ATP6V1B1 and ACTN4

Data Source:
HPRD (in vivo)

		ATP6V1B1	ACTN4
Description		ATPase H+ transporting V1 subunit B1	actinin alpha 4
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Microvillus Basolateral Plasma Membrane Apical Plasma Membrane Lateral Plasma Membrane Vacuolar Proton-transporting V-type ATPase Complex Proton-transporting V-type ATPase, V1 Domain Extracellular Exosome Extrinsic Component Of Synaptic Vesicle Membrane	Stress Fiber Extracellular Region Extracellular Space Nucleus Cytoplasm Cytosol Focal Adhesion Actin Cytoskeleton Nuclear Body Platelet Alpha Granule Lumen Pseudopodium Protein-containing Complex Neuron Projection Perinuclear Region Of Cytoplasm Extracellular Exosome Ribonucleoprotein Complex
	Molecular Function	Protein Binding ATP Binding Proton Transmembrane Transporter Activity Hydrolase Activity Protein-containing Complex Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Nucleoside Binding Transcription Coactivator Activity RNA Binding Actin Binding Integrin Binding Calcium Ion Binding Protein Binding Nuclear Receptor Coactivator Activity Chromatin DNA Binding Nuclear Hormone Receptor Binding Protein Homodimerization Activity Retinoic Acid Receptor Binding Ion Channel Binding Protein N-terminus Binding Actin Filament Binding
	Biological Process	Ossification Renal Water Homeostasis Renal Sodium Ion Transport Prostaglandin Metabolic Process Regulation Of PH Excretion Sensory Perception Of Sound Insulin Receptor Signaling Pathway Regulation Of Gene Expression Regulation Of Macroautophagy Adult Behavior Transferrin Transport Ion Transmembrane Transport Renal Sodium Excretion Olfactory Behavior Inner Ear Morphogenesis PH Reduction ATP Metabolic Process Chloride Ion Homeostasis Calcium Ion Homeostasis Potassium Ion Homeostasis Phagosome Acidification Proton Transmembrane Transport	Response To Hypoxia Platelet Degranulation Protein Transport Vesicle Transport Along Actin Filament Positive Regulation Of Cell Migration Positive Regulation Of Sodium:proton Antiporter Activity Tumor Necrosis Factor-mediated Signaling Pathway Peroxisome Proliferator Activated Receptor Signaling Pathway Regulation Of Apoptotic Process Positive Regulation Of Transcription, DNA-templated Retinoic Acid Receptor Signaling Pathway Positive Regulation Of Cellular Component Movement Negative Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of NIK/NF-kappaB Signaling Regulation Of Nucleic Acid-templated Transcription
Pathways		ROS and RNS production in phagocytes Insulin receptor recycling Transferrin endocytosis and recycling Amino acids regulate mTORC1 Ion channel transport	Platelet degranulation Nephrin family interactions
Drugs		Tiludronic acid
Diseases		Distal renal tubular acidosis (RTA type 1)	Nephrotic syndrome and focal segmental glomerulosclerosis
GWAS		Acne (severe) ( 24927181) Urate levels ( 31578528)	Brain morphology (MOSTest) ( 32665545) Heart rate ( 23583979) Immature fraction of reticulocytes ( 32888494) Logical memory (immediate recall) in mild cognitive impairment ( 29274321) Mean platelet volume ( 32888494) Retinal venular tortuosity ( 31597446) Waist circumference ( 28552196)
Interacting Genes		5 interacting genes: ACTN4 KDM1A SLC9A3R1 STX1A SUV39H1	55 interacting genes: ACTC1 ACTN3 ADORA2A ATP6V1B1 ATXN7 BMP7 C14orf119 CAMK2A CAMK2B CAMK2G CDKN2A COIL COL17A1 DDIAS ESR1 GSN HDAC7 HSPB1 INO80 ITGB1 KPNA2 LCMT2 LNX1 LRRC7 MAGI1 MAPK7 MEF2A MEOX2 MICALL2 MYOZ1 MYOZ2 NEB NOS2 NOS3 PDLIM1 POT1 PTGER4 PTPN11 PTPN6 RARA RPS27 SACS SERPINE1 SLC2A4 SLC9A3R2 SORBS2 STAT1 TJP1 TRIM23 TRIM3 TTN TXN UCHL5 USP6NL VDR
Entrez ID		525	81
HPRD ID		01887	05222
Ensembl ID		ENSG00000116039	ENSG00000130402
Uniprot IDs		P15313	A0A0S2Z3G9 O43707
PDB IDs			1WLX 1YDI 2R0O 6O31 6OA6
Enriched GO Terms of Interacting Partners?
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