SMAD1 SMAD2 SMAD3 SRCAP TACC2 TAL1 TCF3 TMF1 TP53 TP63 TP73 TRIM14 TTF1 TWIST1 UBE2D1 UBE2D2 UBE2D3 XRCC6 YY1
Entrez ID		5325	8850
HPRD ID		16010	06780
Ensembl ID		ENSG00000118495	ENSG00000114166
Uniprot IDs		A1YLA1 A1YLA2 Q9UM63	Q92831
PDB IDs			1CM0 1JM4 1N72 1WUG 1WUM 1ZS5 2RNW 2RNX 3GG3 4NSQ 5FDZ 5FE0 5FE1 5FE2 5FE3 5FE4 5FE5 5FE6 5FE7 5FE8 5FE9 5LVQ 5LVR 5MKX 6J3O
Enriched GO Terms of Interacting Partners?
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