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PIN1 and CCNB1
Data Source:
HPRD
(in vitro)
PIN1
CCNB1
Description
peptidylprolyl cis/trans isomerase, NIMA-interacting 1
cyclin B1
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Cytosol
Nuclear Speck
Midbody
Ciliary Basal Body
Neuron Projection
Glutamatergic Synapse
Postsynaptic Cytosol
Cyclin-dependent Protein Kinase Holoenzyme Complex
Spindle Pole
Condensed Nuclear Chromosome Outer Kinetochore
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrial Matrix
Centrosome
Cytosol
Membrane
Cyclin B1-CDK1 Complex
Molecular Function
Peptidyl-prolyl Cis-trans Isomerase Activity
Motor Activity
Protein Binding
Beta-catenin Binding
Cis-trans Isomerase Activity
Mitogen-activated Protein Kinase Kinase Binding
GTPase Activating Protein Binding
Tau Protein Binding
Phosphoserine Residue Binding
Phosphothreonine Residue Binding
Phosphoprotein Binding
Patched Binding
Protein Binding
Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity
Protein Kinase Binding
Ubiquitin-like Protein Ligase Binding
Cyclin-dependent Protein Serine/threonine Kinase Activator Activity
Biological Process
Protein Peptidyl-prolyl Isomerization
Response To Hypoxia
Regulation Of Protein Phosphorylation
Positive Regulation Of Protein Phosphorylation
Cell Cycle
Regulation Of Mitotic Nuclear Division
Regulation Of Gene Expression
Neuron Differentiation
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Regulation Of Protein Stability
Negative Regulation Of Protein Binding
Positive Regulation Of Protein Binding
Regulation Of Cytokinesis
Negative Regulation Of Type I Interferon Production
Positive Regulation Of Protein Dephosphorylation
Negative Regulation Of Protein Catabolic Process
Negative Regulation Of Neuron Apoptotic Process
Positive Regulation Of Neuron Apoptotic Process
Positive Regulation Of GTPase Activity
Positive Regulation Of Transcription By RNA Polymerase II
Microtubule Polymerization
Synapse Organization
Protein Stabilization
Positive Regulation Of Ubiquitin-protein Transferase Activity
Regulation Of Pathway-restricted SMAD Protein Phosphorylation
Positive Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development
Negative Regulation Of ERK1 And ERK2 Cascade
Positive Regulation Of Canonical Wnt Signaling Pathway
Regulation Of Protein Localization To Nucleus
Regulation Of Signal Transduction By P53 Class Mediator
Negative Regulation Of Amyloid-beta Formation
Negative Regulation Of Cell Motility
Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
G2/M Transition Of Mitotic Cell Cycle
Oocyte Maturation
In Utero Embryonic Development
Negative Regulation Of Protein Phosphorylation
Transcription Initiation From RNA Polymerase II Promoter
DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest
Mitotic Spindle Organization
Mitotic Nuclear Envelope Disassembly
Mitotic Metaphase Plate Congression
Spermatogenesis
Response To Mechanical Stimulus
Negative Regulation Of Gene Expression
Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle
Anaphase-promoting Complex-dependent Catabolic Process
Positive Regulation Of MRNA 3'-end Processing
Positive Regulation Of Histone Phosphorylation
Tissue Regeneration
Response To Drug
Mitotic Cell Cycle Phase Transition
Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Positive Regulation Of Mitotic Cell Cycle
Response To DDT
Positive Regulation Of Fibroblast Proliferation
Digestive Tract Development
Cell Division
Regulation Of Cell Cycle
Positive Regulation Of Attachment Of Spindle Microtubules To Kinetochore
Ventricular Cardiac Muscle Cell Development
Positive Regulation Of Cardiac Muscle Cell Proliferation
Regulation Of Chromosome Condensation
Protein-containing Complex Assembly
Cellular Response To Iron(III) Ion
Cellular Response To Fatty Acid
Cellular Response To Organic Cyclic Compound
Cellular Response To Hypoxia
Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint
Regulation Of Mitotic Cell Cycle Phase Transition
Positive Regulation Of Mitochondrial ATP Synthesis Coupled Electron Transport
Histone H3-S10 Phosphorylation Involved In Chromosome Condensation
Pathways
ISG15 antiviral mechanism
RHO GTPases Activate NADPH Oxidases
Regulation of TP53 Activity through Phosphorylation
PI5P Regulates TP53 Acetylation
Negative regulators of DDX58/IFIH1 signaling
E2F-enabled inhibition of pre-replication complex formation
Polo-like kinase mediated events
Golgi Cisternae Pericentriolar Stack Reorganization
APC/C:Cdc20 mediated degradation of Cyclin B
Regulation of APC/C activators between G1/S and early anaphase
Phosphorylation of the APC/C
Phosphorylation of Emi1
Condensation of Prophase Chromosomes
MASTL Facilitates Mitotic Progression
Resolution of Sister Chromatid Cohesion
Condensation of Prometaphase Chromosomes
Regulation of PLK1 Activity at G2/M Transition
Activation of NIMA Kinases NEK9, NEK6, NEK7
Initiation of Nuclear Envelope (NE) Reformation
Nuclear Pore Complex (NPC) Disassembly
Depolymerisation of the Nuclear Lamina
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
Mitotic Prophase
Cyclin A/B1/B2 associated events during G2/M transition
G2/M DNA replication checkpoint
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
The role of GTSE1 in G2/M progression after G2 checkpoint
Transcriptional regulation by RUNX2
Drugs
Beta-(2-Naphthyl)-Alanine
3,6,9,12,15,18-HEXAOXAICOSANE
Diseases
GWAS
Sleep duration (
25469926
)
Interacting Genes
