PFDN5 and PRKAB2

Data Source:
BioGRID (two hybrid)

		PFDN5	PRKAB2
Description		prefoldin subunit 5	protein kinase AMP-activated non-catalytic subunit beta 2
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Prefoldin Complex Intermediate Filament Cytoskeleton	Nucleus Nucleoplasm Cytoplasm Cytosol Nucleotide-activated Protein Kinase Complex
	Molecular Function	Amyloid-beta Binding Transcription Corepressor Activity Protein Binding Unfolded Protein Binding	AMP-activated Protein Kinase Activity Protein Binding Protein Kinase Binding Identical Protein Binding
	Biological Process	Regulation Of Transcription, DNA-templated Protein Folding Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Amyloid Fibril Formation	Protein Phosphorylation Fatty Acid Biosynthetic Process Carnitine Shuttle Cell Cycle Arrest Signal Transduction Macroautophagy Regulation Of Macroautophagy Regulation Of Fatty Acid Biosynthetic Process Regulation Of Catalytic Activity Regulation Of Primary Metabolic Process Positive Regulation Of Cold-induced Thermogenesis Regulation Of Signal Transduction By P53 Class Mediator
Pathways		Prefoldin mediated transfer of substrate to CCT/TriC	Translocation of SLC2A4 (GLUT4) to the plasma membrane Macroautophagy AMPK inhibits chREBP transcriptional activation activity AMPK inhibits chREBP transcriptional activation activity Carnitine metabolism Activation of PPARGC1A (PGC-1alpha) by phosphorylation Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Regulation of TP53 Activity through Phosphorylation Lipophagy Activation of AMPK downstream of NMDARs
Drugs			Adenosine phosphate Acetylsalicylic acid Fostamatinib
Diseases
GWAS
Interacting Genes		114 interacting genes: ABI2 ANKRD55 BCAS2 BCL6 BHLHE40 BRMS1 C10orf55 C10orf62 C20orf85 C22orf39 C4orf45 C7orf31 CALCOCO2 CCDC198 CSPP1 DMRT3 DOK4 DOK5 ELK3 ESPNL FAAP20 FAM102A FAM110A FAM214B FAM221A FAM222B FAM90A1 GLRX3 GLYCTK GPANK1 GSTO2 GUCD1 HAPLN2 HHEX HOXB9 HOXC8 IKBKG IKZF3 IL16 INCA1 IRX2 IRX6 ITSN1 KCTD9 KDM1A KLHL38 KLHL42 LARP4 LNX1 MAP2K5 METTL21A MISP MRPL45 MYC MYOT MYOZ1 NEUROG2 NOXA1 NTAQ1 PATZ1 PAX9 PFDN2 PFDN6 PHF1 PHF24 PILRA PITX1 PITX2 POGZ PPP1R32 PRKAB2 PRPF18 PRR35 PSMB4 PSMB8 PSME3 RIBC1 RIPPLY1 RSRC2 RUSC1 SAXO1 SCNM1 SDCBP SHISA6 SLAIN1 SMAP1 SMG9 SNAI1 SNRNP25 SNRPB SOHLH1 SPAG8 SPG21 STK19 SYCE1L SYT17 TAF6L TBX3 TCF19 TFG TLE5 TP73 TRAPPC6A TRIM28 TUBA1B TUBA3C VAX2 VBP1 VEZF1 VGLL1 WDR25 YPEL5 ZC2HC1C ZNF148	170 interacting genes: ABHD11 ADAMTSL4 ANAPC11 ARID5A AUNIP AVP BANP BEND5 BHLHB9 BLZF1 C11orf1 C19orf54 C2orf42 C3orf36 CALCOCO2 CASP2 CASP6 CCDC28B CCDC33 CDC14B CDSN CDX4 CFP CREB3L1 CRX CSNK2B CYSRT1 DAO DDAH2 DDIT4L DICER1 DOK3 DST ELL2 EPM2A ESM1 FDX1 FLNC GATA1 GATAD2B GCSAML GET4 GOLGA2 GOLGA6L9 GORASP2 GRAPL GRN GSC2 IHO1 IKZF1 IKZF3 IL37 IRAK1BP1 KATNBL1 KCTD5 KHDC4 KLF15 KRBOX4 KRT31 KRT40 KRTAP1-1 KRTAP1-3 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP17-1 KRTAP2-3 KRTAP2-4 KRTAP3-3 KRTAP4-12 KRTAP4-2 KRTAP4-5 KRTAP5-9 KRTAP9-2 KRTAP9-3 KRTAP9-4 KRTAP9-8 LHX3 LRIF1 LZTS1 LZTS2 MAGED1 MAJIN MDFI MEOX2 METTL27 MORN3 NAB2 NEBL NHLRC4 NUTM1 OXER1 PDE6G PDE6H PFDN5 PIAS2 PNMA1 PPP1R13B PPP1R16A PRDM14 PRKAA1 PRKAG1 PRKAG2 PSMD11 PSME3 PYGM QKI RAB3IP RACK1 RBM48 RBPMS REL RHEBL1 RIMBP3 RNF144B ROR2 RPH3AL SAMD4A SERTAD2 SMARCB1 SMUG1 SPRY1 SPRY2 SSC4D SSX2IP STX11 STX19 TADA2A TASOR2 TCF12 TCF19 TCF4 TCF7L2 TGM7 TLE5 TNNI1 TP53 TP53BP2 TRAF1 TRAF2 TRIB3 TRIM10 TRIM14 TRIM35 TRIM42 TRIM54 TRIM55 TRIM63 TSR2 TTC23 UBXN11 USP54 VBP1 VPS28 WDR83 YPEL3 YY1AP1 ZBTB32 ZC2HC1C ZFP90 ZMYND19 ZNF177 ZNF236 ZNF474 ZNF526 ZNF559-ZNF177 ZNF581
Entrez ID		5204	5565
HPRD ID		05359	04117
Ensembl ID		ENSG00000123349	ENSG00000131791
Uniprot IDs		Q99471	O43741
PDB IDs		6NR8 6NR9 6NRB 6NRC 6NRD	2F15 2V8Q 2V92 2V9J 2Y8L 2Y8Q 2YA3 4CFH 4EAI 4EAJ 4RER 4REW 6B2E
Enriched GO Terms of Interacting Partners?
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