Wiki-MPM
About
Search
Browse
People
Funding
Updates
Search
PIN1 and BRCA1
Data Source:
BioGRID
(pull down)
PIN1
BRCA1
Description
peptidylprolyl cis/trans isomerase, NIMA-interacting 1
BRCA1 DNA repair associated
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Cytosol
Nuclear Speck
Midbody
Ciliary Basal Body
Neuron Projection
Glutamatergic Synapse
Postsynaptic Cytosol
Ubiquitin Ligase Complex
Lateral Element
Nucleus
Nucleoplasm
Chromosome
Cytoplasm
Plasma Membrane
Gamma-tubulin Ring Complex
Nuclear Body
BRCA1-BARD1 Complex
Protein-containing Complex
BRCA1-A Complex
Ribonucleoprotein Complex
Molecular Function
Peptidyl-prolyl Cis-trans Isomerase Activity
Motor Activity
Protein Binding
Beta-catenin Binding
Cis-trans Isomerase Activity
Mitogen-activated Protein Kinase Kinase Binding
GTPase Activating Protein Binding
Tau Protein Binding
Phosphoserine Residue Binding
Phosphothreonine Residue Binding
Phosphoprotein Binding
Transcription Regulatory Region Sequence-specific DNA Binding
DNA Binding
Damaged DNA Binding
Transcription Coactivator Activity
RNA Binding
Ubiquitin-protein Transferase Activity
Protein Binding
Zinc Ion Binding
Tubulin Binding
Enzyme Binding
Ubiquitin Protein Ligase Binding
Identical Protein Binding
RNA Polymerase Binding
Biological Process
Protein Peptidyl-prolyl Isomerization
Response To Hypoxia
Regulation Of Protein Phosphorylation
Positive Regulation Of Protein Phosphorylation
Cell Cycle
Regulation Of Mitotic Nuclear Division
Regulation Of Gene Expression
Neuron Differentiation
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Regulation Of Protein Stability
Negative Regulation Of Protein Binding
Positive Regulation Of Protein Binding
Regulation Of Cytokinesis
Negative Regulation Of Type I Interferon Production
Positive Regulation Of Protein Dephosphorylation
Negative Regulation Of Protein Catabolic Process
Negative Regulation Of Neuron Apoptotic Process
Positive Regulation Of Neuron Apoptotic Process
Positive Regulation Of GTPase Activity
Positive Regulation Of Transcription By RNA Polymerase II
Microtubule Polymerization
Synapse Organization
Protein Stabilization
Positive Regulation Of Ubiquitin-protein Transferase Activity
Regulation Of Pathway-restricted SMAD Protein Phosphorylation
Positive Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development
Negative Regulation Of ERK1 And ERK2 Cascade
Positive Regulation Of Canonical Wnt Signaling Pathway
Regulation Of Protein Localization To Nucleus
Regulation Of Signal Transduction By P53 Class Mediator
Negative Regulation Of Amyloid-beta Formation
Negative Regulation Of Cell Motility
Double-strand Break Repair Via Homologous Recombination
