PFKL and ATN1

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		PFKL	ATN1
Description		phosphofructokinase, liver type	atrophin 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytosol 6-phosphofructokinase Complex Membrane Secretory Granule Lumen Extracellular Exosome Ficolin-1-rich Granule Lumen	Nucleus Nucleoplasm Cytoplasm Nuclear Matrix Cell Junction Perinuclear Region Of Cytoplasm
	Molecular Function	6-phosphofructokinase Activity Protein Binding ATP Binding AMP Binding Kinase Binding Identical Protein Binding Metal Ion Binding Monosaccharide Binding Fructose Binding Fructose-6-phosphate Binding	RNA Polymerase II Transcription Factor Binding Transcription Corepressor Activity Protein Binding Protein Domain Specific Binding
	Biological Process	Fructose 6-phosphate Metabolic Process Glycolytic Process Response To Glucose Fructose 1,6-bisphosphate Metabolic Process Neutrophil Degranulation Negative Regulation Of Insulin Secretion Canonical Glycolysis	Negative Regulation Of Transcription By RNA Polymerase II Central Nervous System Development Neuron Apoptotic Process
Pathways		Neutrophil degranulation Glycolysis	Regulation of PTEN gene transcription
Drugs
Diseases			Dentatorubropallidoluysian atrophy (DRPLA)
GWAS		Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) Rheumatoid arthritis ( 21505073)	Refractive error ( 32231278)
Interacting Genes		14 interacting genes: APP ATN1 COPS6 GTPBP3 KRTAP10-7 KRTAP4-12 KRTAP5-9 MYD88 PFKM PRPF40A SUMO2 TESK1 TNFAIP3 YWHAQ	121 interacting genes: AGRN ALG13 ARF3 ATRX BAG3 BAG6 BAIAP2 CACNB1 CASP1 CASP3 CBFA2T2 CENPJ CHRD CRACR2A CRIP2 CSNK2A1 CTNND2 DGCR6L DMPK DMRT3 DVL1 DVL2 ECM1 EFEMP1 EFEMP2 ETNK2 EWSR1 FBLN1 FBLN2 FBLN5 GAPDH GCC1 GIGYF1 GRN HGS HINFP HNRNPF HSPG2 ITCH JAG2 KAT6A KAT6B KAT7 KRT31 KRTAP12-2 KRTAP15-1 KRTAP19-2 KRTAP19-5 KRTAP4-12 KRTAP6-2 KRTAP9-3 LENG8 LRP2 LTBP1 LTBP4 LYST MAGI1 MAGI2 MAP7D1 MBP MDFI MEGF11 MEGF6 MEGF8 NCK2 NELL1 NELL2 NOC2L NR2E1 OLIG3 P4HA3 PCSK5 PDCD6IP PFKL PIN1 PITX1 PITX2 PLSCR1 PPP1R32 PRRC2A PRRC2B PSMA3 PSME3 RAD54L2 RBFOX1 RBFOX2 RBM10 RBM14 RBM4B RBPMS RCHY1 RERE RHOXF2 RNF115 RNF31 RUNX1T1 SH3RF1 SIAH1 SIAH2 SLC25A48 SLIT1 SPAG5 SS18L1 SSPOP STXBP4 SYVN1 TEKT3 TEP1 TLE1 TLE5 TNFAIP8 TRIP6 USP2 USP54 VIM WDR5 WWP1 WWP2 ZMYND8 ZNF503 ZSWIM8
Entrez ID		5211	1822
HPRD ID		01385	06311
Ensembl ID		ENSG00000141959	ENSG00000111676
Uniprot IDs		P17858 Q7L2M7	P54259 Q86V38
PDB IDs
Enriched GO Terms of Interacting Partners?
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