PI4KB and NCS1

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo, in vitro)

		PI4KB	NCS1
Description		phosphatidylinositol 4-kinase beta	neuronal calcium sensor 1
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GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Mitochondrial Outer Membrane Endosome Cytosol Membrane Rough Endoplasmic Reticulum Membrane Perinuclear Region Of Cytoplasm	Cytoplasm Golgi Apparatus Plasma Membrane Postsynaptic Density Dendrite Dense Core Granule Intracellular Membrane-bounded Organelle Calyx Of Held Perinuclear Region Of Cytoplasm Glutamatergic Synapse Presynaptic Cytosol Postsynaptic Cytosol
	Molecular Function	1-phosphatidylinositol 4-kinase Activity Protein Binding ATP Binding Phosphatidylinositol Kinase Activity 14-3-3 Protein Binding	Magnesium Ion Binding Voltage-gated Calcium Channel Activity Calcium Ion Binding Protein Binding Protein Kinase Binding Voltage-gated Calcium Channel Activity Involved In Regulation Of Presynaptic Cytosolic Calcium Levels
	Biological Process	Phosphatidylinositol Biosynthetic Process Receptor-mediated Endocytosis Signal Transduction Viral Process Phosphatidylinositol Phosphorylation Phosphatidylinositol-mediated Signaling	Regulation Of Neuron Projection Development Positive Regulation Of Exocytosis Phosphatidylinositol-mediated Signaling Calcium Ion Transmembrane Transport Regulation Of Presynaptic Cytosolic Calcium Ion Concentration Regulation Of Synaptic Vesicle Exocytosis
Pathways		Synthesis of PIPs at the Golgi membrane
Drugs		Fostamatinib	Calcium citrate Calcium Phosphate Calcium phosphate dihydrate
Diseases
GWAS		Body mass index ( 26426971) Gut microbiota (functional units) ( 27694959)	Alzheimer's disease (cognitive decline) ( 23535033) Tuberculosis ( 30713548)
Interacting Genes		4 interacting genes: NCS1 YWHAB YWHAG YWHAQ	27 interacting genes: C1QTNF2 CDSN CEP89 CREM CTAG1A CTAG1B DRD2 DRD3 DRD5 DTX2 FZD7 GRK2 IL1RAPL1 KCND2 LY6G6D MEOX2 MIEF2 NBL1 OXER1 PI4KB PRDM4 RNASEH1 SFTPA2 SIGLEC9 SPP1 SPRED2 ZC3H10
Entrez ID		5298	23413
HPRD ID		11805	04500
Ensembl ID		ENSG00000143393	ENSG00000107130
Uniprot IDs		A0A0B4J1S8 Q9UBF8	A0A024R8B2 P62166
PDB IDs		2N73 4D0L 4D0M 4WAE 4WAG 5C46 5C4G 5EUQ 5FBL 5FBQ 5FBR 5FBV 5FBW 5LX2 5NAS 6GL3	1G8I 2LCP 4GUK 5O9S 6QI4
Enriched GO Terms of Interacting Partners?
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