DNA Double-strand Break Processing
DNA Replication
Postreplication Repair
Double-strand Break Repair
Double-strand Break Repair Via Nonhomologous End Joining
Regulation Of Gene Expression By Genetic Imprinting
Regulation Of Transcription By RNA Polymerase II
Regulation Of Transcription By RNA Polymerase III
Fatty Acid Biosynthetic Process
Apoptotic Process
Cellular Response To DNA Damage Stimulus
DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator
Chromosome Segregation
Centrosome Cycle
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Dosage Compensation By Inactivation Of X Chromosome
Response To Ionizing Radiation
Positive Regulation Of Vascular Endothelial Growth Factor Production
Positive Regulation Of Gene Expression
Protein Ubiquitination
Protein Deubiquitination
Positive Regulation Of Protein Ubiquitination
Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway
Positive Regulation Of Histone Acetylation
Negative Regulation Of Histone Acetylation
Regulation Of Cell Population Proliferation
Regulation Of Apoptotic Process
Chordate Embryonic Development
Response To Estrogen
Regulation Of DNA Methylation
Mitotic G2/M Transition Checkpoint
Negative Regulation Of Fatty Acid Biosynthetic Process
Positive Regulation Of DNA Repair
Positive Regulation Of Angiogenesis
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Centriole Replication
Positive Regulation Of Histone H3-K4 Methylation
Negative Regulation Of Histone H3-K4 Methylation
Negative Regulation Of Histone H3-K9 Methylation
Positive Regulation Of Histone H3-K9 Methylation
Protein Autoubiquitination
Negative Regulation Of G0 To G1 Transition
Positive Regulation Of Histone H4-K20 Methylation
Positive Regulation Of Cell Cycle Arrest
Cellular Response To Tumor Necrosis Factor
Cellular Response To Indole-3-methanol
Signal Transduction Involved In G2 DNA Damage Checkpoint
Protein K6-linked Ubiquitination
Regulation Of Signal Transduction By P53 Class Mediator
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Negative Regulation Of Reactive Oxygen Species Metabolic Process
Positive Regulation Of Histone H3-K9 Acetylation
Positive Regulation Of Histone H4-K16 Acetylation
Pathways
ISG15 antiviral mechanism
RHO GTPases Activate NADPH Oxidases
Regulation of TP53 Activity through Phosphorylation
PI5P Regulates TP53 Acetylation
Negative regulators of DDX58/IFIH1 signaling
Meiotic synapsis
SUMOylation of DNA damage response and repair proteins
HDR through Single Strand Annealing (SSA)
HDR through Homologous Recombination (HRR)
Metalloprotease DUBs
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Resolution of D-loop Structures through Holliday Junction Intermediates
