PFKL and PFKM

Data Source:
HPRD (in vitro)

		PFKL	PFKM
Description		phosphofructokinase, liver type	phosphofructokinase, muscle
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytosol 6-phosphofructokinase Complex Membrane Secretory Granule Lumen Extracellular Exosome Ficolin-1-rich Granule Lumen	Nucleus Cytosol 6-phosphofructokinase Complex Membrane Apical Plasma Membrane
	Molecular Function	6-phosphofructokinase Activity Protein Binding ATP Binding AMP Binding Kinase Binding Identical Protein Binding Metal Ion Binding Monosaccharide Binding Fructose Binding Fructose-6-phosphate Binding	6-phosphofructokinase Activity Protein Binding ATP Binding Protein C-terminus Binding AMP Binding Kinase Binding Identical Protein Binding Metal Ion Binding Monosaccharide Binding Fructose Binding Fructose-6-phosphate Binding
	Biological Process	Fructose 6-phosphate Metabolic Process Glycolytic Process Response To Glucose Fructose 1,6-bisphosphate Metabolic Process Neutrophil Degranulation Negative Regulation Of Insulin Secretion Canonical Glycolysis	Fructose 6-phosphate Metabolic Process Glycolytic Process Fructose 1,6-bisphosphate Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Muscle Cell Cellular Homeostasis Glycolytic Process Through Fructose-6-phosphate Canonical Glycolysis
Pathways		Neutrophil degranulation Glycolysis	Glycolysis
Drugs
Diseases			Glycogen storage diseases (GSD), including: von Gierke disease (GSD type Ia); Pompe disease (GSD type II); Cori disease, Forbe disease (GSD type III); Andersen disease (GSD type IV); McArdle disease (GSD type V); Hers disease (GSD type VI); Tarui disease (GSD type VII); Phosphorylase kinase deficiency (GSD type IX); Fanconi-Bickel syndrome (GSD type XI); Glycogen synthase deficiency (GSD type 0)
GWAS		Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) Rheumatoid arthritis ( 21505073)	Hematocrit ( 32888494 27863252) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) High light scatter reticulocyte count ( 32888494) Immature fraction of reticulocytes ( 32888494) Longevity (90 years and older) ( 25199915) Mean corpuscular hemoglobin concentration ( 32888494) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483) Pulse pressure ( 30578418) Red blood cell count ( 32888494)
Interacting Genes		14 interacting genes: APP ATN1 COPS6 GTPBP3 KRTAP10-7 KRTAP4-12 KRTAP5-9 MYD88 PFKM PRPF40A SUMO2 TESK1 TNFAIP3 YWHAQ	19 interacting genes: ATP6V0A4 CAV3 DLC1 DYNLL1 FHL2 HGS LSM7 MAPK3 NDUFB2 NOS1 PCNA PDGFRL PFKL SFRP2 SFRP4 SIAH1 SUMO2 TEAD4 UBTD1
Entrez ID		5211	5213
HPRD ID		01385	01988
Ensembl ID		ENSG00000141959	ENSG00000152556
Uniprot IDs		P17858 Q7L2M7	A0A024R0Y5 A0A2R8Y891 P08237
PDB IDs			4OMT
Enriched GO Terms of Interacting Partners?
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