CFB and LAMC3

Data Source:
BioGRID (two hybrid)

		CFB	LAMC3
Description		complement factor B	laminin subunit gamma 3
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Extracellular Exosome Blood Microparticle	Extracellular Region Basement Membrane Membrane Extracellular Matrix
	Molecular Function	Complement Binding Serine-type Endopeptidase Activity Protein Binding	Structural Molecule Activity
	Biological Process	Proteolysis Complement Activation Complement Activation, Alternative Pathway Regulation Of Complement Activation	Visual Perception Animal Organ Morphogenesis Tissue Development Astrocyte Development Cell Migration Extracellular Matrix Organization Substrate Adhesion-dependent Cell Spreading Retina Development In Camera-type Eye
Pathways		Alternative complement activation Activation of C3 and C5 Regulation of Complement cascade	Laminin interactions Laminin interactions Non-integrin membrane-ECM interactions MET activates PTK2 signaling
Drugs		Zinc 4-guanidinobenzoic acid Diisopropylphosphono Group MLN2222 Zinc acetate
Diseases		Alternative complement pathway component defects, including the following four diseases: Factor B deficiency; Factor D deficiency; Factor H deficiency; Properdin deficiency
GWAS		Advanced age-related macular degeneration ( 26691988) Age-related macular degeneration ( 20385819 20385826 22694956 23577725 23455636 21665990) Age-related macular degeneration (choroidal neovascularisation) ( 22705344) Age-related macular degeneration (extreme sampling) ( 23577725) Age-related macular degeneration (geographic atrophy) ( 22705344) Asthma ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 29875488 28240269) Chronic hepatitis B infection ( 25802187) Coronary artery disease ( 29212778) Disease progression in age-related macular degeneration ( 29346644) Height ( 28552196) Hematology traits ( 23263863) Inflammatory bowel disease ( 28067908) Neutrophil percentage of white cells ( 32888494) Prostate cancer ( 23535732) Rosacea symptom severity ( 29771307) Type 1 diabetes and autoimmune thyroid diseases ( 25936594) Ulcerative colitis ( 24837172 28067908)	Alcohol consumption (max-drinks) ( 29460428) Deep ovarian and/or rectovaginal disease with dense adhesions ( 28333195) Degraded stimulus continuous performance test score ( 31596458) Endometriosis ( 28333195) Oral cavity and pharyngeal cancer ( 27749845) Oral cavity cancer ( 27749845) Smoking status (heavy vs never) ( 26423011)
Interacting Genes		5 interacting genes: C3 CFP LAMC3 LAMTOR5 RPA2	20 interacting genes: ANXA5 CFB CRP CSNK2A2 CWC25 CYP2E1 EPB41L4B FRAT1 HP KIF1C LGMN NR1H2 PELI2 POT1 RPL35 SERPINA3 SLC43A3 TF YTHDC1 ZNF160
Entrez ID		629	10319
HPRD ID		00718	05069
Ensembl ID		ENSG00000243649	ENSG00000050555
Uniprot IDs		A0A1U9X7H8 P00751	Q8N2D6 Q9Y6N6
PDB IDs		1DLE 1Q0P 1RRK 1RS0 1RTK 2OK5 2WIN 2XWB 2XWJ 3HRZ 3HS0 6QSW 6QSX 6RAV 6RUR 6RUV 6T8U 6T8V 6T8W
Enriched GO Terms of Interacting Partners?
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