Nonhomologous End-Joining (NHEJ)
Homologous DNA Pairing and Strand Exchange
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange
TP53 Regulates Transcription of DNA Repair Genes
Regulation of TP53 Activity through Phosphorylation
G2/M DNA damage checkpoint
Transcriptional Regulation by E2F6
Meiotic recombination
Defective DNA double strand break response due to BRCA1 loss of function
Defective DNA double strand break response due to BARD1 loss of function
Drugs
Beta-(2-Naphthyl)-Alanine
3,6,9,12,15,18-HEXAOXAICOSANE
Diseases
Breast cancer
Ovarian cancer
GWAS
Sleep duration (
25469926
)
Gynecologic disease (multivariate analysis) (
31488892
)
Menopause (age at onset) (
26414677
29773799
)
Monocyte percentage of white cells (
32888494
)
Ovarian cancer (
31488892
)
Ovarian cancer (MTAG) (
31488892
)
Interacting Genes
263 interacting genes:
ABI2
ADAMTSL4
ADARB1
AJUBA
AMOT
ANKRD40
AP2A1
APLP1
APP
ARHGEF15
ARID5A
ATCAY
ATN1
ATP5F1B
BAG6
BARD1
BCL11A
BCL2
BCL6
BCLAF1
BRCA1
BRD8
C3orf36
CAPRIN1
CARHSP1
CASP6
CBFA2T3
CBS
CBY2
CCDC153
CCDC184
CCDC33
CCDC6
CCDC88B
CCDC90B
CCNB1
CCNE1
CCNK
CDC25C
CDC27
CDK1
CDK11A
CDK11B
CDK12
CDK2
CDK9
CDKN1B
CENPB
CEP55
CEP76
CHAMP1
CHPF
CNKSR1
COL11A2
CPEB1
CPNE6
CSAD
CSNK2A1
CSNK2A2
CSNK2B
CTNNB1
DAB1
DAB2
DDAH2
DDB1
DDX17
DDX24
DDX3X
DDX5
DEAF1
DHX15
DMPK
DYNC1I1
E2F4
EFS
EFTUD2
EIF3G
EP300
ETV6
EYA2
FAAP20
FADD
FASLG
FHL5
FOS
FOSL1
FOXI1
FOXN1
FOXO4
FOXP2
FRS2
FUCA2
G3BP1
G3BP2
GGA2
GLI1
GMEB2
GOLGA2
GOLGA6L9
GPAA1
GPHN
GPR152
HADHA
HEXIM2
HNRNPC
HNRNPH1
HNRNPK
HNRNPU
HOMEZ
HOXA1
IKZF1
IKZF3
INO80E
JAKMIP2
JUN
KCTD7
KIF20B
KIF5A
KIFC3
KLHL20
KMT2B
KRT31
KRT34
KRT37
KRT38
KRT40
KRTAP10-1
KRTAP10-3
KRTAP10-6
KRTAP10-7
KRTAP10-8
KRTAP10-9
KRTAP4-2
KRTAP5-9
LCN2
LEPR
LRIF1
MAP1S
MAP3K11
MAPT
MCL1
MDFI
MED1
MEOX1
MEOX2
MLLT6
MOCS1
MTFR1
MTUS2
MYF5
MYT1
NAB2
NCKIPSD
NCOA3
NCOR2
NEK6
NELFA
NEUROD4
NFATC2
NONO
NR4A3
NUP35
NUP62
PABPC1
PAX6
PBX1
PDLIM7
PKIB
PKM
PKMYT1
PLAGL2
PLEKHG2
PLK1
PML
PNMA1
POLR2A
PRPF8
PRRC1
PTOV1
PTPN1
QARS1
RAB4A
RAF1
RAI1
RARA
RBBP8
RBBP8NL
RBPMS
RELA
REPS1
RNF208
RNPS1
RPL4
RPS6KB1
SCAI
SCYL1
SELENOV
SFPQ
SGK1
SHKBP1
SMAD3
SNCAIP
SNRNP200
SOCS3
SREK1
SRRM1
SRRM2
SRSF11
SSBP2
SSBP3
SSBP4
SSC5D
STIL
SUPT5H
TAB3
TBC1D4
TCF12
TCF4
TFG
TFPT
THAP7
THRAP3
TLE3
TNIP1
TNS2
TOP2A
TOX3
TP53
TP63
TP73
TRAF1
TRAF2
TRIM27
TRIM59
TRIP6
TRMT2A
TSC2
TSC22D4
TUT1
U2AF2
UBB
UBQLN2
UBQLN4
UBXN2B
UNC119
VIRMA
WEE1
WIZ
WRNIP1
XRCC6
ZBTB14
ZBTB2
ZBTB22
ZBTB42
ZBTB7B
ZBTB9
ZCCHC10
ZMIZ2
ZNF446
ZNF449
ZNF526
ZNF768
ZNF783
318 interacting genes:
ABL1
ABLIM3
ABRAXAS1
ACACA
ACTG1
ACTN3
AHR
AKT1
ALDH1A1
ANKRD28
ANTXR1
AP1M1
APLP2
AR
ARNT