263 interacting genes:
ABI2
ADAMTSL4
ADARB1
AJUBA
AMOT
ANKRD40
AP2A1
APLP1
APP
ARHGEF15
ARID5A
ATCAY
ATN1
ATP5F1B
BAG6
BARD1
BCL11A
BCL2
BCL6
BCLAF1
BRCA1
BRD8
C3orf36
CAPRIN1
CARHSP1
CASP6
CBFA2T3
CBS
CBY2
CCDC153
CCDC184
CCDC33
CCDC6
CCDC88B
CCDC90B
CCNB1
CCNE1
CCNK
CDC25C
CDC27
CDK1
CDK11A
CDK11B
CDK12
CDK2
CDK9
CDKN1B
CENPB
CEP55
CEP76
CHAMP1
CHPF
CNKSR1
COL11A2
CPEB1
CPNE6
CSAD
CSNK2A1
CSNK2A2
CSNK2B
CTNNB1
DAB1
DAB2
DDAH2
DDB1
DDX17
DDX24
DDX3X
DDX5
DEAF1
DHX15
DMPK
DYNC1I1
E2F4
EFS
EFTUD2
EIF3G
EP300
ETV6
EYA2
FAAP20
FADD
FASLG
FHL5
FOS
FOSL1
FOXI1
FOXN1
FOXO4
FOXP2
FRS2
FUCA2
G3BP1
G3BP2
GGA2
GLI1
GMEB2
GOLGA2
GOLGA6L9
GPAA1
GPHN
GPR152
HADHA
HEXIM2
HNRNPC
HNRNPH1
HNRNPK
HNRNPU
HOMEZ
HOXA1
IKZF1
IKZF3
INO80E
JAKMIP2
JUN
KCTD7
KIF20B
KIF5A
KIFC3
KLHL20
KMT2B
KRT31
KRT34
KRT37
KRT38
KRT40
KRTAP10-1
KRTAP10-3
KRTAP10-6
KRTAP10-7
KRTAP10-8
KRTAP10-9
KRTAP4-2
KRTAP5-9
LCN2
LEPR
LRIF1
MAP1S
MAP3K11
MAPT
MCL1
MDFI
MED1
MEOX1
MEOX2
MLLT6
MOCS1
MTFR1
MTUS2
MYF5
MYT1
NAB2
NCKIPSD
NCOA3
NCOR2
NEK6
NELFA
NEUROD4
NFATC2
NONO
NR4A3
NUP35
NUP62
PABPC1
PAX6
PBX1
PDLIM7
PKIB
PKM
PKMYT1
PLAGL2
PLEKHG2
PLK1
PML
PNMA1
POLR2A
PRPF8
PRRC1
PTOV1
PTPN1
QARS1
RAB4A
RAF1
RAI1
RARA
RBBP8
RBBP8NL
RBPMS
RELA
REPS1
RNF208
RNPS1
RPL4
RPS6KB1
SCAI
SCYL1
SELENOV
SFPQ
SGK1
SHKBP1
SMAD3
SNCAIP
SNRNP200
SOCS3
SREK1
SRRM1
SRRM2
SRSF11
SSBP2
SSBP3
SSBP4
SSC5D
STIL
SUPT5H
TAB3
TBC1D4
TCF12
TCF4
TFG
TFPT
THAP7
THRAP3
TLE3
TNIP1
TNS2
TOP2A
TOX3
TP53
TP63
TP73
TRAF1
TRAF2
TRIM27
TRIM59
TRIP6
TRMT2A
TSC2
TSC22D4
TUT1
U2AF2
UBB
UBQLN2
UBQLN4
UBXN2B
UNC119
VIRMA
WEE1
WIZ
WRNIP1
XRCC6
ZBTB14
ZBTB2
ZBTB22
ZBTB42
ZBTB7B
ZBTB9
ZCCHC10
ZMIZ2
ZNF446
ZNF449
ZNF526
ZNF768
ZNF783
59 interacting genes:
ANAPC11
ARID4A
BRCA1
CCNB1IP1
CCNF
CDC20
CDC25A
CDC25C
CDC27
CDC34
CDC6
CDK1
CDKN1A
CDKN1B
CDT1
EP300
FLNA
FZR1
GADD45A
GADD45B
GADD45G
H1-1
H1-5
HERC5
ITPR1
KAT5
MAP4
MEF2C
MOK
OTUD7B
PBK
PCNA
PIN1
PKMYT1
PLK1
POLA1
PRC1
PRKDC
PRKN
PTCH1
PTMA
RALBP1
RB1
RPA1
RUNX2
SQSTM1
TGFBR2
TP53BP1
TP73
TSC1
TSPYL2
TULP3
UBE2C
UBE2D2
UBE2N
UBE2S
UBE3C
UBE3D
XIAP
Entrez ID
5300
891
HPRD ID
03031
00454
Ensembl ID
ENSG00000127445
ENSG00000134057
Uniprot IDs
Q13526
P14635
PDB IDs
1F8A
1I6C
1I8G
1I8H
1NMV
1NMW
1PIN
1ZCN
2F21
2ITK
2KBU
2KCF
2LB3
2M8I
2M8J
2M9E
2M9F
2M9I
2M9J
2N1O
2Q5A
2RUC
2RUD
2RUQ
2RUR
2XP3
2XP4
2XP5
2XP6
2XP7
2XP8
2XP9
2XPA
2XPB
2ZQS
2ZQT
2ZQU
2ZQV
2ZR4
2ZR5
2ZR6
3I6C
3IK8
3IKD
3IKG
3JYJ
3KAB
3KAC
3KAD
3KAF
3KAG
3KAH
3KAI
3KCE
3NTP
3ODK
3OOB
3TC5
3TCZ
3TDB
3WH0
4GWT
4GWV
4QIB
4TNS
4TYO
4U84
4U85
4U86
5B3W
5B3X
5B3Y
5B3Z
5BMY
5GPH
5UY9
5VTI
5VTJ
5VTK
6DUN
6O33
6O34
6SVC
6SVE
6SVH
2B9R
2JGZ
4Y72
4YC3
5HQ0
5LQF
6GU2
6GU3
6GU4
Enriched GO Terms of Interacting Partners
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