ASH2L
ATF1
ATM
ATP1B1
ATP1B3
ATR
ATRIP
AURKA
AURKC
BABAM1
BAP1
BARD1
BRAP
BRAT1
BRCA2
BRCC3
BRIP1
BRSK1
C2CD6
CABYR
CASP3
CBX1
CBX5
CCDC120
CCNA1
CCNA2
CCNB1
CCND1
CDC25C
CDK1
CDK2
CDK4
CDK7
CDKN2D
CEP57L1
CHEK1
CHEK2
CLSPN
CNRIP1
CNTLN
CNTN4
COL1A1
COMMD1
CREBBP
CRY2
CRYZL1
CSNK1D
CSNK2A1
CSNK2B
CSTF1
CTBP1
CTCFL
CTNNB1
CUBN
CWF19L2
DALRD3
DBF4
DCLRE1C
DCN
DDX24
DES
DHPS
DHX9
DNAJA1
DNAJA3
DNAJB1
DNHD1
DYNC1H1
DYNLT2B
E2F1
E2F4
EED
EIF3B
EIF4A2
EIF5B
ELK1
ELK4
ELOA
ENO1
EP300
ERCC5
ERCC6
ERO1B
ESR1
ETS1
ETV5
EZH2
FAM161A
FAM184A
FANCA
FANCD2
FBXO44
FHL2
FLI1
FLNA
FXR2
GCC1
GFI1B
GGN
GOLGA8DP
GTF3C4
GUSBP1
H2AC20
H2AC4
H2AX
HDAC1
HDAC2
HECTD3
HGF
HIBADH
HIVEP1
HNRNPC
HNRNPD
HORMAD1
HSPA14
HSPA8
HSPD1
IFI16
INPP1
ITIH5
ITPR1
ITPRID2
JAK1
JAK2
JUN
JUNB
JUND
JUP
KAT5
KDM1A
KIF1B
KPNA2
KPNA6
LCK
LCMT1
LDHC
LMNTD1
LMO4
LONRF1
MACROH2A1
MAN2C1
MAP3K1
MAP3K14
MAP3K3
MAP4K4
MARCKSL1
MDC1
MED1
MED21
MID2
MLH1
MNAT1
MSH2
MSH3
MSH6
MT-ND1
MYC
MYOZ1
NBN
NCOA2
NCOA3
NELFB
NFKB1
NFYA
NKAPL
NMI
NPC2
NRIP1
NUFIP1
NUP153
OBSCN
PARG
PEG3
PEX5
PGR
PHF12
PIAS1
PIAS4
PIK3R1
PILRB
PIN1
PISD
POLB
POLR2A
POLR2H
POLR2K
POM121
POMGNT1
POU2F1
PPHLN1
PPP1CA
PPP1CB
PPP1R13B
PPP2R5C
PREP
PRKAG3
PRKDC
PRMT1
PRPF3
PSAP
PSMA6
PSMA7
PSMD9
PSMG1
RACK1
RAD51
RANBP9
RB1
RBBP4
RBBP7
RBBP8
RBL1
RBL2
RCC1L
RELA
RFC1
RNF216
RPGRIP1
RPL31
RTKN2
RTL10
RUNX1T1
RWDD2B
RWDD4
SDK2
SETX
SKP2
SMAD2
SMAD3
SMAD4
SMARCA2
SMARCA4
SMC1A
SNRNP200
SNX3
SNX6
SOX30
SP1
SPATA4
SQSTM1
SSX2IP
STAC2
STAT1
STAT3
STAT5A
SUMO1
SYT6
TARS1
TATDN2
TCEA2
TCEANC
TEX101
THOC3
TLE4
TMPRSS12
TNS2
TOP1
TOP2A
TP53
TP53BP1
TPTE2
TRIM24
TRIM46
TRIM74
TRRAP
TSEN54
TSGA10IP
TUBA4A
TUBB
TUBG1
TULP2
TXLNA
UBB
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2E1
UBE2E2
UBE2E3
UBE2J1
UBE2K
UBE2L3
UBE2N
UBE2T
UBE2W
UBE3A
UBXN1
USF2
USH2A
USP2
VCP
WDR6
WNT2B
WRN
XIAP
XRCC1
XRCC5
YY1
ZNF280D
ZNF350
ZNF423
ZSCAN21
Entrez ID
5300
672
HPRD ID
03031
00218
Ensembl ID
ENSG00000127445
ENSG00000012048
Uniprot IDs
Q13526
A0A024R1V0
P38398
PDB IDs
1F8A
1I6C
1I8G
1I8H
1NMV
1NMW
1PIN
1ZCN
2F21
2ITK
2KBU
2KCF
2LB3
2M8I
2M8J
2M9E
2M9F
2M9I
2M9J
2N1O
2Q5A
2RUC
2RUD
2RUQ
2RUR
2XP3
2XP4
2XP5
2XP6
2XP7
2XP8
2XP9
2XPA
2XPB
2ZQS
2ZQT
2ZQU
2ZQV
2ZR4
2ZR5
2ZR6
3I6C
3IK8
3IKD
3IKG
3JYJ
3KAB
3KAC
3KAD
3KAF
3KAG
3KAH
3KAI
3KCE
3NTP
3ODK
3OOB
3TC5
3TCZ
3TDB
3WH0
4GWT
4GWV
4QIB
4TNS
4TYO
4U84
4U85
4U86
5B3W
5B3X
5B3Y
5B3Z
5BMY
5GPH
5UY9
5VTI
5VTJ
5VTK
6DUN
6O33
6O34
6SVC
6SVE
6SVH
1JM7
1JNX
1N5O
1OQA
1T15
1T29
1T2U
1T2V
1Y98
2ING
3COJ
3K0H
3K0K
3K15
3K16
3PXA
3PXB
3PXC
3PXD
3PXE
4IFI
4IGK
4JLU
4OFB
4U4A
4Y18
4Y2G
6G2I
Enriched GO Terms of Interacting Partners
?
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?